“did not reach statistical significance”

For menstrual pain duration, the intervention group showed a trend toward fewer pain days compared with the control group; however, this difference did not reach statistical significance in adjusted analyses.

In Ad.GFP-infected cells, the mitochondrial fission protein Drp1 showed a trend toward reduced levels; however, this change did not reach statistical significance.

Fecal moisture content showed an increasing trend in the JCJ-HYD, NF-HYD, FNF-HYD, and FNF/2-HYD groups; however, these changes did not reach statistical significance ( Figure 4 H).

In contrast, the Shannon diversity index exhibited a decreasing trend in the F group, although this change did not reach statistical significance ( p > 0.05).

Western blot analysis showed that although the phosphorylation of AMPK (p-AMPK) exhibited an increasing trend in the MG5012- and MG741-treated groups compared to the HFD group, this difference did not reach statistical significance ( Figure 4 F,I).

Cerebral malperfusion also showed a trend toward a higher prevalence in the non-elderly group, although this difference did not reach statistical significance (6.6% vs. 2.3%, p = 0.06).

Furthermore, a correlation analysis indicated a positive trend between fecal acetate and butyrate levels (r = 0.3562), although this did not reach statistical significance ( P = 0.0805, Figure 8D ). 4 Discussion OIPN remains a critical dose-limiting side effect in diverse chemotherapy regimens, with currently limited therapeutic options ( 6 ).

In primary hepatocytes, HMOX1 expression was significantly elevated in the WD group ( p < 0.05), while DNAJB1 and GADD45B showed a trend toward upregulation that did not reach statistical significance (Fig. 3 a–c).

In TCGA-HNSC, CIBERSORTx-based deconvolution suggested that higher C6-like signature scores were significantly associated with worse survival, whereas higher C9-like scores showed a trend toward better survival but did not reach statistical significance (Fig. 2 h).

However, knowledge regarding the role of HCPs in addressing GBV, while showing a positive trend, did not reach statistical significance.

In contrast, participants who had lost a parent (i.e., child bereaved individuals) showed a trend toward increased odds of being in LC3 compared to LC1 (OR=3.77, 95% CI=0.66–21.61), although this effect did not reach statistical significance (p=0.136).

Female sex showed a trend toward a lower relapse risk but did not reach statistical significance (HR: 0.63, 95% CI: 0.16–2.52, P = 0.071).

A history of hypertension showed a trend toward a negative association that approached, but did not reach statistical significance (adjusted OR = 0.424, 95% CI: 0.178–1.009; p = 0.052).

QoL outcomes showed a positive trend favoring TCM combination therapy (SMD: 0.82, 95% CI: -0.17 to 1.81), although this did not reach statistical significance.

Β cell mass showed an increasing trend with LNP-induced PD-L1 expression, but did not reach statistical significance ( Figures 4 G and 4H): however, eGLP-LNP+ CD274 -treated islets displayed a decrease in severe insulitis compared to PBS, empty LNP, and unconjugated LNP+ CD274 conditions ( Figure 4 I).

Gender showed a trend toward lower odds of failure among males compared to females (OR 0.65, 95% CI: 0.4–1.2), although this did not reach statistical significance ( P = 0.068).

While the primary analysis for superiority showed a trend toward benefit, it did not reach statistical significance.

AS01 B also showed a trend toward greater reactogenicity, though this difference did not reach statistical significance.

Days since hospitalization showed a positive trend but did not reach statistical significance at this stage ( p = 0.081) ( Supplementary Table S4 ).

In the mechanical nociception assay, 18-AG supplementation showed a trend toward the restoration of nociceptive responses to von Frey filament (20.1 mN) in AGPS KO larvae, although this did not reach statistical significance ( p = 0.095 vs.

In our cohort, this score showed a numerical trend toward survival stratification; however, differences in OS and disease control rate (DCR) did not reach statistical significance.

For food-related stimuli, the Group × Time interaction for LPP amplitude did not reach statistical significance but showed a trend in the same direction.

However, as shown in Figure 8 , although an increasing trend in the fibrosis index was observed in ECE-positive cases, these differences did not reach statistical significance.

DP treatment significantly restored the expression of claudin-1 and ZO-1 in FC-treated IPEC-J2 cells, whereas occludin showed an increasing trend that did not reach statistical significance ( Figure 4 A).

Compared with MTAP wild-type tumors (median 63 years, IQR 55–69), patients with MTAP deletion showed a trend toward older age; however, this difference did not reach statistical significance (Wilcoxon rank-sum test, p = 0.069).