Barely Significant
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borderline significance

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borderline significancep = 0.0561.1× alpha
falciparum malaria, nor over the course of follow-up except for borderline significance with capillary higher than venous specimens by 21% on day 1 ( p = 0.056), when aggregating all demographic groups (Fig. 2 ; Additional file 1 : Table S1).
The DD genotype alone, reaching borderline significance in the univariate analysis (42% in cases vs 31% in controls; p = 0.056) remained significant also after adjustment for conventional risk factors (p = 0.005) with a independent role on predicting events (OR 2.39 CI 1.25–4.58, p = 0.008); whereas the CYP11B2 polymorphism (CC genotype, 27% vs 17%, p = 0.054) reached borderline significance only in the crude analysis, but lost an independent role after adjustment for confounders.
borderline significanceP = .0561.1× alpha
Analyzing HRs for each AAC grade, AAC grade 1 had a borderline significance ( P = .056) for predicting MACE compared to grade 0, suggesting that even trivial calcium deposition in aortic arch implies increased CV risk for ACS patients undergoing PCI.
borderline significanceP =0.0561.1× alpha
When the analysis was performed according to the menopausal status, this association was maintained with a borderline significance in premenopausal patients (140 vs 122 days, P =0.056), whereas it was completely lost in postmenopausal patients (191 vs 181 days, P =0.45).
borderline significanceP = 0.0561.1× alpha
Nevertheless, the borderline significance of the adjusted malignancy risk (P = 0.056) suggested an emerging safety signal that would become more apparent during longer follow-up periods. 3.5 Secondary outcomes (2–6 years) Among 5,505 patients followed beyond 1 year (4,250 fast-exposure and 1,255 slow-exposure phenotypes), significant differences emerged in safety outcomes, while efficacy remained comparable ( Table 5 ).