0.33 ± 0.13 MPa), though this difference narrowly missed significance ( p = 0.099).
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This result varied somewhat across permutations of the dFNC analysis, but oscillations were significantly dampened in autism in 5/9 permutations, and narrowly missed significance in 4 more, making it a fairly robust finding ( Fig. 6 ) in the sensitivity analysis, though it did not replicate in test-retest.
On multivariate logistic regression modelling, after adjusting for age, PSA and DRE, hemospermia was predictive of prostate cancer although narrowly missed significance ( 72 ).
Site of Origin (SO) was significant for all traits with the exception of saccharification potential for which the SO effect narrowly missed significance with the random factors block and run included in the GLM.
Additional ADME proteins were differentially expressed but narrowly missed significance, namely the ABC transporter ABCA2, alcohol dehydrogenases ADH4 and ADH6, glutathione S-transferases GSTA2 and MGST3, solute carrier organic anion transporter SLCO1B3 , and the superoxide dismutase SOD3 that tended to be reduced, whereas GSTM1 and the solute carrier SLC22A18 tended to be considerably higher (Fig. 2 B; Supplementary Table 1 ).
The ORs for disease risk for each clade B allele, in all cases the minor allele, suggested that the clade B alleles are protective of AD risk in the AS cohort, although in each case the association narrowly missed significance.
All 129 hits, along with two drugs that narrowly missed significance in the primary assay, were then evaluated for their ability to affect the degradation of photoconverted Dendra2-LC3 ( Fig. 5 B , Fig. 5-source data 1 ).
Although the time * group effect on the BDI narrowly missed significance after FDR correction, the medium-to-large reduction observed in the MBCT arm ( d = 0.71) echoes meta-analytic evidence that MBCT alleviates acute depression and prevents relapse [ 48 , 49 ].
In our previous report from the EpiPath cohort, multiple correction testing during our survey of the complete immune system meant that NK cells only narrowly missed significance ( 18 ), and the only other comparable study did not investigate NK cells ( 64 , 112 ).
In another placebo-controlled study in patients with symptom duration of <4 weeks and reduced contrast sensitivity, simvastatin (a hypercholesterolemia medication) narrowly missed significance on the primary efficacy outcome (contrast sensitivity), but improvements were noted for VEP latency and amplitude. 58 However, imbalances in randomization and technical issues may have contributed to the observed effects. 59 A study in ON testing possible neuroprotective effects of phenytoin, an anticonvulsant, has recently completed, and another study testing effects of amiloride hydrochlorothiazide, a diuretic, is currently underway.
This finding was probably due to the vitamin C content in fruit; however, this association narrowly missed significance following multivariate adjustment.
(Note that the left pre-SMA/anterior-mid cingulate narrowly missed significance for modulation by linguistic demand, as seen in Figure 2 ).
S2 and Table S2 ) and narrowly missed significance for women married to patrilateral relatives (OR = 1.07, 95% CI [0.99–1.18]).
Furthermore, some factors (histone–MPO, H3Cit, and DNase activity) correlate positively with the growth progression of A.pp in BALF, but narrowly missed significance ( Figures 5E, F, H, I ).
Further meta-analyses showed that glutamate levels within the ACC were not correlated with co-localised neural activity during either cognitive control or emotion processing, however, the latter meta-analysis narrowly missed significance.
In the model with ADHD symptoms as outcome, this specific indirect effect narrowly missed significance (partially standardised specific indirect effect through negative parenting behaviour: − 0.102; see Table 2 ).
One study examined symptom presentation in a sample of high-functioning children referred for an ASD assessment ( Mandy et al., 2011 ) and reported that relatively more males were diagnosed with a full-ASD subtype and relatively more females were diagnosed with a partial-ASD subtype although the difference narrowly missed significance.
reported a nearly 35‐meter improvement in 6MWD and a 2.5‐fold increase in the odds of WHO class improvement, though the NT‐proBNP change narrowly missed significance [ 7 , 8 , 20 , 21 , 22 ].
Chronic alcohol consumption also altered other mitochondrial processes, elevating TCA cycle intermediates like succinate, citrate, and malate in the EF mouse livers, although malate narrowly missed significance ( Fig. 8 A , supplemental Fig.
Soluble CD62P demonstrated a similar pattern, although the difference between participants on cART who used tobacco and cART-naïve non-users narrowly missed significance.
Narrowly missed significance on the primary endpoints is unlikely to be due to a high placebo response, as the placebo rate was in line with clinical trials of other approved drugs for the treatment of DS. 28 , 29 , 30 , 31 However, as mentioned above, the observed placebo response in this trial was higher than in the phase 2 study.
Another gene, ANKH was upregulated in medial condyle cultured MSCs, and narrowly missed significance in uncultured CD45 − CD271 + cells.
These GO terms, the overall skew in gene loading frequencies toward positive loadings (Figure 3E ), and the common energy metabolism genes with negative loading (Figure 3D ; also, several muscle‐related GO terms narrowly missed significance) suggest that variation reflected in PC1 is likely linked to differences in tissue composition (possibly reflecting a varying amount of the functionally distinct foregut portion of the gut) of samples.
For ONS volumes, correlation coefficients in the normal ICP subgroup were relatively high and p -values narrowly missed significance.
Behavioral Overall, learning narrowly missed significance, as revealed by a repeated measures ANOVA looking at the effect of the within-subject factor “block” (four blocks à 25 trials) on performance ( F 2.02, 88. 97 = 3.00, p = 0.05, η p 2 = 0.06).