Barely Significant
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did not reach statistical significance

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In the literature

interaction term between study year and education; other tested combinations did not reach statistical significance at p < 0.05) Model 1, the effects were slightly attenuated, but retained their significance with substantial variance in SSB consumption by study year, sex, age, and education.
did not reach statistical significanceP > 0.051.0× alphaplainly factual
showed a trendP > 0.051.0× alpha
Regarding fibrosis indicators, although PCSK9i use showed a trend toward improvement in Δ APRI (β = −0.021) and Δ FIB-4 (β = −0.19), these associations did not reach statistical significance in the adjusted model ( P > 0.05).
Among the 52 patients in each group matched for age, ECOG PS, and treatment response to R‐MVP, median PFS was not reached in the ASCT group and was 90.0 months (95% CI 41.0–NR) in the WBRT one, but the difference did not reach statistical significance ( p = 0.050, Figure 2A ).
did not reach statistical significancep > 0.051.0× alphaplainly factual
showed a trendp > 0.051.0× alpha
Although inflammatory markers such as tumor necrosis factor-alpha (TNF- α ), interleukin-6 (IL-6), and C-reactive protein (CRP) showed a trend toward elevation in SAE patients, these differences did not reach statistical significance ( p > 0.05, Supplementary Table S2 ).
Later age of symptom onset (70+ years) was associated with lower odds of genetic testing completion (OR 0.23; 95% CI 0.12–0.43; P < 0.001) compared to the reference group (10–19 years), while early symptom onset (0–9 years) showed a trend toward higher odds of genetic testing completion that approached but did not reach statistical significance (OR 1.53; 95% CI 1–2.37; P = 0.05).
At the protein level, BDNF exhibited a trend of upregulation consistent with mRNA changes but did not reach statistical significance. p-TrkB protein levels were reduced in CRS mice ( p < 0.05 vs. control), and BDT treatment significantly reversed this decrease ( p < 0.01 vs.
In addition, epidermal consumption (p = 0.07) and increased mitotic activity (p = 0.05) were more frequent in cases with homozygous 9p21 deletion, but these differences did not reach statistical significance. When the clinical features were considered, there was a statistically significant correlation between 9p21 FISH positivity and the diameter (p < 0.05).
Such skewing towards overestimating the presence of X4 minority variants for these CRFs was maintained when the FPR cut-off was shifted, although these observations did not reach statistical significance using a Fisher’s exact test (p<0.05).