“highly significant”

p value of F‐statistics was highly significant ( p = 7.049e‐10).

The increase in probability of violation associated with having predecessors is highly significant (Fisher’s exact test; p = 7.2 × 10 −10 ).

Overall, in the ILR analysis, there was a highly significant difference between cohorts (generalized Wald test; P = 7.234e−10), with greater signature 3 exposure in the early-stage cohort and more signature 4 in the late-stage cohort ( Fig. 4C ).

The differences in fitness observed between the two medium types were highly significant ( p = 7.37E-10).

The result for the same risk allele (T) remained highly significant (Hazard Ratio=2.27, CI = 1.75–2.95, p = 7.8 × 10 −10 ).

This model indicated a highly significant effect of gaze, SE = 0.13, z = −6.146, p = 7.95 × 10 -10 , and no effect of shadow, SE = 0.084, z = −1.244, p = .213.

Similarly, the interactions between the two fruit fly species and the temperature regimes were found to be highly significant for adult fecundity (F = 11.85; d.f. = 5, 168; P = 7.97x10 -10 ).

We identified 527 highly significant (p < 8 X 10 −10 ) pQTLs in 38 (43%) of blood proteins tested.

The promoter SNP rs2070895 showed a highly significant association with a 0.057 mmol/l increase in HDL-C per A allele ( P = 8 × 10 -10 ) [ 24 ].

5.a and 5.b ), the difference between strong and weak sites is also highly significant (T-test P value = 8.0 10 -10 for proximal strong sites vs. proximal weak sites).

The non-linear correlation (| r |=0.32) between the sum of free terpenoids and surface conductance was highly significant (adjusted P =8.09e-10).

Moreover, the probability of a right-handed turn (given hereafter as π) based on the GLM was 0.621, a highly significant difference (p = 8.2×10 −10 ) from that expected for random turning (π = 0.5).

Analyses of differential expression of the genes through the FUMA pipeline 37 recapitulated these findings, indicating highly significant (minimum P = 8.4 × 10 −10 ) upregulation in prenatal brain tissue and downregulation postnatally for the first cluster, and vice versa (minimum P = 1.1 × 10 −11 ) for the second cluster, see Supplementary figure 3 .

GS male ranged between 3 and 12 with a GRR associated to 1 point increase in the score of 1.23 ( P = 2.2 × 10 -6 ; 95% CI 1.13 to 1.34) and GS female ranged between 4 and 14 with a GRR of 1.41 ( P = 1.9 × 10 -5 ; 95% CI 1.21 to 1.65) for a highly significant global test with P = 8.4 × 10 -10 .

Meta-analysis of the stage 1 and 2 datasets also produced highly significant evidence of association (rs11136000: p= 8.5×10 −10 , OR = 0.861 and rs3851179: p= 1.3×10 −9 , OR= 0.859, two-tailed, Table 1 ) for CLU and PICALM loci respectively.

This was highly significant ( χ 2 =37.6, P =8.6 × 10 −10 , 95% CI (1.62, 2.53)).

A two-way Scheirer–Ray–Hare test revealed highly significant difference between SWN and no normalization ( p = 8.70 × 10 − 10 ), indicating that the effect of SWN is consistent across methods.

The differential expression in RC disease between these 261 target genes and all non-target genes was highly significant (p = 8.8×10 −10 in muscle and p = 5.5×10 −35 in FCLs) ( Fig.

Although these variants did not reach statistical significance individually, the results were highly significant when they were combined (OR = 3.72; 95% CI = 2.38–5.82; p = 8.9 × 10 –10 ) ( Vallet et al., 2015 ). 22 distinct variants were recently identified in a Belgian population.

When the Class II and Class III SNPs were included in the logistic regression model, the rs4959039 SNP retained a highly significant association with MS susceptibility ( p = 9.70×10 −10 , odds ratio = 1.52).

A similar evaluation of the CONTROL gene set suggested a highly significant overrepresentation of different intracellular processes, such as extracellular matrix (ECM) receptor interaction ( p = 0.000000000976—BIOPLANET and p = 0.00000000616—KEGG), Beta-1 integrin cell surface interactions ( p = 0.000000437—BIOPLANET), ABC transporters ( p = 0.0000307—BIOPLANET), and various other transmembrane pathways ( Figure 2 b).

The Kruskal–Wallis test confirmed highly significant global heterogeneity (H = 94.31, p < 10 −9 ).

Together these show that four of the genes investigated ( HLA-C, IL12B, TNIP1 and IL23A ) show highly significant differences in expression levels between involved and uninvolved skin (all with p < 10 −9 ).

The five most highly significant (FDR P = 1 × 10 −9 ) Gene Ontology (GO) terms for biological process relate to immune system activation and regulation (Supplementary Data 12 ).

However, TR ratings and investments were highly correlated in both conditions (mean linear correlation coefficient r = 0.65 in EC and 0.61 in CC, corresponding to P -values smaller than 10 −8 in both cases) and correlations were also highly significant between TR ratings and ERs (mean r = 0.72 in EC, 0.69 in CC, P < 10 −9 ).