In the second half of the study period (i.e., from V4 to V6), Sequence 1 (i.e., HA-first) showed a trend toward lower OSDI scores (p = 0.056) that did not reach statistical significance.
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In the literature
The pre-dementia group had fewer hospital visits related to pancreas cancer (IRR = 0.82, 95% CI: 0.69–0.98, FDR-adjusted P = 0.010), and showed a trend toward fewer visits for colon cancer (IRR = 0.95, 95% CI: 0.91–1.00, FDR-adjusted P = 0.056), though it did not reach statistical significance.
The presence of arthritis showed a trend toward association (OR=5.191, 95%CI:0.960–28.065, p=0.056) but did not reach statistical significance.
Additionally, the interaction between time × APOE ε4 status showed a trend toward significance ( F [1,90] = 3.736, p = 0.056, partial η 2 = 0.040), suggesting that the decline in distress over time may have been moderated by genetic risk, although this effect did not reach statistical significance. χ 2 Tests examined whether behavioral adaptations (yes/no) differed between the online and onsite intervention groups at 3 and 6 months.
Although pathological stage and perineural invasion showed a borderline significant relationship with DFS, these relationships did not reach statistical significance ( p = 0.056 and p = 0.059, respectively).
Contrary to expectations, our study showed that the mediating effect of FT on the DII-S-Klotho association did not reach statistical significance, but displayed a trend towards significance after controlling for confounding factors (p = 0.056).
We observed an adverse trend effect among males ( p = 0.056) and a protective trend effect among females ( p = 0.073) in the verbal memory domain, although these observations did not reach statistical significance.
showed a trendp = 0.056
In HFD-fed Mlkl Adi-KO mice, valine levels were significantly reduced compared to WT controls, while leucine showed a trend towards reduction that did not reach statistical significance ( p = 0.056).
showed a trendp = 0.056
Sjögren syndrome showed a trend toward lower prevalence in the family-history group that did not reach statistical significance (1.3% vs. 4.5%; p = 0.056).
Results CRISPR/Cas9 treatment targeting miR-21 showed a trend toward reduced miR-21 expression (p = 0.0563), although this did not reach statistical significance.
Although the association between total training sessions and DBP improvement showed a negative trend, it did not reach statistical significance (β = −0.0340, p = 0.0565), implying that increasing the number of sessions may contribute to DBP reduction, but the evidence remains insufficient.
showed a trendp = 0.0567
Although NEC + HD animals showed a trend toward reduced weight gain compared to NEC, this difference did not reach statistical significance ( p = 0.0567).
The risk of death was also reduced but did not reach statistical significance, although it approached significance in women older than 40 years (p = 0.057).
approached significancep = 0.057
While this model did not reach statistical significance; perspective taking was the only variable that approached significance, ß = 0.388, t = 1.99, p = 0.057.
There was a clear trend towards significance in the association between high SERPINE1 expression and poor patient survival (HR 1.78, 95%CI 0.98–3.23, p = 0.057), however the differences observed among groups, did not reach statistical significance in the multivariate analysis.
Although a negative trend was consistently observed, it did not reach statistical significance in either regression model (OLS: R 2 = 0.16, p = 0.057; robust: R 2 = 0.25, p = 0.059).
Finally, in the analysis of the total MFI score, as shown in Supplemental Figure S4a and b, blood samples showed a suggestive trend toward an association with homocysteine degradation (Holm p = 0.057, FDR = 0.032), although this did not reach statistical significance.
showed a trendp = 0.057
Close margins showed a trend toward increased risk that did not reach statistical significance (hazard ratio 2.18, 95% CI 0.98–4.86, p = 0.057; 8 events among 38 patients), likely reflecting limited statistical power given the small number of events.
Although flossing habits showed a trend toward significance ( p = 0.057), the association did not reach statistical significance.
borderline significanceP = 0.057
Although the crude relapse rates appeared different between the two treatment groups, the difference did not reach statistical significance (borderline significance, P = 0.057).
Although a strong trend toward a better outcome was observed in the surgical cohort, this difference did not reach statistical significance ( P = 0.057; OR = 3.857).
showed a trendp = 0.057
Although Q3 showed a trend toward reduced mortality risk relative to Q2, the association did not reach statistical significance (HR: 0.62, 95% CI: 0.38–1.01, p = 0.057).
We found Diet had a strong trend towards reducing the F/B ratio ( p = 0.0574) but it did not reach statistical significance (Figure 3c ).
showed a trendp = 0.058
Although unmarried patients showed a trend toward worse DSS, this finding did not reach statistical significance (HR = 1.285, p = 0.058).
Women with normal weight (18.5 ≤ BMI < 24.0 kg/m 2 ) also showed a trend toward reduced risk (OR = 0.73, 95% CI: 0.53–1.01, p = 0.058), although this did not reach statistical significance.