“did not reach statistical significance”

In this study, patients who received radiotherapy during systemic treatment showed a trend toward improved iPFS compared with those who underwent radiotherapy prior to starting this regimen (P = 0.058), although this did not reach statistical significance due to the retrospective design and limited sample size( supplement Figure2 ).

Although tumor invasion of the ventricle showed a strong trend, it did not reach statistical significance in the multivariate model (OR = 6.21, 95% CI: 0.94-41.15, P = 0.058).

Although the mediation effects for SDoH = 1 and SDoH = 2 did not reach statistical significance, it was noteworthy that the effect for SDoH = 2 approached significance for both mortality outcomes ( P = 0.058).

In contrast, beta-blockers showed a trend toward a protective effect (OR: 0.47, 95% CI: 0.22–1.03, P = 0.058), though this did not reach statistical significance.

A notable trend was observed between the groups after the 12-week intervention period when comparing the change in area under the curve (ΔAUC) for glucose ( p = 0.058); however, this result did not reach statistical significance.

Although the difference approached significance, it did not reach statistical significance ( p = 0.058).

Carer psychological distress showed a positive trend in its association with increasing PLWD unmanaged symptoms (coefficient = 0.07, 95% CI [−0.00, 0.13], p = 0.059) and agitation (coefficient = 0.06, 95% CI [−0.01, 0.14], p = 0.090), but both analyses did not reach statistical significance.

A favorable trend was also observed for overall survival (OS) (HR = 0.75, 95% CI: 0.55-1.01, P = 0.059, Figure 3F ), although this did not reach statistical significance.

The root extracts showed a trend toward increasing CASP9 expression ( p = 0.059), but this did not reach statistical significance, meaning that while there might be a potential effect, the data do not provide strong enough evidence to confirm a reliable upregulation at the tested doses.

While a positive trend was observed between GRS and fasting C-peptide (β = 0.0228), this association also did not reach statistical significance (p = 0.059).

RFDR showed a tendency toward significance (F = 2.893, p = 0.059, η 2 = 0.048) but did not reach statistical significance after adjustment.

However, the difference in AST and ALP did not reach statistical significance ( p = 0.378 for AST, p = 0.190 for ALP), while GGT showed borderline significance ( p = 0.059). 3.4 WQS regression The eight components that make up the LE8 score were evaluated for their impact on these liver function parameters ( Figures 3A – E ).

Although post hoc comparisons did not reach statistical significance after Bonferroni correction, a clear trend toward higher TAN counts was observed in the c-erbB2-positive group compared with the c-erbB2-negative group (mean rank = 36.65 vs. 28.91, p = 0.059) ( Table 4 , Chart 4 ).

Hypertension without heart disease showed a trend towards increased risk with delayed surgery (HR = 2.05, p = 0.06), but this did not reach statistical significance, as shown in Table 7 .

Assessment of hepatic triglyceride levels confirmed that HFD-fed mice had significantly higher liver triglycerides compared to Chow-fed mice ( Fig 4B ) (p < 0.01) but HCD-fed mice only showed a trend towards higher liver triglyceride content, which did not reach statistical significance (p = 0.06).

For extension, an increasing trend was noted (from 54.80° ± 10.58 to 59.87° ± 4.61; p = 0.06), although the difference did not reach statistical significance.

Knowledge score, while showing a positive trend, did not reach statistical significance in the multivariable model (OR = 1.181, 95% CI: 0.993–1.404, p = 0.060).

This increase did not reach statistical significance (Chi-squared 3.718, p = 0.052); a similar borderline significant increase was observed using time series analysis (0.13 percentage points per month, 95% CI: -0.007 to 0.268, p = 0.06).

The overall pooled estimate across both time points showed a trend toward improvement that did not reach statistical significance (mean difference: 21.27, 95% CI: −0.96 to 43.50, p = 0.06), with substantial heterogeneity observed ( I 2 = 80%, p = 0.03).

In the multivariate logistic regression analysis, male gender showed a trend toward being a risk factor for complicated appendicitis ( p = 0.06), but this did not reach statistical significance.

In the operated hip, patients in the decreased offset group showed a trend toward lower strength compared to those with restored offset (d = -2.00, p = 0.06), though this did not reach statistical significance.

Whereas we found that male sex demonstrated a statistical trend towards association with increased odds of meeting the ASES PASS cutoff (OR, 1.79, P = .06), this did not reach statistical significance.

However, in the validation set, the dual-phase model showed a trend toward higher AUC than the NP model for LR (ΔAUC =0.211, P=0.06) and SVM (ΔAUC =0.159, P=0.10), although these differences did not reach statistical significance.

However, these changes did not reach statistical significance, although they approached significance ( p = 0.06–0.08), likely due to the limited sample size ( N = 34 of the 60 children enrolled), as 26 participants had missing paired pre- and post-supplementation values and therefore could not be included in the comparative analysis.

While fresh EVs were used as a positive control and showed a clear trend toward increased organoid formation, the differences did not reach statistical significance ( p = 0.06), likely due to the variability inherent in primary cell cultures.