“highly significant”

We searched for differentially methylated regions (DMR) where 100 adjacent CpG sites on the BeadChip are regulated accordingly—only two genomic regions revealed such a highly significant enrichment of SA-DNAm changes ( P < 10 −5 ): the HOXB locus on chromosome 17 (SA-hypermethylated) and the keratin associated protein (KRTAP) locus on chromosome 21 (SA-hypomethylated; Supplemental Fig. 3).

5 ) in test 1 and 61% in Test 2; “Treatment*Pre/Post” was negative and highly significant ( P < 10 -5 ; Additional file 6 : Table S2; Additional file 7 : Table S3).

Given that these numbers were drawn from genome-wide measurement of 20,722 genes, the enrichment on plasma cell signature genes is highly significant ( p < 10 − 5 , Fisher exact test).

Highly significant differences were observed between susceptible and resistant UTI groups ( p = 0.00001 and p = 0.000015, respectively), indicating BCG cycles as a key differentiating factor.

Larger F ST and highly significant values were observed when distance matrices based on the U20_BFDSC genotypes were compared with those of East or South Asian and African populations ( p < 0.00001) ( Table 2 ).

However, the Bray-Curtis dissimilarity between the two data is highly significant, using the two-sided t -test with p-value <10 −5 .

Effect of SR on HR Figure 2 shows that the effect of SR is highly significant, although clinically small: 1.65 bpm [95%CI: 1.19, 2.11], p < 0.00001, random effect, or 1.40 bpm [95% CI: 1.05, 1.75], fixed effect.

In DHLF-COPD the Mann-Whitney U test showed a highly significant difference in distributions (U = 41246, p = 1.01 × 10 −5 ) and Mood’s Median Test confirmed a significant difference in medians (χ 2 = 15.82, p = 7 × 10 −5 ) comparing control and treatment group while in NHLF no significant correlation could be detected (Fig. 6 A).

The correlation between the ranking of amino acids of Figure 4 A and the one in Figure 5 E was highly significant (ρ = 0.81; p = 1.03 × 10 −5 ), despite the limited number of epitopes with available X-ray structures used to estimate amino acid frequencies in Figure 5 E.

Here, an equivalent time point comparison at 15 min revealed that CBD invoked a highly significant negative shift in Va from a baseline value in control recordings of Kv7.2 wt + Kv7.3 of −29.8 ± 1.25 mV to −35.6 ± 1.36 mV (n = 8; p = 1.06 × 10 −5 ) in CBD ( Figure 5 A).

Indeed, when we compared the South African and Canarian goats with the remaining populations, estimated F ST coefficients were moderate (F ST = 0.06–0.14) but highly significant ( P < 1.10 −5 ).

Under this model, the transition from Tanner breast stage 2 to 3 was associated with a highly significant increase in logit-transformed LAB proportions ( P = 1.1E-05), while subsequent transitions to stage 4 and 5 had relatively small effects ( P = 0.26 and P = 0.56, respectively [ Table 2] ).

We mapped the regional presentation score of the most highly represented protein in the neuroblastoma ligandome, NPY (29 MHC Class I peptides detected in 16 neuroblastomas), finding a highly significant concordance between the empirically detected peptides and those regions of the protein expected to be highly presented ( Figure 3E ; p = 0.000011), and find no peptides in the ligandome derived from the signal peptide region (aa 1–28) which is cleaved from the full-length pro-NPY protein.

The OPLS-DA model showed a good fit (R 2 = 0.65), predictivity (Q 2 = 0.55) and a highly significant CV-ANOVA ( p value = 1.1E −5 ).

The Wilcoxon rank-sum pairwise tests confirmed this trend within light settings: the differences between paired control and positive-trained groups were highly significant in all light conditions (G: Z = 4.395, p = 1.107 × 10 −5 , Holm-adjusted p = 2.214 × 10 −5 ; B: Z = 2.904, p = 0.004, Holm-adjusted p = 0.004; G&B: Z = 4.813, p = 1.484 × 10 −6 , Holm-adjusted p = 4.453 × 10 −6 ).

The P -value of the meta-analysis of 3 independent datasets was highly significant (mean OR, 0.4; P =1.11E-05), which indicates that hypercholesterolemia tended to occur in women without adenomyosis.

Finally, a PPI network analysis in the STRING confirmed a highly significant interactions, highlighting the biological interconnectivity of these genes (PPI enrichment p = 1.15e−05) ( Fig. 8I ).

We repeated this analysis removing the 19 known ASD/ID genes ( Supplementary Data 1 ) and observed a reduced but still highly significant signal ( P =1.17 × 10 −5 ) corresponding to an odds ratio of 4.1 (95% CI=2.2–7.0).

Moreover, employing k-values from 2020 and 2021 to establish classification functions and 2022 k-values for cross-validation to predict sample classification, a highly significant discrimination ( p = 0.000012) was observed among EVOOs stored at different temperatures.

Interestingly, when assessing whether the sex of an individual contributes to its methylation level, we found a highly significant sex effect at VM-IAP Rnf157 whereby males are more likely to exhibit higher methylation levels than females (p = 1.20e−5; q = 2.16e−4; Figures 6 G, S5 B, and S5C).

The 4-GES again predicted OS in a highly significant manner (adjusted p = 1.2 * 10 −05 and adjusted p = 5.6 * 10 −05 for cohorts 1 and 2, respectively; Fig. 2A,B ).

Combining data from neuropathological and clinical replication cohorts revealed highly significant associations of all ten GAB2 variants (9.7×10 −11 <p<1.2×10 −5 ) with LOAD.

[ 34 ] described significantly lower levels of agalactosylated structures for IgG of the fetus (mean value of 13.1 %) as compared to maternal IgG (mean value of 16.7 %; difference of 3.6 % is statistically highly significant; p = 0.000012; see Table 4 ).

Assuming the population origin on the coast between NQLD and CQLD, we considered Mackay, the first port of entry for European settlers on the Australian tropical coastlands [ 38 ], and found a highly significant positive correlation between β st and distance from Mackay ( r = 0.91, p = 1.2 × 10 −5 , Figure 2 C).

Still, re-analysis of the correlation between BAT volume and LysoPC-acyl C16:1 in discovery population showed that the correlation was still highly significant (p = 1.2 × 10 −5 ) when the BAT negative subject is included.