“highly significant”

The sodium-potassium ATPase subunit alpha 2 gene ( ATP1A2 ) was highly significant in the case-control comparison ( p < 4 × 10 −19 ).

Comparison of the WP and ACRG subclusters revealed that 67.39% (31/46) of MSS/EMT patients corresponded to the EMT cluster, whereas 73.42% (58/79) of MSS/TP53+ patients associated with the metabolism cluster, contributing to a highly significant statistical correlation between WP subclassification and ACRG subtyping ( P = 4.6 × 10 −19 ) (Tables S4 and S5 , Fig. 3A,B ).

DNM’s showed no enrichment of synonymous or tolerated missense variants (“T-mis”), but highly significant enrichment for both LOF (1.49-fold enriched, P = 4.63 × 10 −19 ) and damaging missense (D-mis) DNMs (1.35-fold enriched, P = 1.24 × 10 −13 ) ( SI Appendix , Table S4A ).

As can be seen, the difference between the mean final values of A (conditions in which the reaction is pre-specified) is highly significant ( p = 4.71×10 −19 ), whilst the difference between the mean final values of R (conditions in which the reaction is pre-specified) is not ( p = 0.175).

Further, when smaller geographical areas were considered (France is divided into 96 administrative units, called departments), these correlations remained highly significant (e.g., admissions to CCRUs: R smell = 0.76, p < 5 × 10 −19 ) (Fig. 1c ).

We found this CpG site highly significant in our sample of predominantly AA ( t = − 8.911; p = 5.074E−19).

Here, over all animal groups, ∆f% had a marginally significant effect on the ENV/TFS log-z-ratio [main effect: F(1,943) = 4.278, p =0.039] and stimulus condition had a highly significant effect on the ENV/TFS log-z-ratio [main effect: F(2,943) = 43.929, p =5.744 × 10 –19 ].

Ranking of patient samples by relative expression of these 54 genes identified high and low expressers, with the top 10% and the bottom 10% exhibiting a highly significant ( p = 5.79E-19) 8.9-fold difference in expression levels (Fig. 1 B, C).

We noted that the overlap between the TADA2B-correlated genes and our top 100 hESC CRISPR screen hits was highly significant ( P = 6 × 10 −19 ).

15 We also used the UMCG Groningen Gene Network tool which analyses data from 80 000 Gene Expression Omnibus microarrays to predict gene function in Gene Ontology Consortium terms, and found the top-scoring predictions for ARMC4 were highly significant and all involved in cilia functions: ciliary or flagella motility (p=6.10×10 −19 ), microtubule-based movement (p=1.16×10 −9 ) and cilium assembly (p=1.16×10 −9 ).

MIR1307 also maps to a highly significant SCZ GWAS locus (rs11191419, p value = 6.198e−19) in the PGC2 meta-analysis 30 .

We observed a moderate, but highly significant, correlation ( R Pearson = 0.4; P = 6.6 × 10 −19 ) between the TGS of the 461 genes in our study and their corresponding posterior probabilities [ 23 ] (Fig. 4c ).

Given the overall rates of linkage to both loci, we would expect less than one overlap by chance, and the observed overlap of 12 genes is highly significant (Fisher exact p -value = 8 × 10 −19 ).

Overall there is a highly significant overlap between differentially expressed and high Gini genes (Fisher exact test p value < 1e-18).

Tests for Neotoma species ( Figure 1 ) were also highly significant ( N. albigula p<10 -18 , N. goldmani p<10 -16 , N. lepida p<10 -11 , N. mexicana p<10 -5 , N. micropus p<10 -13 , and N. phenax p<10 -73 ); some areas of overprediction (e.g., N. mexicana in the Yucatan Peninsula) represent either prediction into areas not inhabited for historic reasons (18) or true overprediction error.

Remarkably however, 79 of the CF-Meta enriched gene sets were also enriched in the CFG analysis, which was highly significant (Fisher’s exact p < 1e − 18).

Language Related to Self-experience Could Infer Clinical Symptoms CCA conducted in the training sample revealed a highly significant relationship between language features and the PANSS ( r = .62, P < 10 −18 ; figure 3A ), and those linear combinations of the PANSS subscales and language factors were validated in the testing set ( r = .59, P < 10 −6 ; 3B).

The results as shown in Table 1 revealed highly significant differences ( p < 10 −18 ) for all six measured metrics, including Avg_Area, Avg_Migration, Avg_Motility, Avg_Irregularity, Avg_Directness, and Avg_Optical_Thickness.

These differences in success rates were highly significant (adjusted P value <10 −18 ) ( SI Appendix , Fig.

The signaling events mediated by HDAC Class III was highly significant at the p < 0.01 × 10 −16 level as was the glucocorticoid receptor regulatory network at the p < 0.01 × 10 −6 level.

These results were confirmed by a paired t-test comparing the scores within each speaker-listener pair which showed a highly significant difference (story: t = 9.08, df = 665, p < 1.18 × 10 −18 , Cohen’s d = 0.42, partner: t = 7.91, df = 615, p < 1.18 × 10 −14 , Cohen’s d = 0.41).

Of the 171 isolates with a putative resistance mutation (Figure S1), 107 (62.6%) had an available DST result for INH, with 99 reporting a resistant phenotype leading to a highly significant association between the putative drug resistance mutations and DST phenotype (Chi-squared P < 1.4 × 10 –18 ).

However, consistent with the previous analysis, there was a highly significant interaction effect of presentation stage ×image set type (F 1,408 = 85.2, p=1.5 × 10 −18 , η 2 p = 0.17).

Using a chi-squared test, a significant association was detected between the ihs locus and SSLP markers on chromosomes 4, 6, 18, 19, and X, with an especially highly significant association at D18Mit233 ( P = 1.78E-18) ( Table 1 ).

Intriguingly, 80% of the arginine ADPr-modified proteins were also annotated as glycoproteins, representing a highly significant enrichment (p = 1.8 × 10 −18 ), in agreement with site-specific analysis ( Figure 3 E).