“marginally significant”

Indeed, only cg00574958 (and related loci cg17058475 and cg09737197) at CPT1A remained significant at the epigenome-wide level ( P < 1.1 × 10 −7 ), while other loci were marginally significant with AUC at P < 5.5 × 10 −6 .

For example, one colocalized SNP for AUD and smoking initiation, rs6589386 on DRD2 , was marginally significant in the single-trait GWAS ( p -value = 7.17E-06) but attained GWS in MTAG ( p -value = 3.58E-10) (Fig. 3B ).

Based on a Bonferroni-adjusted significance level of 0.00009, we also find a marginally significant correlation between RGD1307603 , a gene with no known function, and QUICKI ( r = 0.544, P = 0.00000925).

Even among the 1223 marginally significant ( p < 1 × 10 −5 ) probes identified by Hannon and colleagues [ 4 ] in the discovery sample (Table S3 in [ 4 ]) there was minimal overlap in differential methylation signal at the probe ( N = 2) or gene ( N = 9 and N = 3, respectively) levels.

Marginally significant associations (p < 1 × 10 −5 ) are reported in Table S2 .

We tested the five significant or marginally significant SNPs (p < 10 −5 ) using standard linear regression models adjusted for the same covariates as above ( S1 Table ).

Loci harboring marginally significant evidence for association at P <10 −5 were examined for independent signals via regression analyses in PLINK. 16 A term was added to the regression model including the lead SNP as a covariate, and SNPs within the same candidate gene, or ±200 kb if the candidate gene region was <200 kb, were evaluated for maintaining array-wide significance.

Using fixed-effects model, the results showed that the patients with hypothyroidism had a marginally significant reduction in CI compared with healthy controls (WMD=-0.53, 95%CI[-0.65, -0.41], P <0.00001), and heterogeneity analysis showed large heterogeneity (Tau2=0.21, Chi2=44.02, P < 0.00001, I 2 = 93%).

Two of these SNPs, rs7948623, rs11230664, are also genome-wide significant GWAS SNPs for pigmentation variation in Africans, while the third, rs3741265, is marginally significant ( p < 10 −5 , Fig. 5 ).

Increasing the number of marginally significant height SNPs in the estimates of inbreeding coefficients increased the difference with respect to the random SNPs (P < 2 × 10 −5 for top 2,500 SNPs and P < 9 × 10 −8 for top 5,000 SNPs), further providing evidence of height-based assortative mating in the ARIC European cohort (Tables 2 and 3 ).

Three significant loci were identified by this analysis ( P < 0.000002), along with a fourth marginally significant ( P < 0.00003).

35 , 36 In addition, the metaboQTL (lead SNP: rs12118651, N = 1,981, p = 3.52 × 10 −15 ) for kynurenic acid was confirmed, while previous studies have reported marginally significant results of this signal in urine (EUR, N = 1,672, p = 3.30 × 10 −5 ), 37 serum (EUR, N = 1,960, p = 4.52 × 10 −6 ), 8 and blood (EUR, N = 86,507, p = 5.41 × 10 −9 ). 38 This novel signal among EAS might be attributable to the specificity of race or the relatively large sample size.

In Table 1 , the results of the model averaging are displayed with the factors contained in the final, all being highly significant (tissue p = 4 × 10 −5 ; density/tissue p = 0.0006; density p = 0.004) with the exception of the factor gene, which was marginally significant ( p = 0.06).

While sample size used for this analysis is fairly small (due to the exclusion of netted and orange or green rind accessions), the strongest genome-wide effect that we found for this trait, on chromosome 10, was still marginally significant at FDR30% (P = 4 × 10 −5 , MLM).

The association between rs643892 in LRP5 and LS-BMD was marginally significant ( p = 8.63 × 10 −5 ).

A mixed effects model that accounted for the structuring effect of Municipality found that total Cl was the single best predictor of Sobs, with a marginally significant negative effect of WT (observed vs fitted R 2 = 0.58, P<0.0001).

For example, the WTCCC [13] required a marginally significant (p-value<10 −4 ) GWAS SNP to support the evidence at a genome-wide significant imputed SNP.

The differences among major gene pools were highly significant among diploid (F 5,96 = 212, p <0.0001) and marginally significant among tetraploid (F 1,39 = 4.8, p = 0.03) accessions.

Again, we did not observe an increase in the proportion of adult mosquitoes, rather a marginally significant decrease with VIT8× (Fig. 1A , proportion of adults: p < 0.0001; AUX vs GF, VIT4×, or VIT8×: p < 0.0001; GF vs VIT4×: p = 0.73; GF vs VIT8×: p = 0.058; Supplementary Data 2 ).

E2 treatment when compared to DHT treatment in ovariectomized females resulted in activation of Nrf2 that was marginally significant (p-value = 1E-4) (Lane 1).

60 min: adjusted p = 0.151) or marginally significant (e.g., 70 vs. 50 min: adjusted p = 0.0001), and declined slightly thereafter.

Comparative statistical analysis revealed highly significant differences between the late/early improvement ratio for sleep and that of cognitions/mood ( p = 0.0001), significant differences with re-experiencing ( p = 0.0094), a marginally significant difference with avoidance ( p = 0.0541), and no significant difference with arousal ( p = 0.1383).

rigaudi and marginally significant for E. artemiae ( t = −6.7 and −2.2, P < 0.0001 and P = 0.05, respectively).

Differences within groups were marginally significant or non‐significant, while the difference among groups was highly significant ( P < 0.0001).

Detection of recombination, using the pairwise homoplasy index test (PHI-test), was marginally significant in the HCV Sanger data set ( P = 0.043), and highly significant in the HIV-1 data set ( P < 0.0001).