“highly significant”

When GG haplotypes (Hap5-8) were compared with AA haplotypes (Hap1-4), a highly significant difference in 5-FTHF level was observed (P = 3.58 × 10 -29 , n = 193) ( Figure 5 ).

Moreover, the sample distributions in the X-axis and Y-axis show highly significant differences (Wilcoxon’s test P -value = 4.1 × 10 -29 ).

11C ) and show a highly significant correlation ( R = 0.67, p < 5e−29, for diverse environments.

Most results were highly significant ( p < 6 × 10 −29 ), except for MG ( p < 7 × 10 −3 ), which had the smallest sample size of 234 cases, and PsA ( p < 3 × 10 −6 ), in which the discovery GWAS had only 1430 cases.

The association between the two classifications was found to be highly significant (χ 2 = 138.3, p = 6.4 × 10 −29 ).

In two-way (genotype and environment) ANOVA, the genotypic variations for the four index traits were highly significant ( P -value = 8.57e-29 ~ 3.62e-11) (Table S3 ), indicating the feasibility of conducting GWAS for the four index traits.

When we performed a gene-set enrichment analysis of these 1,341 genes using the Database for Annotation, Visualization and Integrated Discovery 20 , we found highly significant enrichment of ‘SP_PIR_KEYWORDS: alternative splicing' (Benjamini-corrected P =8.6 × 10 −29 ) and ‘UP_SEQ_FEATURE: splice variants' (Benjamini-corrected P =1.1 × 10 28 ), which denote genes with known splicing isoforms ( Supplementary Data 2 ).

This genotyping revealed that in 56 of 57 cases, orange and mosaic individuals were homozygous for one allele (hereafter o ) at the SPR locus, whereas yellow and white individuals, with one exception, were either heterozygous ( n = 41) or homozygous ( n = 16) for the alternative allele (hereafter O ): a highly significant association (recessive model, P = 9.3 × 10 −29 ).

As anticipated from the above reported changes in group mean SRT, a multiway ANOVA of left and right median SRT values, with group and task as factors, revealed a highly significant effect of task (F(2, 110) = 129, p < 10 –28 ).

The resulting Manhattan plot ( Figure 5B ) identified several highly significant metabolic hubs: 3.6.1 Stress-induced lipid amide accumulation The tentative lipid amide (m/z 338.33) was the most significant feature ( p < 10 -28 ), showing prominent accumulation in T3 and T4 samples as a marker for biotic stress. 3.6.2 Phenolic partitioning and correlation with lipid derivatives Quantitative analysis showed that Benzoic acid (GC_BA-TMS) levels were significantly higher in T2 compared to all other treatments.

Pathways showing highly significant results include the MAPK signalling pathway ( p -value = 1.29E-28), the FoxO signalling pathway ( p -value = 8.09E-19), the HIF-1 signalling pathway ( p -value = 9.65E-19), the PI3K-Akt signalling pathway ( p -value = 1.09E-18), and the insulin signalling pathway ( p -value = 2.87E-16).

8 , 9 The strongest and most highly significant associations have been reported with early-onset, persistent eczema 10 , 11 (odds ratio 5·6, 95% confidence interval 4·1–7·8, P = 1·3 × 10 −28 ) and asthma occurring in individuals with atopic eczema 12 – 14 (odds ratio 3·49, 95% confidence interval 2·00–6·08, P = 1·0 × 10 −5 ).

The rs334 SNP, when directly genotyped, was highly significant ( P = 1.3 × 10 −28 ), whilst the best marker in the GWAS SNPs ( P = 3.9 × 10 −7 ) did not reach genome-wide significance.

Using the complete variant dataset, we found a highly significant difference in the distribution of distances between intra-individual and inter-individual samples (Wilcoxon test, HaplotypeCaller: p = 1.31 × 10 –28 , Mutect2: p = 1.51 × 10 –28 ) ( Figure 5B ).

Comparison of Models 1 ( α = β 1 = β 2 = 0) and 2 ( α = 0) in Table 2 reveals a highly significant offspring SE allelic effect on RA risk ( χ 2 2 = 128.1, p = 1.5 × 10 -28 ).

The scores only explained 3% of the variance in schizophrenia case-control status, but the large sample sizes ensured that this was highly significant (up to P = 2 × 10 −28 ).

Instead, we observe that an increase in STAT3 binding is correlated with an increase in expression in most of these pairs (83%, n = 686), an association that is highly significant at P = 2.3 × 10 −28 ( Table 4 ).

The type of incubation fluid exhibits a highly significant impact on the sorption ability, as indicated by an exceptionally low p -value ( p = 2.45 × 10 −28 ), suggesting that the fluid type strongly influences the swelling behavior of hydrogels.

However, although the difference in terms of percent variation explained in RBC by SSCCA vs SSMCCA methylomics CV1 is highly significant (p-value = 3E-28), the absolute difference (4.27E-8 percent variance explained) is tiny, suggesting the difference between the performance of two methods is negligible.

An Amino Acid Permease gene, CsAAP2A (gene ID: Csa4M573860), was selected as a promising candidate gene based on the finding that this gene was down‐regulated by a factor of 100 in NIL DM4.1.3 compared to HS279, which was highly significant (Benjamini–Hochberg corrected p value = 3.1 × 10 −28 ). 2.2 Lack of CsAAP2A expression is due to the insertion of a CUMULE transposon To investigate the reason why CsAAP2A was very poorly expressed in NIL DM4.1.3, we resequenced the whole genomes of genotype NIL DM4.1 (an NIL with an introgression spanning subQTL DM4.1.1, DM4.1.2, and DM4.1.3) as well as susceptible parent HS279.

We found highly significant negative genetic correlations between sociability and ASDs ( r g = −0.27, p = 3.6e−28), MDD ( r g = −0.67, p = 4.5e−249), and SCZ ( r g = −0.15, p = 7.5e−23).

Sex-related tissue specificity One network specific to histologically normal tissue (Normal: lavenderblush3) featured a highly significant relationship with biological sex (bicor 0.82 P = 3.72 × 10 –28 , n Obs = 113, see Supplementary Fig.

As shown in Table 2 , the DEGs from the Rat in vitro model (Rat-DEGs) exhibited a high correlation with those from the Human in vitro model (Human-DEGs), sharing a highly significant gene overlap ( P = 4.02E-28).

rs13038305 in Relation to Cystatin C At baseline each copy of the major allele of rs13038305 was associated with a highly significant approximately 0.30 standard deviation (SD) higher plasma concentration of cystatin C both in model 1 (β = 0.33, p = 4.2E-28) and model 2 (β = 0.33, p = 1.7E-29).

In PRAD, the correlation between DRD1 expression and immune purity was highly significant (correlation = 0.502, p = 4.93e−28), and a similar pattern was noted for immune cells (Fig. 7 c) .