“marginally significant”

We performed a sensitivity analysis to test the reliability of the meta-analysis, which showed that removing any one study would not lead to a marginally significant difference between the two groups ( P < 0.0001; Supplementary Figs. 35–36 ).

Using α=0.05 as the significance threshold, our analysis revealed a highly significant difference at F442 ( P < 0.0001) and a marginally significant difference at F447 ( P = 0.0468).

Enrichment analysis of these null variants in heterozygosity against gnomAD-NFE revealed a marginally significant enrichment (OR, 2.39 [95% CI, 1.65–3.47], P <0.0001) that was not validated against internal controls (OR 1.34 95% CI, 0.74–2.42], P =0.337; Table S9 ), reinforcing our approach of treating cases with heterozygous null variants in TRIM63 as negative.

Detection of recombination, using the pairwise homoplasy index test (PHI-test), was marginally significant in the HCV Sanger data set ( P = 0.043), and highly significant in the HIV-1 data set ( P < 0.0001).

Those shifts ranged from a modest four-percentage-point increase in support of legalization to a substantial 12-point jump in the share who said it us “safe for pit bulls to live in residential neighborhoods.” The differences in percentages from 2014 to 2018 for the first three questions in Figure 1 are all highly significant ( p < 0.0001), while the four-point difference in support for legalization shown in the final column of the figure is marginally significant ( p = 0.06).

The differences among major gene pools were highly significant among diploid (F 5,96 = 212, p <0.0001) and marginally significant among tetraploid (F 1,39 = 4.8, p = 0.03) accessions.

A mixed effects model that accounted for the structuring effect of Municipality found that total Cl was the single best predictor of Sobs, with a marginally significant negative effect of WT (observed vs fitted R 2 = 0.58, P<0.0001).

Differences within groups were marginally significant or non‐significant, while the difference among groups was highly significant ( P < 0.0001).

For exposure assessment ( Figure 9 ), there was a marginally significant association between UPF intake and risk of CRC (RR = 1.27; 95%CI: 1.15–1.42, p < 0.0001) in FFQ, and the heterogeneity was more heterogeneity ( p = 0.008; I 2 = 63.3%).

rigaudi and marginally significant for E. artemiae ( t = −6.7 and −2.2, P < 0.0001 and P = 0.05, respectively).

This analysis revealed that samples of genotype SBb display significantly lower relative amounts of SiOR89 (by 50%) and marginally significant for SiOR88 (by 37%), as compared with SBB samples from either monogyne or polygyne colonies ( fig. 1 c ; P < 0.0001 and P = 0.07, respectively, Tukey post hoc tests following a mixed effects model analysis).

Substitution saturation is marginally significant for the SKL1 family (p = 0.07) and highly significant for the SK family (p<0.0001).

The difference between the treatments was marginally significant at Day 4 and 7 (P = 0.0532 and 0.0560, respectively), and highly significant by Day 14 (P < 0.0001; Fig 5D ).

E2 treatment when compared to DHT treatment in ovariectomized females resulted in activation of Nrf2 that was marginally significant (p-value = 1E-4) (Lane 1).

Immune-related genes and marginally significant LD blocks ( P< 1.1E-04) immediately adjacent to significant association clusters were also examined as potential candidates.

These effects on theta power included: a highly significant reduction at frontal sites (p = 1.55×10 −4 ) and a marginally significant reduction at parietal sites (p = 0.0499) in Sp4 hypomorphic animals, as well as a slight but significant increase at occipital sites (p = 0.0203) in wildtype animals ( Fig 4B ).

Disease had a highly significant ( p = 0.00017) impact on cell composition and steroid use was marginally significant ( p = 0.04680).

Post-hoc analysis of the marginally significant interaction (T x Day, Table 2 ) revealed significant effects of temperature on Day 11 (linear contrast with Bonferroni correction; Ζ = −4.045, p = 0.0002), but no difference between temperatures on Days 9 and 10.

In Model 2 (NB Regression with Region), only episodes remained highly significant (β = 0.00505, SE = 0.00137, z = 3.69, p = 0.0002), while latitude became marginally significant ( p = 0.096); area lost significance ( p = 0.119).

p ‐values estimated by Mantel tests were highly significant or significant at p = .0002–.009 in nine cases and marginally significant at p = .061 in one case.

There was significant heterogeneity ( I 2 = 64%, p = 0.1) so a random effects model was used, and the results revealed a marginally significant association between CGGGG Indel polymorphisms in the IRF5 gene and pSS, with a pooled OR and 95% CI of 1.69 (1.27, 2.24) ( z = 3.60, p = 0.0003, Fig. 3b ).

After adjustment for confounders, apoJ at baseline and at 18 months was marginally significant after adjustment for multiple comparisons ( P = .0004).

Two SNPs located in genes that were implicated by previous GWA studies of ALS were marginally significant in the pooled analysis of discovery and replication samples: rs17174381 in DPP6 (p = 4.4×10 −4 ) and rs6985069 near ELP3 (p = 4.8×10 −4 ).

The np-MANOVA based on the first two coordinates of individuals in MDS clearly demonstrated highly significant differences between sexes ( F = 175.89, P = 0.0005) and marginally significant differences among populations ( F = 1.95, P = 0.07).

We further estimate gene-based noncoding DNMs by segment-based test in the intergenic region, and only CSMD1 reached statistically significant ( p = 2.79 × 10 −7 ) in SPARK and marginally significant ( p = 5.47 × 10 −4 ) in SSC ( Table S8 ).