“highly significant”

A contingency table analysis revealed a highly significant difference in genotype frequencies at the MC1R mutation site c.361G > A between the LSB and LSS populations (Fisher’s exact test, P = 8.268 × 10 –25 ).

We detected 16 putatively imprinted genes, of which 8 were also found Baran et al using a much larger sample size, a highly significant enrichment (OR = 4,049; P < 10 −24 ).

Of those, 64 were upregulated, of which 55 showed strong upregulation, 4 were downregulated, and 8 showed no change in expression following induction of Gata1 in the G1ER system, demonstrating a highly significant overlap of our identified MURK genes with the G1ER-induced genes (p < 10 −24 ; see Fig. 4 B).

Second, genome-wide comparison indicates a highly significant inverse association of human-specific rearrangements with methylation levels (Kolmogorov-Smirnov test, D max = 0.23, p≈10 −24 ) ( Figure 1B ).

Over the 17 trials reporting on length of ICU stay, there is highly significant heterogeneity in the effect of vitamin C with I 2 = 90% ( p = 10 −24 ) ( Table 2 and Figure S1 in Supplementary file S1 ).

Firstly, as the source of this signature, the brown module’s gene set showed a highly significant enrichment in core processes such as the B cell receptor (BCR) signaling pathway (P=1.09e−24) and B cell activation (P=4.07e−17) in detailed pathway analysis.

Both the DLCV error as well as the error on the validation set show a highly significant correlation with the number of artificial datasets that is pooled, Pearson correlation of -0.91 ( p = 1.1 e - 24) and -0.95 ( p = 1.4 e - 31), respectively.

Compared with the expected overlap (based on a random distribution of mutations and polymorphisms), the overlap between polymorphisms in all of our MA lines and populations with those of natural variants is highly significant (Fisher’s exact test: SNV, p = 2 × 10 –24 ; indel, p = 1 × 10 –12 ; Fig. 8 ).

Intriguingly, DAVID analysis of the 82 LG-only DEPs revealed a highly significant over-representation of extracellular exosomes (53 proteins, p = 2E − 24) (Additional file 2 : Table S7), suggesting the possibility of differential exosome biogenesis and/or shedding in the two groups.

A test of homogeneity for the core matrisome proteins revealed a highly significant difference between native and dECM livers (χ 2 = 109.91, P = 2.76 × 10 −24 ), indicating that the relative abundance of core ECM components was markedly altered following decellularization.

disease controls were highly significant (P = 3×10 −24 ).

The observed correlation had a very high positive degree and was highly significant (R = 0.95, p-value = 3 × 10 -24 , see also the regression plot in Supplementary Fig.

briggsae AF16 ↔ HK104), Ts/Tv had a narrower range from 1.01 to 1.42 though the variation was highly significant ( P = 3.3 × 10 − 24 , X 2 test), primarily due to the unusually low ratio in the N2 ↔ CB4856 SNPs.

In one of these patients (Control 1), STRetch identified the highly significant expansion of SCA8 (noted above), a known but rare disease locus in ATXN8 with an outlier z-score of 11.11 ( p = 3.55e-24) and an estimated allele size of 54.4×.

Seventy three of the core response genes to MAB were also identified as part of the core response to MTB (Additional file 6 : Table S3), representing a highly significant overlap ( P < 5.482e-24, hypergeometric test) and suggesting a conserved role for type-I IFN responses across diverse mycobacterial species.

A chi‐squared test between treatment groups and gel categorization scores found a highly significant association between these two categorical variables (chi‐square test, p ‐value = 6.53 × 10 −24 , Figure 6 ).

While rs2647044 ( P = 3.85×10 −20 ) was still highly significant, rs9357152 ( P = 7.28×10 −24 ) became the most significantly associated SNP when the effects from the known HLA high-risk genotypes were accounted for in the logistic regression model.

Ingenuity pathway analysis identified highly significant overrepresentation of several pathways, including oxidative phosphorylation (OXPHOS; p = 8.1 × 10 −24 ) and mTOR signaling (p = 8.5 × 10 −10 ) ( Figure 5 C).

For example, when distinguishing individuals with MCI from those with CN, CR-Proxy showed a highly significant difference ( p = 8.14 × 10 − 24 , Cohen’s d = 0.68 ), compared to Brain-PAD ( p = 6.93 × 10 − 4 , d = − 0.25 ).

This difference was highly significant ( p = 8.23 × 10 −24 ).

This represents a highly significant (Chi-square test, P < 10E-24) deviation from expectation (108 deletions, 106 insertions, based on their proportion in the set of 5167 SVs that could be aligned to both apes).

In the ser2 Δ background strains, one‐way ANOVA identified highly significant differences among plasmid constructs ( P < 10 −23 ), and Tukey's HSD post hoc test resolved distinct complementation groups.

Consistent with Lirnet's predictions, we observed a modest but highly significant down-regulation (KS p-value<10 −23 ) of the Puf3 module in the RM mkt1Δ strain ( Figure 8C ).

For Abpa paralogues (Figure 6A ), we were unable to detect strong evidence of positive selection: M1/M2 test did not show evidence of selection (P > 0.25), while the M7/M8 test was highly significant (P < 10 -23 ).

Together they form a highly significant reaction set (P < 10 -23 for each of the three possible reaction pairs), whose congruence in genomic association is nearly perfect.