“highly significant”

Species Response Curve (SRC) The analysis clearly indicates highly significant differences ( p < 0.00001) for increased population variable (conservation status) in comparison with all other variables due to their maximum frequency as shown in Figure 2A .

The terms for DNA-binding transcription activator activity (RNA polymerase II-specific) and actin binding were highly significant ( p = 1.0 × 10 −5 ), as was microtubule binding ( p = 2.0 × 10 −5 ).

The heterogeneity test indicated a highly significant variance ( P < 0.00001, I2 = 94%), thus indicating the application of a random-effects model for the analysis.

Among the top most highly significant pathways ( P < 1.0 × 10 − 5 ) included the pathways involved in MSP-RON, PDGF, molecular mechanisms of cancer, STAT3, prostate cancer, P53, MYC mediated apoptosis, IGF-1, NF-kB, Androgen biosynthesis, PTEN and IL-6 signaling pathways (Fig. 5 ).

Between the Non-Gly and the Gly subtypes, we identified 763 highly significant Differentially Expressed (DE) genes (Adj. p < 1E-05), 296 of which over-expressed in Gly subtype and 466 over-expressed in the Non-Gly tumors ( Figure 2A and Supplementary Table 3 ).

norvegicus was highly significant (P-value <0.00001) by regression of shape onto centroid size for both dorsal and ventral views.

A total of 21 children with PSTC and 518 children with migraine showed that drawings had similar features except one-third (28.6%) with PSTC depicted diplopia which was highly significant ( P = 0.00001).

The test for overall effect showed a highly significant result ( Z = 4.74; p < 0.00001), indicating that fever was significantly more likely in individuals receiving VLA15 than those receiving placebo.

S3C ), there was a highly significant difference between all groups when clustered by degree of substrate consumption (Kruskal–Wallis p value <0.00001; Fig.

Here, we detected a total of six highly significant association signals ( p < 1 × 10 −5 ) for i-LT, corresponding to five unique genes, consistent with a previous report ( Supplemental Table 7 ) ( Wei et al., 2018 ) and suggesting the potential importance of these candidate genes for final PH in maize.

The difference between the number of reading mistakes before and after the training session was highly significant (Wicoxon Test: p < 0.00001).

Correlation analysis across six independent bulk transcriptomic cohorts (TCGA-PAAD, ICGC-PAAD-CAseq, GSE85916 , GSE79668 , GSE71729 , and EMTAB6134) demonstrated a highly significant positive association between THBS2+ CAF signature scores and T-cell exclusion scores (all p < 1 × 10−5), indicating that tumors with high THBS2+ CAF infiltration exhibit restricted T cell access to tumor nests ( Fig. 4 B).

The interaction effects on breast cancer risk of these five TF pairs were all highly significant ( P < 1 × 10 −5 ; Supplementary Data 2 ).

Association between clinical severity and age groups was highly significant (p-value <0.00001) as presented in Table 4 .

At a general hospital level, Hellgren et al., retrospectively analyzing data from 83 patients with RRMS, PPMS, and SPMS, reported a highly significant reduction of ARR induced by rituximab (500 or 1,000 mg every 6–12 months) from mean 0.38 ± 0.5 before treatment initiation to mean 0.05 ± 0.19 at follow-up (p<0.00001), with a global reduction by 87% ( 82 ).

Correlation analysis between the co-expression module and traits was carried out, and two highly significant trait-related modules (|cor| > 0.75, p -value < 1 × 10 −5 ) were identified.

In unadjusted models, all indices maintained highly significant associations ( P < 10 −5 ), indicating predictive capacity beyond shared variance.

Results Copper levels were higher in group II showing statistically highly significant results compared with that of group I with p ≤ 0.00001.

Again, the difference is highly significant ( P -value < 0.00001).

They found a highly significant difference in mean %EWL of 17.98% (95%CI: 8.37-27.58, P < 0.00001) in the balloon group in comparison to the sham/life-style modification group.

Overdose showed significant reductions from pre-operative to post-operative measurements, and the Nemo prognostic model was close to the final post-operative condition as reflected in the highly significant ANOVA (F = 13.66, p < 0.00001).

The differences are relatively constant across the subjects, and a paired student's t test returned a highly significant difference between the two conditions (P < 10 −5 ).

However, since there are only around 80 confirmed and 120 predicted imprinted loci in total in the human genome, the observation of even just ten of these genes in our study represents a highly significant enrichment ( P < 1 × 10 −5 ; permutation test).

There was a highly significant correlation in the methylation status of the MGMT promoter region and MGMT protein expression ( p < 0.00001, Fisher exact test).

Astrocyte and endothelial expression appears normal, while highly significant down-regulation of Oligodendrocyte genes was found in the Caudate Nucleus ( p < 0.00001, 0 d ( γ X , γ D ̄ ) = 13 . 1 ), Cingulate Cortex ( p < 0.00001, d ( γ X , γ D ̄ ) = 11 . 6 ), Hippocampus ( p < 0.0057, d ( γ X , γ D ̄ ) = 4 ), Middle Temporal Gyrus ( p < 0.0001, d ( γ X , γ D ̄ ) = 5 . 7 ), and the Temporal Pole ( p < 0.0001, d ( γ X , γ D ̄ ) = 8 . 2 ).