“a numerical trend”

In female patients assigned to mGPS category 1 or 2, a numerical trend towards longer OS was also observed in Arm A compared to Arm B, however, with statistical testing not revealing a significant survival difference between treatment arms (24.6 versus 16.7 months; P = 0.15) ( Supplementary Table S1 , available at https://doi.org/10.1016/j.esmoop.2024.103374 , Figure 4 A and B).

This long-term, prospective, randomised, head-to-head trial demonstrated a numerical trend for increased risk of MACE and VTE (only the 10 mg dose), among other serious adverse events, for the JAK inhibitor tofacitinib compared with TNF inhibitor therapy in a population enriched for CV risk (patients who were aged ≥50 years with at least one CV risk factor). 16 The increased relative ris

15 Final OS results show a numerical trend favoring ipatasertib–paclitaxel (median OS 23.1 vs 18.4 months in ipatasertib vs placebo arm, stratified HR 0.62 [95% CI, 0.37-1.05]). 33 However, the Phase III IPATunity130 cohort A failed to show PFS benefit from the addition of ipatasertib to paclitaxel in patients with mTNBC harboring PIK3CA/AK

Nonetheless, those patients who had ≥12 months of PFS during prior palbociclib‐based therapy only had a numerical trend towards PFS improvement compared with those patients who had less than 12 months of PFS during prior palbociclib‐based therapy (median PFS: 7.0 vs. 5.0 months, log‐rank p = 0.931).

Furthermore, a numerical trend toward higher chronic kidney disease in the urgent group was evident.

A numerical trend favoring birtamimab in the primary composite end point for the overall population was observed and was hypothesized to be driven by a treatment effect in the most advanced patients (Mayo stage IV).

While a numerical trend in favoring prolonged ET for patients with a higher CTS5 was found, a significantly predictive value for the score could not be confirmed.

In other words, these simulations would have showed at the interim data cut that it is unlikely that the final OS dataset would show a numerical trend in the hazard ratio favoring the combination therapy over the chemotherapy alone.

While they did not observe a statistically significant reduction in OS by Kaplan-Meier analysis, there was a numerical trend towards reduced survival in patients whose tumours demonstrated ZNF331 methylation.

While more patients experienced dostarlimab-related AEs (71%) than pembrolizumab-related AEs (57%), a numerical trend favoring dostarlimab was observed in the proportion of patients experiencing immune-related adverse events (irAEs) (31% for dostarlimab plus chemotherapy and 39% for pembrolizumab plus chemotherapy), serious adverse events (SAEs) (41% and 48%, respectively), AEs leading to treatment discontinuation (29% and 38%, respectively), and AEs leading to immunotherapy discontinuation (17% and 24%, respectively) (Table 5 ).

Moreover, a numerical trend of better PFS outcomes among bone-only progressors compared to others, in our cohort, underlines the potential benefit of timely diagnosis (avoiding the potential risks and comorbidities associated with a late diagnosis) and early treatment intervention.

In women, ever smokers and smoking amount showed a numerical trend towards lower risk of death and hospitalisation, but were only significantly associated with respiratory hospitalisation (Additional file 1: Table S2 and Table S3 ).

Unlike prior studies of untreated psychosis, 32 we did not see a higher neuromelanin-MRI signal in those with FES compared to healthy controls, but noted a numerical trend in the relevant voxels (eFigure 2 in Supplement 1 ). 27 Alongside the lack of power, it is possible that the limited effect of FES on neuromelanin-MRI signal is due to treatment effect.

There is a numerical trend indicating that flumazenil-associated encounters required more interventions to improve ECT effects compared with nonflumazenil encounters, including lead placement change and caffeine provision.

LAAC was associated with a numerical trend towards lower risk of hemorrhagic stroke when compared with DOACs (OR, 0.45 [95% CI, 0.17–1.22]) with no evidence of inconsistency between direct and indirect treatment comparisons ( P =0.927).

Despite a numerical trend, statistical significance was not confirmed for Lp(a) levels in relation to MADS2-CVD or MADS2-PVD scores.

Besides the bias towards a lower real-time CO, real-time measurements showed a numerical trend towards a better agreement with the reference standard compared to the other CMR techniques.

While certain complications (VTE, subclavian hematoma) showed a numerical trend toward higher incidence in females, none reached statistical significance, likely due to limited sample size.

Interestingly, despite the small treated cohort, a numerical trend toward a higher digoxin serum concentration and stronger reduction in the average cluster size at day 7 was observed (secondary endpoint) (linear regression coefficient −4.65, P = 0.14; Fig. 1g ), suggesting that higher digoxin serum levels or more potent Na + /K + ATPase inhibitors could be more effective in cluster dissolution.

Based upon our observation of a numerical trend, we conducted a series of exploratory partial correlations between fixation durations and mean performance during each of the five IGT blocks controlling for group.

No significant difference was observed in the OS analysis between the shedding and non-shedding groups, though a numerical trend favoring non-shedders was noted.

However, there was a numerical trend towards a higher ORR in the ATM mutant group compared to the ATM wild-type group [ 16 ].

Although a numerical trend favoring barbed sutures over conventional sutures was noted with low heterogeneity, the difference was not statistically significant.

Although no statistically significant difference was observed among the three groups, the weight-based TXA group exhibited a numerical trend toward a longer tourniquet application time compared with the other two groups.

Although not statistically significant, there was a numerical trend suggesting higher overall survival (OSI) in patients with eosinophilia (42.6 months [95% CI, 26.3–58.8]) compared to those without eosinophilia (27.9 months [95% CI, 19.8–36.1]), with a two‐sided p ‐value of 0.178.