“highly significant”

As expected, we observe stronger average absolute correlation in the ISO-treated cohort ( R = 0.174 vs 0.111), and that while the control cohort’s correlations of the adrenergic signalling pathways with Serpina3n were not significantly higher than expected ( p = 0.728), the correlation of Serpina3n expression with the ISO cohort was highly significant ( p = 4.9 × 10 −5 ).

Myc knock-down had a highly significant effect on the extent of glial dedifferention (one-way ANOVA, F (3,13)=18.99, p =4.94×10 −5 ).

We found that the pair of chromosomes 4 and 5 show highly significant nonindependence across the set of crosses (Bonferroni adj., p = 5 × 10 −5 , permutation test, Figure 5B ), suggesting a genetic interaction between this specific pair of chromosomes.

-0.15 SD, respectively and the difference was highly significant (t(52) = 5.25, p = 0.00005).

The difference between the survival curves for of the high and low risk phenotypes is highly significant (p < 0.00005).

The trained birds' preference for the Dreadnought Grey disc was statistically highly significant (P<0.00005, using the binomial statistics described in “ Methods ”).

BALB/c mice vaccinated with 20 μg of SLA plus 50 μg of CpG ODN showed a highly significant (P<5×10 −5 ) reduction in swelling compared to SLA-vaccinated mice and enhanced survival compared to unvaccinated mice.

To exclude the possibility that an individual SNP behaved aberrantly in the analysis, we also sequenced the SNP 6651T > A, yielding similar findings, and both SNP assays combined, the observation of allelic imbalance in cases versus controls was highly significant ( p < 0.00005 by t test).

A highly significant ( p value < 0.00005) likelihood ratio test compared to a standard logistic model supported that the mixed-effects model was better fit for our data.

Moreover, we compute the Pearson correlation coefficient (r) and mean absolute error (MAE) for cellularity estimations, and the results show that the estimated cellularity of CLImAT-HET has a highly significant positive correlation (r > 0.99, p -value < 5 × 10 −5 , MAE < = 0.02) with the underlying cellularity across all simulated samples (Fig. 3a , b and c ), which demonstrates CLImAT-HET’s ability to precisely recover clonal architecture.

We then plotted the observed responses to random textures against the predicted responses, the resulting correlation was positive and highly significant ( r = 0.75, P < 0.00005; Fig. 6 B ).

The difference in the distributions of the number of viable daughter cells per mother cell is statistically highly significant with a p -value < 0.00005 (two-sample t -test).

Volumetry could demonstrate a highly significant ( p = 0.00005) volume increase, while the intervention led to a significant ( p = 0.0076) volume decrease during the day.

The correlation between duration of illness and grey matter volume across all networks (uncorrected for TIV and age) showed a highly significant correlation (r = −0.37, p < 0.00005) which was no longer significant after correcting for age and TIV (r = 0.06, p = 0.56).

Functional enrichment of the 606 putative hypoxia genes revealed highly significant functional groups ( p < .00005) related to oxygen sensing and hypoxia (GO:0036293, GO:0070482, GO:0001666, GO:1901700) and energy management (GO:0015979, GO:0019684, GO:0009765, GO:0009055, and GO:0004022).

In addition, to mitigate potential impacts of small expected counts (e.g., expected values < 5 for TPS-c) on the chi-square approximation, a permutation test (20,000 permutations) was performed and also yielded a highly significant result ( p ≈ 5.0 × 10 −5 ), further supporting that the distribution of core/non-core status varies significantly among subfamilies.

In both years, the differences among accessions were highly significant ( p = 0.00005 and p = 0.00003, respectively).

The blocking test showed that the pre-treatment of SK-RC-52 renal carcinoma cells with a large excess of unlabeled Ec1 resulted in a highly significant (P<0.00005) reduction in binding for both radiolabeled DARPins ( Fig. 1 ).

We identified highly significant correlation differences between incident CAD cases and controls ( p < 5 × 10 –5 ); eGFR correlated more strongly with 3-hydroxyisobutyrate ( r case-to-control = 0.29), citrate ( r case-to-control = 0.42), and glycine ( r case-to-control = 0.35), while 4-deoxyerythronic acid correlated less strongly with triglycerides ( r case-to-control = −0.35), and hypoxanthine with creatinine ( r case-to-control = −0.30) in individuals with incident CAD.

Using a highly significant P value cutoff ( P < 0.00005), we identified 12 proteins that exhibit differential expression between these OA subsets (Figure 3 ).

The results presented in Table 3 showed a highly significant ( p value = 0.00005, detection limit of the method being approximately 1 log CFU, CI-95%, 1.85, 2.77) log reduction (2.31) in microbial load after wiping the meat surface with the developed DW (count before treatment—5.48 log CFU/cm 2 ; after treatment—3.17 CFU/cm 2 ).

A highly significant increase in apoptosis was observed in infected IFX‐treated mice compared to the anti‐mouse TNF‐α‐treated group ( P = 5 × 10 −5 ), suggesting that IFX mediated its effect on cell survival independently of TNF‐α, a conclusion reinforced by the similar effect of human IgG.

While there was no significant effect of blindsight status (positive or negative; F = 2.6, p = 0.13), there was a highly significant effect of lesion side (ipsilateral or contralateral; F = 35.7; p < 0.00005) and interaction, suggesting a differential effect of the lesion in the two patient groups (F = 5.1; p = 0.04).

When the same analysis was run three times, comparing the intention-offloading/nonoffloading task with the other tasks one by one, the intention-offloading/nonoffloading predictor was always highly significant, t (990) > 4.0, p < .00005, but none of the other three was, t (990) < 1.35, p > .17.

Taking a total of a 20-week interval (as transmission events between hospital cases with an onset further than 20 weeks apart is assumed to be unlikely), the model revealed a highly significant Box-Pierce Q-statistic (X 2 = 54.59, degrees of freedom (df) = 20, p = 0.00005), indicating non-independence.