“highly significant”

wound infection biofilm antimicrobial antiseptic hypochlorous acid human plasma biofilm model wound irrigation chronic wound internal grant program of the Faculty of Health at Witten/Herdecke University, Germany IFF2018-61 German “Initiative Chronische Wunde e.V.” (ICW e.V.) Both reference substances, OCT/PE and PHMB-based irrigation solution, achieved a highly significant reduction of P. aeruginosa (4.77 ± 1.41 and 5.25 ± 0.93 log 10 steps, respectively; p < 0.0001), S. aureus (6.18 ± 0.00 and 4.82 ± 1.36 log 10 steps; p < 0.0001), and MRSA (both 6.18 ± 0.00 log 10 steps; p < 0.0001) within 30 min of exposure ( Figures 2A – C ).

One‐way analysis of variance (ANOVA) analysis demonstrated that substrates had a highly significant effect on regimens 1, 2, 3, and 4 ( p = .0001).

The results of the main analysis using an adjusted model, controlling for multiple covariates, were however highly significant (χ 2 = 1317·65, df = 7, p < 0·0001; Table 2 ); consistent with our hypothesis, the 22q11.2 deletion was a significant independent predictor of risk of T2D (OR=2·44, 95% CI = 1·39–4·31).

These effects were highly significant ( P < 0.0001) throughout all feeding phases of the trial.

Most importantly, we found, in addition, a highly significant interaction [ F (2, 126) = 8.03, p < 0.0001, η 2 = 0.12] between both factors (see Figure 3B ).

The ANOVA analysis showed highly significant differences ( p < 0.0001) in the antioxidant activity between H and ZnO NP-loaded formulations, except between HZ 5 and HZ 7.5, where no significant differences were observed.

These differences between habitat types were highly significant (H 5df = 27.91, p < 0.0001). 3.3.

The between-subjects effect of treatment group was highly significant ( p < 0.0001 at all time points), reflecting the consistently higher amylase levels in the NNRTI/PI group compared to the INSTI group throughout the entire observation period.

The results showed a highly significant correlation between meniscal injuries on MRI and intraoperative findings ( p < 0.0001).

The percentage of cells invaded by one, two, three, four, or more than four foundress mites, as a function of infestation level, was estimated by five highly significant ( p < 0.0001) second-degree polynomial regression equations.

The increases from month 4 to month 12 were highly significant for each group (p = 0.0001).

Geographical distribution of folate-mediated one-carbon metabolism pathway alleles and genotypes showing continental variation and intra-population differences in Mexican Mestizos In contrast to the additional four out of the eight variants analyzed, MTRR A66G, MTHFR C677T, A1298AC and MTHFD1 G1958A showed a gradient in the frequency between MEX groups and highly significant differences between AMI and EUR groups ( P values <10 −4 ).

Diagnostic potential of miR-363 According to ROC curve analysis, miR-363 covered a highly significant ( P <0.0001) area in both PCa tissue (0.969; sensitivity: 85%; specificity 100%) as well as serum (0.988; sensitivity: 97.5%; specificity: 87.5%) ( Fig. 3A & B).

Furthermore, the compound induced a highly significant (P < 0.0001) antiproliferative effect at 72 vs. 96h exposure period (concentration range 31.25–250 μM in MDA-MB-231 and 15.62–125 μM in MDA-MB-468 cell line) as indicated by the significant reduction in the IC 50 values, in particular for MDA-MB-468 cells.

We obtained a highly significant area under curve (AUC) which gave a good separation between Control and ALL (sensitivity is 93.22% and specificity is 93.33%, P <0.0001) ( Figure 1 B and Table 2 ).

This difference was statistically highly significant ( P < 0001) [ Table 1 ].

Critically, the main effect of Emotion type was highly significant [ F 1 (1,59) = 200.95, p < 0.0001, η 2 = 0.23; F 2 (1,18) = 8.84, p < 0.009, η 2 = 0.27], as putatively basic emotions ( M = 5.72) were rated higher than non-basic emotions ( M = 4.61).

Interaction of any two of the three tested variables and the combined three variables was highly significant ( P < 0.0001, Mixed models).

Results A mean neutralization titer 50% of 230 (range, <8‐1765) was seen for the 100 convalescent plasma units, with highly significant ( P < .0001) yet quantitatively limited (R 2 = 0.2830) correlation with results of the ELISA.

VE/VO 2 showed a highly significant difference during the first 20 s of recovery ( p = 0.0001, r = 0.834, 95% CI: −5.05 to −3.06), whereas no significant differences were observed during the subsequent 20–40 s and 40–60 s intervals ( p > 0.05).

The level of SC5b-9 increased significantly at T2 in the normothermic group, and the differences between T1 and T2 and between T1 and T3 were both highly significant (P<0.0001, Fig 2B ).

Interestingly, our formulation was capable of inducing a 1.65-fold higher immune response in rabbits than in cattle (i.e., a 65% increase); this difference was highly significant (p<0.0001; Figure-3a and b ).

The results showed highly significant main effects (all p < 0.0001, Supplementary Material Table S4 ) regarding nebulizer type, placement position, and artificial airway type.

In addition, when comparing delta values of both groups, we observed in MTZ-treated patients a highly significant reduction (i.e., clinical improvement) for both RCSS ( p < 0.0001, Mann-Whitney; Fig. 4 b) and MBAS values ( p < 0.0001, Mann-Whitney; Fig. 4 d) with respect to the untreated group.

The level of significance was evaluated using P-values, with the following classifications: P≥0.05 denotes non-significant results, P≤0.05 denotes significant results, P≤ 0.01 denotes highly significant results, and P≤0.0001 denotes very highly significant results.