“highly significant”

The correlation levels are moderate, yet highly significant ( p -values < 2.2 × 10 −16 ), therefore it is likely that these different measures highlight the same underlying core phenomenon.

A Chi-square test comparing the observed and expected frequencies of different types of AA combinations gave a highly significant result for data pooled across phyla (X 2 = 255.35, df = 2, P < 2.2×10 −16 , Table 1 ).

Before harmonization, a Type III ANOVA revealed a highly significant site effect on global mean connectivity (F(12, 623) = 9.65, p < 2.2 × 10 −16 ).

All correlations were highly significant (for all: P < 2.2 E-16; more details on performance estimates and model statistics, see Text S1 in the Supplementary Material).

We observe a highly significant 3-way MT × N × E interaction ( P << 2.2 × 10 −16 ) ( Table 1 ) and highly significant MT × N epistasis within each of the 6 conditions ( Table 2 ).

The power of per-gene testing was constrained by sample size, but results were highly significant (Fisher Exact p-value < 2.2e-16) when variants were combined across all genes [Table S8].

Before this correction, this correlation was strong and highly significant for the 800 μM HFF-TerT sample (Figure 6B , Spearman's ρ = 0.29, P < 2.2 × 10 −16 , asymptotic t test).

Consistent with this, many of these genes (80/173) were also downregulated in the DIG1 residual profile, a highly significant enrichment (Fisher’s exact test, 1-tailed: P < 2.2e−16).

The model describing recovery rate ( rr ) was highly significant ( X 2 = 27,605,272, df = 23, P< 2.2e -16 ), with each term of the model being significant ( S2 Table ).

We observed a very weak but highly significant correlation in synonymous heterozygosity between species (Pearson’s r = 0.14, p<2.2e-16), consistent with some degree of conservation for genic parameters of mutation rates and/or selection at Drosophila synonymous sites [ 58 , 70 – 74 ].

Given that only 0.6% of all high-coverage sites were within 10 kb of a known imprinted locus, this is a substantial (29.3-fold), and highly significant enrichment of ASHM sites around imprinted regions ( P < 2.2 × 10 −16 , χ2 test).

In both cases the difference in expression level was highly significant ( p < 2.2e-16) indicating that the coverage of those genes was too low for an assembly of at least 55% in one species.

This correlation was highly significant ( p < 2.2 × 10 −16 ), indicating that the observed similarity is unlikely to occur by chance. 2.4 Expression of PAMPs and DAMPs in Human and Murine pDCs Quantitative proteomic comparison of human and murine plasmacytoid dendritic cells (pDCs) revealed selective, pathway‐specific differences rather than global proteome shifts.

Lastly, we compared the average TE ages between SUO and SLO genes in human and revealed a highly significant difference (p<2.2e-16, Wilcoxon Rank Sum test), with the former at 16.1% and the latter at 21.3% sequence divergence from their consensus sequences (For reference, 16–18% of unconstrained nucleotides have been substituted since the split of primates from other mammalian orders [32] ).

Among these were 20.0% of the genes upregulated in XY° males (993 out of 4973) versus 40.8% of the genes upregulated in XX females (3856 out of 9472) in at least one developmental stage (FDR < 0.05), a highly significant difference ( χ 2 = 330.0, p < 2.2e−16).

Fisher’s exact test revealed a highly significant association between treatments and inhibition scores at both 24 hpi and 96 hpi ( p < 2.2 × 10 −16 ).

In fact, the least significant (i.e., highest) p -value observed in any factorial ANOVA corresponded to a main effect term (intrinsic disorder in Plants: p = 4.13 × 10 −6 ), while all other terms across all analyses were highly significant ( p < 2.2 × 10 −16 ).

Supporting this hypothesis, a comparison of the mean coverage of the nuwt regions to that of the non-nuwt regions showed a small but highly significant difference between them (Wilcoxon rank sum test with continuity correction, p < 2.2×10 -16 for all 13 samples).

The correlation between ω A MK and DoS was strong and highly significant (ρ = 0.964, P -value < 2.2E-16, n = 10,631, supplementary fig.

Food Deserts: In stark contrast, the food desert index showed a strong and highly significant positive spatial autocorrelation (I = 0.4563, p < 2.2 × 10 −16 ).

Results Phenotypic variance decomposition and heritability of partial resistance to bacterial canker Considering differences between all controls and inoculated shoots regardless of the genotype effect, a highly significant effect of bacterial inoculation was observed (Wilcoxon unilateral t.test p < 2.2E-16) for lgc whatever the year and for bs in 2013 and 2015 (lesser extent in 2014 p < 9.77E-12 and 2016 p < 9.06E-06).

The effect of the fly strain on CCRT was highly significant (Kruskal–Wallis test, p < 2.2 × 10 −16 ).

The fitted model yielded LOD scores of 55.8, 41.1, and 45.7, and PVE values of 77.0%, 66.1%, and 69.9% in 2021, 2022, and 2023, respectively, with all effects being highly significant ( P < 2.2 × 10−16) (Table S5 ).

Conservation and compensation of phosphosite loss by site-position turnover Surprisingly, despite the low level of site-conservation between paralogous proteins, there is a highly significant correlation in the number of phosphorylation sites between paralogs (ρ=0.35, P -value<2.2 × 10 −16 ; Figure 1B ).

When comparing the log 2 FCs obtained for all genes and contrasts between qRT-PCR and array we found a highly significant correlation (pearson correlation of r = 0.96, p = 2.2e -16 and an R 2 = 0.92).