However, upon further adjustment for lifetime smoking, the effect sizes of the association slightly attenuated and did not reach statistical significance after Bonferroni correction (OR: 0.986; 95% CI: 0.975–0.998; p = 0.020) (Fig. 4 ).
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This outcome, whose individual components did not reach statistical significance, occurred in 35.5% of patients on treatment vs. 38.5% in the placebo group [relative risk (RR), 0.90; 95% confidence interval (CI), 0.82–0.98; P = 0.02]; 16.4% of patients on treatment and 17.5% of patients in the placebo arm died of cardiovascular causes (RR, 0.93; 95% CI, 0.81 to 1.06); 27.4% of patients on treatment and 29.6% in the placebo group were hospitalized for HF (RR, 0.90; 95% CI, 0.81–1.00).
A negative correlation was observed between the left DTI-ALPS index and HbA1c, but this result did not reach statistical significance after multiple comparison correction (r = −0.508, p = 0.021).
Although the CRP level decreased, it did not reach statistical significance ( p = 0.022).
Although SIRT1 levels were increased in the Se group compared to the control group, it did not reach statistical significance. In the CS group, an increase in Bax expression and a decrease in Bcl-2 and PGC1-α expressions were observed compared to the control group ( p = 0.023, p = 0.011, p = 0.003; respectively).
However, although a benefit in median PFS was observed, it did not reach statistical significance: median PFS was 6.5 months (95% CI, 5.7-6.9) in the experimental arm and 5.6 months (95% CI, 5.1- 6.6) in the control arm (HR, 0.86; 95% CI, 0.75-1.00; P =0.023).
However, it is important to note that this value did not reach statistical significance ( p = 0.023).
The study did not reach statistical significance in the intention-to-treat population, with a median PFS of 5.7 months for selinexor versus 3.8 months for the control arm (HR 0.70; p = 0.024).
mansoni -infected groups for cTfh17 cells pre-vaccination did not reach statistical significance, they were significantly lower in S . mansoni -infected individuals at M12 post-vaccination (no vs. low P = 0.024, no vs. high P = 0.006) ( Fig 4E ).
Efficacy ORR was 82.5% (95% CI, 76.9-87.2) in the once-weekly KRd56 group vs 86.3% (95% CI, 81.1-90.5) in the twice-weekly KRd27 group (risk ratio [once-weekly KRd56/twice-weekly KRd27] = 0.954 [95% CI, 0.882-1.032]; P = .0666; Table 2 ), which did not reach statistical significance for noninferiority at the prespecified alpha threshold of P ≤ .025, 1-sided.
did not reach statistical significancep -value = 0.025
We also found that CD14 monocytes (also known as classical monocytes) were expanded in the ALS blood, however, our analyses did not reach statistical significance after correction for multiple comparisons (fold change = 1.48; p -value = 0.025; adj. p -value = 0.36).
They also showed more interest in constructive and creative activities such as model airplanes and Legos (48.93% vs 6.66%), although this difference did not reach statistical significance after applying the Bonferroni correction (p=0.025).
On the basis of protocol-prespecified Hochberg step-up multiplicity adjustment, the primary end point did not reach statistical significance ( P < .025).
Gentle parents reported more satisfaction ( M = 4.15, SD = 0.96) than did non-gentle parents ( M = 3.73, SD = 0.92), although the difference did not reach statistical significance with the Bonferroni correction, t (98) = 2.26, p = 0.026.
At 0.55T, however, greater error for the ST segment did not reach statistical significance after Bonferroni correction (0.14 mV ST error vs. 0.07 mV PR error, p = 0.026).
Moreover, the HLA-DR score for UM with no-low pigmentation was lower than in moderately pigmented and heavily pigmented UM, even though the latter comparison did not reach statistical significance (no-low vs. moderate pigmentation: p = 0.027, no-low vs. heavy pigmentation: p = 0.053) ( Supplementary Figure S1e ).
did not reach statistical significancep = 0.0288
The interactions for time*trial ( F = 1.541, p = 0.2225), group*trial ( F = 4.158, p = 0.0556), and time*trial*group ( F = 0.192, p = 0.9421) did not reach statistical significance; however, there was a significant time*group interaction ( F = 2.863, p = 0.0288) (Figure 4c ).
When stratified by study design (RCT or OL), the CES of RCT studies tended towards symptom improvement; however, it did not reach statistical significance (Hedges g = 0.35, 95% CI = −0.04 to 0.74, p = 0.03, I 2 = 53.79%; Fig. 3 - Blue Dots).
A similar trend was observed in AML (22.7% vs 18.7%; P = .58) but did not reach statistical significance in part due to the higher prevalence of seropositive RA in AML compared with MDS (78% vs 29%; P = .03), and the lack of association of seropositive RA with IDH mutation.
Although this did not reach statistical significance, when WAI variables were transformed to correct for skewness, the interaction was significant ( p = .03).
Children from middle SES families had lower alpha asymmetry (i.e., reduced right hemisphere alpha power) compared to low SES children, but this did not reach statistical significance ( p = .030).
While the difference in NPY expression between BP and PIN did not reach statistical significance, NPY EI was significantly higher in PCa than BP ( p = 0.03) and NPY expression in PIN did not differ significantly from invasive cancer ( p > 0.99, Fig. 6 ).
did not reach statistical significancep = 0.0301
Even though the interim OS results of MONARCH-3 did not reach statistical significance (HR = 0.754, 95% CI 0.584–0.974, p = 0.0301), its absolute value is also very impressive, reaching 67.1 months.
did not reach statistical significancep = 0.0309
It was also noted that the changes in several ABPM indicators of the ALI/AML group did not reach statistical significance compared to the AML group (except for changes in the daytime DBP between the two treatment groups, p = 0.0309).
In the present study, the effects of upper- and lower-body exercise trials on fat oxidation rates on day 2 were comparable, although differences between the lower-body exercise and control trials did not reach statistical significance (upper-body exercise trial: ES = 0.459, 95%CI 0.00 to 0.03, P = 0.031; lower-body exercise trial: ES = 0.436, 95%CI –0.03 to 0.00, P = 0.061).