“highly significant”

While the improvement within the SOD group was highly significant (p < 0.0001), the between-group difference (~11%) did not reach statistical significance (p = 0.089), possibly due to limited power and smaller-than-anticipated effect size [ 7 ].

There was a highly significant statistical interaction between age and residence after adjusting for time from initial diagnosis of CDI to the second episode ( P < 0.0001) ( Table 3 ).

There was a highly significant negative correlation between the changes in PINP and BMD in lumbar spine and femoral neck from baseline to 12 months in all patients (r(s) = -0.68, P < 0.0001, and -0.45, P < 0.0001, respectively), and in pre- and post-menopausal patients separately.

Despite the different set of antibodies employed and potential batch effects, we observed a highly significant correlation between results obtained with the two methodologies (p < 0.0001, r 2 = 0.3).

Specifically, for thermal pain measurements, both the MA and AR manipulations showed highly significant increases in AAT compared to AII (both P < 0.0001).

The difference in weight between the prototype and control is highly significant (unpaired t-test, p-value < 0.0001) ( Fig 3A and 3B and S1 Table ).

We found a highly significant correlation for the oligomers generated from both HypF-N (r = 0.93, P < 0.0001) and Aβ 42 (r = 0.95, P < 0.0001).

Temperature effects on mycelial growth of different Fusarium species According to ANOVA, the average effects of different temperatures on fungal radial growth of Fusarium species were highly significant at P < 0 . 0001 .

Difference in slopes between the two groups was highly significant ( P < 0.0001).

When the same cohort was stratified by CAB, the results showed a higher difference in DMFS (10.84%) between the low‐ and high‐risk categories with a highly significant P ‐value of <0.0001 (Figure 2 A) suggesting that CAB is a better prognostic predictor in comparison to node status.

A two‐way ANOVA showed highly significant effects of treatment [F(1,59) = 126.4, p < 0.0001], gene [F(5,59) = 75.40, p < 0.0001], and their interaction [F(5,59) = 74.37, p < 0.0001].

However, at later time points the curves deviated from each other ( Figure 6 B) and highly significant differences (Wilcoxon test, p < 0.0001) were observed between the two genotypes.

In terms of soil organic matter content, Wutai County had a significantly higher level (35.25 ± 4.20) compared to Pingshun County (26.65 ± 2.14), and this difference was statistically highly significant ( P < 0.0001).

Notably, LGALS9 and SIRPA showed highly significant differences between the high- and low-risk groups (P<0.0001) ( Figure 6B ).

As displayed in Table 1 , results revealed that the fitted model was highly significant ( p < 0.0001), indicating that it could effectively explain the variation in the yields of YKP ( Wu et al., 2021 , Wu et al., 2022 ).

A meta-analysis based mainly on the findings of six studies pertaining to treatment with clozapine supported a significant overall beneficial effect on suicidal behavior, with a highly significant ( p < 0.0001), 3.3-fold [CI: 1.7–5.7] lower pooled risk of suicidal behaviors with clozapine compared to alternative treatments [ 41 ].

The difference in survival between the two groups was highly significant (HR: 7.8, 95% CI: 4.0–15.2; p<0.0001) ( Fig. 2 ).

The ANOVA results ( Table 6 ) confirmed that the quadratic model for EPS production was highly significant ( p < 0.0001) with an F value of 37.21.

Figures 1 and 2 illustrate the tumor budding categories. Tumor budding and advanced tumor stage, tumor invasion, vascular invasion, perineural invasion, and desmoplasia were significantly associated. The link between regional lymph node metastases and tumor budding was highly significant (P=0001).

Overall there was a highly significant difference between the two groups of donors as determined by two‐way ANOVA ( p < 0.0001) (Fig. 3 ).

Statistical analysis using one-way ANOVA confirmed that the differences in biofilm formation between treated and untreated groups were highly significant ( p < 0.0001 for Δ agrA and MRSA).

The results clearly demonstrate highly significant CD4 + and CD8 + T cell allogeneic immunization in partners practising unprotected homosexual (p<0.0001 and p = 0.001) or heterosexual (p = 0.001 and p<0.0001) intercourse, respectively.

The mean value of GPx in the present study was 16.46 U/g Hb before supplementation and 4.53 U/g Hb after, and paired t -test showed the differences in GPx, GSHt and GSH/GSSG ratio to be statistically highly significant ( p <0.0001).

In particular, Spot, Brown Spot and Wrinkle Percentiles showed highly significant improvements at all follow-up points compared to baseline ( p < 0.0001); similarly, UV spot, Pore and Texture indexes demonstrated marked improvement starting in the first month ( p < 0.01) and sustained through the third month ( p < 0.0001).

Among the two hiPSC lines, the highly significant ( P < 0.0001, paired t test with Bonferroni correction) reductions in methylation observed for the donor L1 during hiPSC derivation (25.0% on average) far exceeded that seen for the lineage progenitor (12.5%) and L1-Ta subfamily (2.9%) ( Fig. 5C and 6B ).