“highly significant”

the threshold of 0.44 is highly significant (p-value = 2.3 × 10 -4 ).

The bidirectional relationship between CBF and CMRO 2 was highly significant ( p = 0.00023), and both contributed to the changes in OEF.

Water regime under salt stress and QuitoMax application The differences in the water potentials of the varieties in the different treatments were highly significant [F = 108.5; p = 0.00023, F = 112.46; p = 0.000321 for Amalia and Claudia, respectively (Fig. 2 a and b)], and a similar response was found for the osmotic potential (F = 207.32; p = 0.00461, F = 201.31; p = 0.00117 for Amalia and Claudia, respectively).

The difference was already highly significant at 1 h (*** p = 0.000232), and became even more pronounced at 24 h (**** p = 0.000005).

The corresponding OPLS-DA model was highly significant: R 2 X = 0.464, R 2 Y = 0.918, Q 2 = 0.567 and p = 0.00024 ( Figure 4 B).

The differences were highly significant with the Kruskal-Wallis test (p = 0.00024).

The ANOVA of the Plackett-Burman design demonstrated that the model was highly significant as was evident from the Fisher’s F -test (51.910) with a very low probability value [ P- value = 0.00024] and the t -Stat of 493.355.

Statistical testing of the overlap among the peaks of these datasets and our Satb2 ChIP-seq data revealed highly significant enrichment (adjusted p<0.00024) of active chromatin states (H4K16ac, H3K27ac, H3K4me1, H3K4me2, and H3K4me3 peaks) and PolII peaks at Satb2-bound promoters ( Figure 5C , Figure 5—figure supplement 2A ).

Once both of these classes of tumors were removed, the correlation between the two estimates of lifetime mutation accumulation in the remaining 28 tumor types was highly significant ( P = .00024, r=0.64).

Out of the 24 highly significant metabolites 14 (58%) could be confirmed at the high (p < 0.00024) and 19 (79%) at the normal (p < 0.05) significance level (figure 4 ).

There was a highly significant correlation (r = 0.9883; p = 0.00025) between age-stratified mortality rates and IL-6 levels from previously published data on healthy individuals.

The Chao1 index showed highly significant differences among groups ( p = 0.00025), with the HFD group exhibiting markedly reduced microbial richness compared with the ND group.

All four axes remained highly significant after conservative cross-family correction (all Holm-adjusted P < 2.5 × 10 -4 ), confirming that the convergent multi-omics signature associated with elevated Rad-Score — encompassing ferroptosis activation, effector immune infiltration, genomic instability, and spatially organized chemokine networks — is robust and independent of false-positive inflation across omics families.

We find highly significant differences between groups in motor noise ( F = 8.7, p = 2.5e−4), driven by enhanced motor noise in the relatively ‘Low’ subtype compared to the relatively ‘High’ subtype ( t = − 3.2, p = 0.002, Cohen’s d = 0.77) and compared to TD children ( t = − 4.1, p = 1.33e−4, Cohen’s d = 0.85).

The differences were highly significant (p < 0.00025).

Importantly, while the BV/TV values of sham-operated wild-type and PLCγ2 −/− animals were statistically highly significant ( P = 0·00025), there was no significant difference between the two genotypes after the ovariectomy procedure ( P = 0·25; n = 7 (wild type) vs. 4 (PLCγ2 −/− )).

The yield model was highly significant with a very low p=0.00025.

Permutation tests showed that the effect of feeding treatment was highly significant for population growth rate ( p < 0.00025 ) and stable population structure ( p = 0.0012 ; Figure S3 and Table S1 ).

Results were statistically highly significant ( P = 0.000251, Spearman Coefficient: 0.91815).

A robust negative correlation to IC 50 ( r = −0.504) was exhibited by the Number of Hydrogen Bond Donors (NumHDonors), accompanied by a highly significant p -value ( p = 2.56e-04), which was indicative of an association between a higher count of hydrogen bond donors and enhanced compound activity.

In contrast to TMX(-) studies, here we observed a highly significant interaction between Cre-ER and Lox-Stop (p=2.59E-4), which suggested that SynGAP re-expression altered activity suppression levels.

Kaplan–Meier analysis revealed a striking survival advantage for the high methylation group, with a highly significant difference in OS (log-rank p = 0.00026) (Fig. 2 d).

For example, there is a highly significant correlation between expORChID2 values and X-ray-derived minor groove widths for the Ubx-Exd heterodimer DNA binding site, because P = 0.00026 falls below a confidence level of 0.001.

One comethylation module (Bisque 4) showed a highly significant negative correlation between sample eigennode values and ASD diagnosis ( P = 2.6E−4).

However, when we performed mediation analysis, conditioning on the expression of TOP2B , the association between CX-5461 IC 50 and MYCN expression was lost ( P = 0.8), but TOP2B remained highly significant ( P = 2.7 × 10 −4 ), suggesting that the association between MYCN and CX-5461 IC 50 was mediated through MYCN ’s effect on TOP2B expression.