“highly significant”

Although the MHC association is highly significant in both OLP and non-OLP, it is dramatically stronger in non-OLP ( p = 5.6 × 10 −28 for difference in effect), and the association in non-OLP near CLEC16A does not even reach nominal significance in OLP.

Results Broad depression phenotype with self-reported MDD The genetic correlation ( r g ± SE) between the broad depression phenotype and self-reported MDD in the 23andMe data, calculated using the LD Score regression method, was 0.79 ± 0.07 and highly significant ( p = 5.70 × 10 –28 ).

Expectedly, a highly significant naming deficit became obvious for LIP in comparison to HIP (p=7.0×10 -28 ) and healthy controls (p=9.1×10 -29 ) (Figure 2 C).

In the offspring cohort, the spouse correlations were lower but still highly significant for PC1 (r = 0.38, P = 7x10 -28 ) and for PC2 (r = 0.45, P = 2x10 -39 ).

In general a highly significant correlation between miR-122 expression levels and target gene perturbation was observed in HCC samples ( p = 8.1 × 10 −28 ).

The results with GENECONV (Table 1 ) were highly significant (p values < 10 -27 -10 -66 ) between the paralogues of the same species in groups 1, 2 and 3 providing evidence of gene conversion between ancestral sequences of paralogues.

However, only the primary angiosarcoma specimen, AS1, exhibited a prominent and highly significant ( P <10 −27 ) expression transition ( Figure 2A ), with the predicted breakpoint corresponding to known rearrangements of ROS1 in other malignancies.

Above all, in all GO analyses there was a highly significant enrichment in the term ‘testis’ for the tissue category (p < 10 −27 ), indicating that most DE coding genes that are co-expressed with lncRNAs along spermatogenesis are testis-specific.

The top five ranked interlinked pathways (Supporting Information Table S5 ) and the three Gene ontology (GO) molecular function terms (Supporting Information Table S6 ) are highly significant ( p ≤10 −27 ) with respect to genes differentially expressed after RPL19 knockdown.

This 14-fold increase of gene numbers regulated by HPV E7 in addition to E6 among pocket protein target genes is highly significant ( P < 10 −27 ) and thus substantiates the model that p53 can directly activate its target genes while p53-dependent repression largely occurs via the p53-p21-DREAM/RB pathway.

Inception-v4 consistently ranked last, with an accuracy of 87.42% and an AUC of 94.24%, and exhibited highly significant disadvantages compared with all other models ( p < 10 − 27).

The overlap between our gene list and previously published data [ 29 ] was highly significant (35% overlap, hyper-geometric test p < 10 −27 ), and dissimilarities were likely due to the different ages of flies in the two studies (40 days in the current study as opposed to 10 days in [ 29 ]) as previously reported [ 30 ].

However, stratification by isoform into LMW (at least one isoform with 10–22 KIV repeats) and HMW (only isoforms with >22 KIV repeats) carriers, revealed a highly significant decreasing effect of rs41272110 in LMW carriers (β = –24.28, p = 1.05e-27), which was not seen in HMW carriers, where it presented rather a small but significant Lp(a)-increasing effect (β = +1.69, p = 6.13e-07).

Differences between the two groups were highly significant (p = 1.5×10 −27 ).

The differences in proportions with ≥ 1 APOE ε4 allele were highly significant ( p = 1.5 × 10 −27 ).

This 4.4% decrease in lifetime is highly significant (P = 1.6 × 10 −27 ).

The discrimination capacity of the model was high (AUC = 0.811) and highly significant ( p = 1.782 × 10 –27 ).

The results of this analysis, following removal of outliers, revealed a highly significant effect of the mutation type (specifically splice-site mutations) on the number of CALs, both with 1 to 5 CALs ( p = 1.8 × 10 −27 ) and 6 to 99 CALs ( p = 8.5 × 10 −43 ), as well as for skin freckling ( p = 0.028) and neoplasms ( p = 0.006).

Association analysis revealed a highly significant association between rs13292899 and NSCL/P risk ( p = 1.85 × 10 −27 ) [ 73 ].

These analyses also further revealed highly significant associations for the MRPS18C isoform uc003hor ( P = 1.94x10 -27 and r 2 = 0.143) (Figure 6E ).

In addition, we identified highly significant missense variants (<5 × 10 −15 ) within the FLG gene (rs558269137, beta = −0.222, p = 1.96 × 10 −27 ) and the KRT1 gene (rs14024, beta = −0.030, p = 3.95 × 10 −15 ).

The samples clustered into two distinct and well-separated classes, and evaluation of the model showed that it was highly significant ( p = 2.3E −27 permutations p = <0.001).

We detected approximately 15.000 transcripts in the ventricles and surprisingly, within the TAD only Scn5a expression was highly significant downregulated ( P = 3.75e-27) in RE6-9 +/− mice (Fig. 4c–f ).

Two-way ANOVA revealed a highly significant difference between the two cell lines ( p = 4.68 × 10−27), indicating a strong overall effect of cell type on the outcome (partial η2 = 0.484).

Gene ontology term analysis for the training response also revealed a highly significant over-representation of neurological processes ( Neurological system process: P = 4 .85 × 10 −27 , Cognition: P = 1.92 × 10 −22 , Sensory perception: P = 4.21 × 10 −21 ) and the extracellular region ( Extracellular region: P = 1.40 × 10 −10 ).