“a borderline significant trend”

Intriguingly, the GEO cohort showed a borderline significant trend toward higher FOXP3/IL-17A ratios in MYC-high patients, potentially indicating a biologically relevant trend of MYC expression and Treg/Th17 balance, consistent with our primary findings.

While TFF and TFD yielded statistically significant pooled effects, LOS showed a borderline significant trend in the same direction.

A borderline significant trend was set at p < 0.1. 4.7.

For the TCGA-LUAD and TCGA-LUSC cohorts, LUAD patients with the B27 supertype had significantly poorer OS than those without B27 (log-rank, P = 0.049, Figure S5A-B), and LUSC patients with the A24 supertype showed a borderline significant trend of longer OS than those without A24 (log-rank, P = 0.08, Figure S5C-D).

Additionally, a borderline significant trend indicated an increased number of DED symptoms in the BAK ‐preserved AT group compared to preservative‐free AT users.

While cumulative glucocorticoid dose was not consistently associated with cataract risk, higher cumulative exposure showed a borderline significant trend toward increased risk (adjusted OR=1.14, 95% CI 0.99 to 1.31).

For OS, the pooled HR was 0.88 (95% CI: 0.78–1.00, p = 0.06), reflecting a borderline significant trend favoring ADCs, with negligible heterogeneity ( I 2 = 0%).

There was a borderline significant trend towards a higher proportion of patients receiving oral corticosteroid therapy in the COVID-19 group compared to the negative group—35 vs. 30 patients (χ 2 = 3.2, p = 0.051).

Patients with low-proliferative C2 tumors, as determined by SSP-Ki67, showed a borderline significant trend toward improved prognosis in univariable analysis (SSP-Ki67: HR = 0.104, 95 % CI: 0.011–1.006, Log-rank p = 0.017; Fig. 5 ).

The multiple regression analysis showed a borderline significant trend, indicating that blood PCDD/Fs concentrations increased with longer residence periods in the exposure area.

In multivariable analysis, absence of DCIS and low PR expression remained independently associated with lower odds of SLNB positivity, whereas low Ki-67 showed a borderline significant trend towards higher odds of nodal metastasis.

Calcium intake showed a borderline significant trend (p-trend = 0.05).

In contrast, the minimal adherence cluster of 10 participants showed a borderline significant trend toward improved 6-MWD, contrary to our expectations.

For psychosocial health, a borderline significant trend suggesting a greater improvement in health literacy (Communicative and Critical Health Literacy [CCHL]) was noted in the intervention group (β = 0.13, 95% CI: 0.00, 0.26; p = 0.056).

Although the significance of discordant cancers is controversial, patients with discordant cases demonstrate a borderline significant trend toward survival differences compared to those with concordant cases, which may be a potential therapeutic strategy for discrepant tonsil cancers with SMARCB1 mutation [ 47 , 48 , 49 ].