“nominally significant”

Of the 629 candidate genes associated with circulating vitamin D in the Phase 1 gene-set, 55 had nominally significant expression change after supplementation ( P < 0.05).

Overall, the direction of effects did not change and remained nominally significant ( P < 0.05).

Nominally significant ( p < 0.05) negative association was seen between PRS SCZ and EY in the NPSYCH group, but not in the PSYCH group (Fig. 3b ).

Of the 21 loci, 13 were nominally significant (p<0.05) in UKBB, including one variant (rs4388642 in CFH, p=1.82×10 -17 ) reaching Bonferroni-corrected significance (Supplementary file Table S3).

Given the possibility that the observed lack of correlation for LDL-C could be due to reduced power from a limited number of variants attaining a suggestive p -value (<5 × 10 −07 ), we repeated the analysis with a subset of 122 nominally significant ( p -value < 0.05) LDL-C associated variants in this locus.

A number of nominally significant ( p -value < 0.05) causal effects that did not survive multiple testing adjustments were detected (Fig. 5 ).

All CC lead signals were at least nominally significant ( P < 0.05) in cervical dysplasia analysis, rs4849177 and rs35508382 were also genome-wide significant ( Supplementary Material, Table S7 ), confirming the overlap of genetic risk factors for cervical dysplasia and cancer.

Nominally significant association (P<0.05) was observed for markers in: TCF7L2, RBMS1, CDKAL1, ZNF239, KCNQ1 and TCF1 and a significant bias (P<0.05) towards OR>1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans.

Results Allelic associations The European Caucasian sample set revealed nominally significant ( P <0.05) associations with gout at two block-3 SNPs: rs475688 and rs7932775 (SLC22A12; OR = 1.26, P = 0.043; OR = 1.32, P = 0.033, respectively) (Table 1 ).

A few traits exhibited nominally significant associations ( p < 0.05), but the effect directions were inconsistent across traits and sensitivity analyses (weighted median, MR Egger) did not uniformly support these findings.

Despite the much narrower range of ages in this cohort, nine (29.03%) of the 31 transcripts for which data were available displayed a nominally significant ( P < 0.05) association between transcript abundance and brain development (Supplemental Table 2), with several transcripts showing highly significant associations with developmental age (Supplemental Fig. 3).

Briefly, drugs were ranked by their frequency of being at least nominally significant ( p < 0.05) across the four time windows and eight models ( Table 4 ).

Seven of the 14 CKD-associated CpG sites showed nominally significant associations ( P < .05) with eGFR, of which one surpassed multiple testing correction (cg18633191 located in C4orf50, P < .004).

However, 8 factors were nominally significant ( p <0.05): city, age, obesity, physical appearance, parenting style, studying communication skills with children, confidence, and working hours.

Prior to RF model training, a feature selection was performed, and only species that showed nominally significant differential abundance in t ‐test and/or LinDA analysis ( p < 0.05) were used as features for training.

More specifically, out of 4,350,741 SNPs that indicated no heterogeneity between studies, those 185,986 SNPs that were nominally significant (p<0.05) and showed the same effect direction in all three studies were considered for the pathway enrichment analysis.

Nevertheless, the sign and estimates of the effect sizes were all consistent, and most of the relevant associations were found nominally significant (P < 0.05).

After sensitivity analysis and FDR correction, the following results were obtained: Two-sample MR analyses using various brain-related omics datasets and ADs revealed that in the CSF metabolites-ADs analysis, several diseases exhibited nominally significant causal relationships ( P < .05) in the initial analysis.

Notably, 11 loci exhibited nominally significant ( P < 0.05) association with IGCTs: CLPTM1L , PITX1 , SPRY4 , TNXB , two loci of BAK1 , KATNA1 , DEPTOR , GAB2-NARS2 , HNF1B , and TKTL2 (Fig. 4 ; Supplementary Data 1 ).

The expression level of 186 genes showed a nominally significant difference in expression following HS (p<0.05: 105 increased; 81 decreased), of which 12 achieved genome wide significance (q<0.05: all increased with HS) ( Figure 2 ; Table S2).

Markers with nominally significant p-values in one or more cell populations ( P ≤ 0.05; e.g CD39, CD38, Ki-67, PD-1) were visualized in boxplots; statistical significance computed using the linear mixed model were further confirmed using non-parametric Wilcoxon rank sum test.

While on the whole, none of the cis -SNPs were genome-wide significant in the GWAS data, they were significantly enriched for nominally significant (p<0.05) SNPs in the BMI GWAS results ( [65] , binomial p = 0.007), indicating either their pleiotropic effect, or metabolic trait regulation through small RNA expression levels. rs2440129 was nominally significant in the BMI GWAS lookup [65] , while mir-195-3p was significantly associated with both rs2440129 in cis (FDR<5%, p<2.4×10 −5 ), as well as BMI (FDR<5%, p<3.9×10 −3 ) and PTFM (FDR<5%, p<4.1×10 −3 ), suggesting a mechanism for the rs2440129 association.

study 7 , 147 pQTLs (52.88%) were nominally significant ( P < 0.05) and accessible for comparisons.

We also identified 35 nominally significant differentially abundant proteins ( P < .05), with 84% of these detected at higher abundance after HS exposure.

The following criteria were used to determine the differential abundance of proteins in the septic/aseptic group: (i) proteins that were identified in at least 60% of the samples in at least one group and (ii) for which a nominally significant difference in protein abundance was observed between conditions (unadjusted p < 0.05).