“highly significant”

This difference was highly significant, reflecting a strong main effect of stimulus type on mean RT ( F (1,108) = 167.01, p = 1e‐23), and remained significant within both HCs ( t (36) = 9.84, p = 9e‐12) and PwMS ( t (72) = 10.05, p = 2e‐15).

Summarizing the results to this point, the genome-wide association study revealed a highly significant association in the vicinity of Lgi2 , an extremely strong association (p = 1.05×10 −23 ) with the protein-truncating c.1552A>T (p.K518X) sequence change in the gene, and no significant association with any other locus.

One-way MANOVA showed that multivariate differentiation among the three major groups was highly significant (Wilk’s lambda = 0.4237, df1 = 56, df2 = 520, F = 4.98, p = 1.108E-23).

The results were highly significant: p = 1.11 × 10 −23 ( Fig 3A ); p = 5.29 × 10 −16 ( Fig 3B ); p = 3.88 × 10 −5 ( Fig 3D ); p = 1.38 × 10 −16 ( Fig 3E ); p = 1.00 × 10 −9 ( Fig 3F ).

Calculating the probability of observing this increase by chance according to the hypergeometric distribution indicates that this increase is highly significant ( P = 1.12E–23).

Both variants were associated with expression levels of NBR2, CTD-3199 J23.6 and LINC00854 genes with a highly significant eQTL evidence for NBR2, a BRCA1 neighbor gene ( p = 1.2 × 10 − 23 and p = 2.1 × 10 − 25 for rs9911630 and rs799916, respectively) (Additional file 2 : Figure S1).

For AUROC, the test showed highly significant differences ( χ 2 = 128.06, df = 6, P = 1.23 × 10 −23 ).

Indeed, 72 of the pivots were found to be essential, a highly significant fraction given the total number of essential genes in the network (22.6 essentials expected, P =1.42 × 10 −23 ).

Overall, there is a highly significant negative correlation (Spearman rank = -0.16, p = 1.6E-23) clearly demonstrating that larger proteins tend be less abundant than smaller proteins.

2e–g , red line, 7.3% ∆BV increase, p = 3.3 × 10 −22 ), but not in the contralateral TG (blue line, 0.02% increase, p = 0.92), the difference between the ipsilateral and contralateral delta blood volumes during stimulation being also highly significant (7.3% ∆BV increase, Fig. 2h , p = 1.7 × 10 −23 ).

Moreover, plotting the average intensity of green over red fluorescence for each of these cells resulted in a highly significant linear relationship (correlation coefficient r = 0.90, p=1.98 10 −23 in the example of petiole N° 42 in Figure 2B ).

A two-way ANOVA conducted across both cell lines demonstrated a highly significant main effect of drug concentration (F(1,80) = 199.32, p < 1.99e − 23), a significant interaction between formulation and concentration (F(3,80) = 8.01, p < 9.89e − 05), and a significant main effect of formulation type (F(3,80) = 4.08, p = 0.0095), indicating that cytotoxicity is concentration-dependent and formulation-specific, with more pronounced differences observed at higher doses.

Two hundred one APC 1311/+ pigs, representing 5 generations, were genotyped, revealing a highly significant correlation (Kruskal-Wallis test; P = 2.04e -23 ); pigs with A∗A genotype averaged 12 and with A∗G 107 polyps (last 40 cm of the colon) (interquartile range = 28.5 versus interquartile range = 138) ( Figure 1 C and D ).

The relationship between the reverted Tolerance value and Malignant cell kill rate is highly significant, P = 2.2 × 10 -23 , and the relationship between kill rate and recovery is also highly significant at P = 3.8 × 10 -7 .

Candesartan (angiotensin receptor blocker) regulated gene sets showed a highly significant ( p = 2.2x10 −23 ), negative 4.4-fold activation score ( Supplementary Table S1 ) corroborating the specificity of gene expression changes due to angiotensin II exposure.

Differences across quartiles were highly significant (global χ 2 p=2.3×10−23), reflecting clear enrichment of PRS benefit in individuals with greater genetic predisposition.

This correlation was highly significant (p = 2.5 × 10 -23 ).

The relative extent of pseudouridylation for the −1 mutants was reduced at both early (30 sec) and late (15 min) time points ( Figure 4e ) leading to a highly significant reduction in v0,rel (paired, two-tailed t-test, p =2.7×10 −23 , Figure 4f ).

Interestingly, the Receiver Operating Characteristic (ROC) analysis confirmed a highly significant relationship ( P = 2.8 x 10 −23 ) between the abundance of a species (number of reads) and its culturability ( Figure 4b ).

Moreover, an independent RF classification model applied to the primary tumors using TCGA DNAm data revealed a highly significant overlap in the top 100 most predictive genomic regions between the BM and the primary tumor classifiers (Hypergeometric test; P -value < 2.8e−23).

The Friedman test confirmed highly significant differences among the algorithms ( χ 2 = 121.98 , p = 2.96 × 10 − 23 ), justifying a detailed pairwise analysis.

Interrogation of eQTL databases revealed that rs13226913 has a highly significant cis-eQTL effect on C1GALT1 in peripheral blood cells ( P = 3.9 x 10 −23 ) with the T allele associated with lower mRNA levels ( S7 Table ).

47 The most recent GWAS for JT and QT intervals found highly significant associations, respectively, with rs17171731 ( P = 4E-23) and rs1335516 ( P = 1E-43, in very high LD with each other in European ancestry populations), with the AF risk allele associated with longer durations. 48 The GTEx project shows relatively low expression of FAM13B in human left ventricle (median value 5.5 transcripts per million), and no significant left ventricle FAM13B eQTLs are detected.

Previous reports have implicated deleterious coding variants in IFIH1 , the third member of the RLR family, as conferring protection against psoriasis 8 , 71 and psoriatic arthritis 72 ; the protective IFIH1 variants rs35667974 and rs1990760 are both highly significant in the current meta-analysis ( P = 5.0 × 10 −23 and 7.0 × 10 −50 , respectively) but not prioritised in credible sets due to insufficient effective sample size and the presence of a more strongly associated intronic variant (rs2111485), respectively.

In contrast to the auto-correlation, we observed a highly significant negative cross-correlation between IHO1 and DMC1, g ( x ) = –0.16054 and P = 5.67E–23, or RAD51, g ( x ) = –0.16592 and P = 8.76E–30, in the same pixel positions ( x = 0).