“highly significant”

Consequently, there was a highly significant underrepresentation of such differentiation profiles such as the VERHAAK_GLIOBLASTOMA_PRONEURAL signature in the clones (nominal P = 0.000446; Fig. 4C ), along with an enrichment of mesenchymal gene sets such as HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION (nominal P = 0.000227; Fig. 4D ).

Half of the 44 individuals in group 2 exhibited SBS18 in their CRC, representing a highly significant increase over group 3 (2.7-fold odds ratio, P = 4.48 × 10 −4 ; Table 1 , Fig. 4 , Supplementary Tables 1 and 2 ).

A highly significant global association was detected in female participants (global P = 4.5×10 -4 ), whereas no evidence of a comparable association was observed in males.

After FDR adjustment, exon 6 showed a highly significant enrichment of mutations in BC ( p = 0.00045), whereas no significant difference between exons 5 and 6 was observed in OCC ( p = 1.000) or PC ( p = 0.384).

We also found that the inhibition of PAI-1 activity with a small molecule PAI-1 inhibitor TM5275 almost completely restored the p53 protein degradation rate that was inhibited by bleomycin in A549 cells (the time-dependent changes in the amounts of p53 protein between bleomycin + TM5275 and bleomycin + solvent were highly significant, p = 0.00046; those between bleomycin + TM5275 and saline + TM5275 were not significant, p = 0.626; those between bleomycin +TM5275 and saline + solvent were not significant, p = 0.945) ( Figure 3 D,E).

4 × 10 −4 ) and highly significant (median predictor cross-validation P = 4.6 × 10 −4 ), consistent with previous findings that low average heritability of gene expression can be compensated for by sample size sufficient to produce reliable genetic predictors ( Supplementary Table 7 ).

In fact, when patients treated in first and second line of therapy were taken together this association was highly significant (p=4.6 x 10 –4 , n=64).

This confirmed a highly significant association between day 21 large clone count and six-month outcome, with responders having on average 5.7 more large clones on day 21 (95% CI: 2.6 - 8.87, P=4.8×10 -4 , Supplementary Figure 1 ).

As shown in Figure 4A , 10 min of retinoschisin treatment slightly reduced Src phosphorylation (86.8 ± 2.9%) compared with control treatment but with a statistically highly significant difference between retinoschisin and control treatment ( p = 4.9 × 10 -4 ).

The total effect of NR (Model 2) was highly significant ( t test, p < 0.0005) with a standard regression coefficient (β) of 0.63, indicating a large effect.

Fitting a mixed-effects model with Šídák’s post-hoc test comparing the time to diagnosis of radiologists and neurosurgeons, a highly significant effect was discovered in patient’s heterogeneity (p = 0.0005), but not in the training of the rater (p = 0.74).

Observable differences are highly significant; performing one-sided Mann-Whitney U tests (with the alternative hypothesis c treated > c untreated ) leads to the rejection of the null-hypothesis (p < 5 x 10 −4 ) for all metabolites.

The differences were highly significant (χ 2 (2) = 23.42, p < 0.0005).

Similarly, post-BCG vaccination, there was a highly significant increase in BCG-specific CD4 + and CD8 + Ki67 + IFN-γ + , TNF-α + , IL-2 + and IL-17 + T cells, P < 0 .0005 ( P = 0 .003 for CD8 + IL-17 + T cells).

Linear regression analysis showed a highly significant relation of wound drainage with the duration of antibiotic treatment (p<0.0005, R 2 =97%) and the length of hospital stay (p<0.0005, R 2 =74%).

Difference between the mean values of the WFs for the four shortest and four longest ICIs proved to be highly significant [ t (9) = 7.21, p < 0.0005].

GRP78 attracted our attention due to its high protein amount found in sparsely growing cells, and its highly significant difference in the two growth patterns (SW480: 3.3-fold, p = 0.0005, Figure 1B a, b, c ; HCT116: 2-fold, p = 0.0005, Figure 1B d, e, f ; single analyzed 2-DE areas are shown in Figure S1B ).

The result of the Friedman’s test was highly significant ( P =0.0005).

This huge change is both practically important and highly significant statistically ( p < 0.0005 and Cohen's d for the change is 1.07, a large effect size).

Fasting PG day0 demonstrated a highly significant, batch-adjusted correlation with A1C day0 ( n = 43, r = 0.65, P < 0.0005, and 95% CI 0.48–0.81).

Results obtained from PLS-DA ( Figure 2A ) revealed that metabolic features formed distinct clusters (15 cells in each group), and this difference was highly significant ( p = 5 × 10 -4 ; permutation test in Metaboanalyst 3.0).

In comparison, NP‐UAEC linear correlations between AUC and V m change were more highly significant ( P < 0.0005) and more predictive in showing greater hyperpolarization as AUC increased for both the initial peak and sustained [Ca2+]i phases.

These differences were highly significant (p<0.0005) ( Figure 2a ).

Differences were considered significant with a P-value below 0.05 (p < 0.05, *), highly significant (p ≤ 0.005, **) and extremely significant (p ≤ 0.0005, ***).

bacteriovorus (80%) similar to controls (100%), but, contrarily, the 93.5% drop in its relative abundance was highly significant ( P <0.0005) ( Figure 2 ).