“highly significant”

One such QTL, lsq4 on chromosome IV, appeared in three different inter-strain crosses as highly significant linkage-mapping peaks for longevity (each P < 10 −9 ) (Ebert et al., 1993 , 1996 ; Ayyadevara et al., 2001 , 2003 ; Shmookler Reis et al., 2007 ).

The five most highly significant (FDR P = 1 × 10 −9 ) Gene Ontology (GO) terms for biological process relate to immune system activation and regulation (Supplementary Data 12 ).

A t -test comparing scores against 0 demonstrated that this behavioural effect was highly significant ( t = −8.58, p < 10 −9 ).

Genome-wide, SLC39A8 (p<4.3×10 −10 ) was one of only 19 genes that passed a combined highly significant statistical association (p<10 −9 ) with tumor aggressiveness [73] .

It was found that the proportion of the depressed elderly population in India (18.2%) was significantly higher than the rest of the world (5.4%) and this difference was found to be statistically highly significant (x 2 =770.4 and P =.000000001).

3 , Table 1; supplementary material Table S2 ). The gene ontology analysis of the recent human dataset ( Tsankov et al., 2015 ) included few highly significant terms ( P -value <1×10 −9 ) ( supplementary material Table S2 ).

However, TR ratings and investments were highly correlated in both conditions (mean linear correlation coefficient r = 0.65 in EC and 0.61 in CC, corresponding to P -values smaller than 10 −8 in both cases) and correlations were also highly significant between TR ratings and ERs (mean r = 0.72 in EC, 0.69 in CC, P < 10 −9 ).

Furthermore, while V600E BRAF mutations (over 10,000 described) occur in a mutually exclusive manner with RAS mutations, four of the 34 kinase-dead mutants are coincident with RAS mutations, a highly significant enrichment (p < 10 −9 ; Fisher's Exact Test) that suggests functional interaction.

An analysis of overrepresented GOs amongst the DEGs (5-fold difference) showed a highly significant enrichment of GO terms ( p < 10E−10), such as ‘neuron migration’, ‘collagen fibril organization’ and ‘anterior/posterior pattern specification’.

However, when 1000 WBC were analysed, blasts were detected in 33/37 (89%) of MDS samples compared with 6/30 (20%) of age‐matched controls, a highly significant difference ( p < 10 −9 ).

Results We detected highly significant associations of obesity with alleles in all three SNPs (p < 10 -9 ).

The Kruskal–Wallis test confirmed highly significant global heterogeneity (H = 94.31, p < 10 −9 ).

In the infants with confirmed CMPA, there was a highly significant reduction in CoMiSS from 8 (IQR 6–11) to 5 (IQR 3–7) from baseline to visit 2 (p<0.000000001), with a median reduction by −3 (IQR −6 to −1).

The latency of this response was faster for faces presented in the proximal than in distant condition (1467 ± 66 and 1690 ± 59 ms respectively) and this difference was highly significant (F = 52.0, p < 10 –9 , Fig. 2 C).

By another GEE, we observed the expected highly significant relation ( p < 10 −9 ) between the histology‐based and MRI‐based measurement of cortical thickness (see Fig 5 ).

6B , the predictions were highly significant at the whole-cortex level ( r =.64, p <10 −9 ).

When compared with CON mice, both G HP E and GE mice showed a highly significant reduction of dendritic branching of hippocampal pyramidal neurons (condition effect, P < 1 × 10 −9 ) ( Fig. 4 A ).

First, two highly significant ( p < 10 −9 ) SNPs were found in the intron of krishah ( kri ), and two additional SNPs with slightly lower significance ( p < 10 −7 ) were found in the 5′ untranslated region (UTR) of kri ( Figure S3 ). kri is tightly clustered with the genes S6k and mad2 ( Figure S3 ).

This increase in responsiveness with depth was highly significant ( R 2 = 0.70, p < 10 −9 , linear regression, n = 35 imaged regions in seven mice; Fig. 2 A ; Table 1 ) and was observed in every animal tested ( Fig. 2 A ; Table 1 ; R 2 > 0.79 and p < 0.04 for all animals, n = 5 regions per animal).

Correlation in log fold-change among genes between the two environments was highly significant ( P = 1 × 10 −9 ) but weak ( r = 0.1).

To corroborate this finding, we next performed co-localization studies and confirmed that extracellular colocalization of IgG with HEV ORF2 protein was statistically highly significant (p < 10E-10; Fig. 3a and Supplementary Fig. 2b ).

If we regress the alt-allele frequency in reads from heterozygotes (y-axis of Fig 3B ) onto the estimates for both a and d simultaneously, both are highly significant as positive predictors of allele frequency (p < 10 −9 for each coefficient).

It was found that the proportion of depressed elderly population in India (18.2%) was significantly higher than the rest of the world (5.4%) and this difference was found to be statistically highly significant (χ 2 = 770.4 and P = 0.000000001*).

Sets of 1,049 and 969 genes (out of the total of 14,405 represented on the microarray), were found to be modulated in hippocampus and cortex, respectively, the intersection of the two sets consisting of 619 genes, a highly significant number (P<10 −9 ) ( Figure 5A ).

This model performed slightly (although highly significant: P < 1*10 −9 ) better than Model 1.