“a significant trend”

A significant trend indicated a lower OS as the N status increased (for N0: 42 [95% CI 34–50) months; N1: 32 [95% CI 28–36] months; N2: 24 [95% CI 14–35] months; p = 0.008).

Figure 1 and Figure 2 depicted a significant trend association between the case numbers and the seasonal and monthly temperatures ( p = 0.008 and p = 0.005). 3.5.

There was a significant trend of increasing risk of hypertension in corresponding to increasing level of urinary MMA concentration ( p = 0.009).

A significant trend towards increased risk was observed in the potentially less protective genotype GSTM1 / CYP1A1 ( p < 0.009, (Χ 2 trend test).

There was a significant trend for higher prevalence of central obesity among those in the lower occupation groups (p = 0.009).

The subgroup analysis by analgesic type in our meta-analysis revealed a significant trend toward reduced PCA use with ESPB compared to morphine (MD: -8.78, 95%CI: -15.34 to -2.22, P = 0.009).

Similarly, a significant trend towards better outcomes was observed with increasing Kawaguchi scores ( p = 0.009), with grade 1 tumors having a 51.7% lower probability of good outcomes compared to grade 3 ( Figure 4 and Figure 5 ).

Fewer alterations were found in patients with metaplasia alone and there was a significant trend towards a higher frequency of alterations with increasing histologic grade (p = 0.009).

When analyzed by quartiles, a significant trend emerged (OR: 0.85 per quartile increase, 95% CI: 0.75-0.96, P=0.009).

However, there was a significant trend towards greater risk of problem drinking among those experiencing varying changes, from a decrease to a rise, in inequality ( p = 0.009).

In addition, meta-regression of serum gastrin elevation ( Figure 4(e) and ( f )) revealed a significant positive correlation with both treatment duration and vonoprazan dosage, where longer therapy was associated with greater gastrin elevation compared with lansoprazole (coefficient = 1.7972 per week, p < 0.0001) and higher vonoprazan doses showed a significant trend toward increased gastrin levels (coefficient = 9.3422 per mg, p = 0.0093).

[ 63 ], conducted a case-control study in the USA and found a significant trend for increased breast cancer risk in post-menopausal women exposed to high PAH levels at birth ( P = 0.01), with ORs ranging from 1.94 to 2.42, suggesting a dose-response relationship.

It is worth noting that the Pielou evenness index showed a significant trend of first decreasing and then increasing with increasing longitude ( p < 0.01) (Figure 3c ).

In this study, the prominent impact of the COMT in patients with schizophrenia was found in the frontopolar PFC, whereas there was also a significant trend (uncorrected p<0.01) in the dorsolateral and ventrolateral PFC.

From the pooled data we derive that the overall force/CSA is higher among the C57BL/10 mice compared to mdx (ANOVA, p < 0.01) independent of temperature, and there is a significant trend toward increasing force with increasing temperature (ANOVA, p < 0.01) for the overall data set.

OxLDL significantly reduced MMP integrity, while NAC treatment restored mitochondrial polarization showing a significant trend with increasing doses ( p < 0.01).

There was a significant trend (Armitage trend test p < 0.01) of decreasing IFI incidence with increasing GA, falling from 4.6% at 22–23 weeks GA to 0.2% at 28 weeks GA ( Figure 3 ).

In terms of lung cancer, sensitivity analysis using adjusted estimates only showed a significant trend towards a higher incidence of lung cancer among HF patients [HR, 1.68 (95% CI: 1.13–2.49), P = 0.01] (see Supplementary material online , Figure S9 ).

Plasma NGAL levels also increased progressively with AKI stage: 481.6 ng/mL (stage 1), 625.5 ng/mL (stage 2), and 760.2 ng/mL (stage 3), showing a significant trend ( P < 0.01).

Hospital-based primary care providers had the highest proportion of participants who felt care had improved (80.9%), whereas two-thirds of COPC participants (67.1%) and half (50.0%) of Consortium participants did so, representing a significant trend (Spearman’s rho, p ≤ 0.01).

The results showed a significant trend (χ 2 = 10.101, p = 0.01) (Gamma = 0.125, p = 0.001) between the two groups in the 2005BDR + group, indicating a weak positive correlation.

Compared to controls, S-losers had significantly lower plasma anti-HBc levels prior to HBsAg seroclearance, with a significant trend of declining plasma anti-HBc 8–5 years prior to HBsAg seroclearance (p < 0.01), while such trend was not observed in controls.

In the treatment-group, there was a significant trend of lower levels of proinflammatory cytokine interleukin (IL)-2 during 6-hour adsorption compared to the control group ( P = .01).

If a significant trend was detected at p ≤ 0.01, Williams’ test was used [ 21 ]; if the trend was not significant Dunnett’s test was used [ 22 ].

However, a significant trend of higher LN count and higher likelihood of liver metastases was observed ( P = 0.010).