“nominally significant”

More specifically, out of 4,350,741 SNPs that indicated no heterogeneity between studies, those 185,986 SNPs that were nominally significant (p<0.05) and showed the same effect direction in all three studies were considered for the pathway enrichment analysis.

Other nominally significant associations with INSIGF (P<0.05 and P BH >0.05) are reported in table S7 and in figure 3 .

Nevertheless, the sign and estimates of the effect sizes were all consistent, and most of the relevant associations were found nominally significant (P < 0.05).

The expression level of 186 genes showed a nominally significant difference in expression following HS (p<0.05: 105 increased; 81 decreased), of which 12 achieved genome wide significance (q<0.05: all increased with HS) ( Figure 2 ; Table S2).

While on the whole, none of the cis -SNPs were genome-wide significant in the GWAS data, they were significantly enriched for nominally significant (p<0.05) SNPs in the BMI GWAS results ( [65] , binomial p = 0.007), indicating either their pleiotropic effect, or metabolic trait regulation through small RNA expression levels. rs2440129 was nominally significant in the BMI GWAS lookup [65] , while mir-195-3p was significantly associated with both rs2440129 in cis (FDR<5%, p<2.4×10 −5 ), as well as BMI (FDR<5%, p<3.9×10 −3 ) and PTFM (FDR<5%, p<4.1×10 −3 ), suggesting a mechanism for the rs2440129 association.

Despite the much narrower range of ages in this cohort, nine (29.03%) of the 31 transcripts for which data were available displayed a nominally significant ( P < 0.05) association between transcript abundance and brain development (Supplemental Table 2), with several transcripts showing highly significant associations with developmental age (Supplemental Fig. 3).

Results Allelic associations The European Caucasian sample set revealed nominally significant ( P <0.05) associations with gout at two block-3 SNPs: rs475688 and rs7932775 (SLC22A12; OR = 1.26, P = 0.043; OR = 1.32, P = 0.033, respectively) (Table 1 ).

We also identified 35 nominally significant differentially abundant proteins ( P < .05), with 84% of these detected at higher abundance after HS exposure.

study 7 , 147 pQTLs (52.88%) were nominally significant ( P < 0.05) and accessible for comparisons.

To underpin this, we further checked the directions of effect of all nominally significant a-DMSs ( P < 0.05) and found that methylation changes tended to be negatively associated with maternal smoking between 0 and 4/5 years (Fig. 4b ) and, moreover, that 721/971 (74.2%) a-DMSs showed a stronger decrease in methylation levels from 0 to 4/5 years (Additional file 1 : Table S7).

Effect estimates for most proteins remained consistent after adjustment for these factors, but standard errors increased such that only Nt-proBNP, CXCL13 and the complement factors remained significant at the Bonferroni-adjusted threshold (Table 2 ) although all proteins except IL-1RA and tPA remained nominally significant at p < 0.05.

Four genetic variants (rs266729 [ ADIPOQ ], rs6017317 [ HNF 4A ], rs5215 [ KCNJ 11 ] and rs7177055 [ HMG 20A ]) showed a nominally significant association with postpartum abnormal glucose tolerance ( P < 0.05, respectively).

The following criteria were used to determine the differential abundance of proteins in the septic/aseptic group: (i) proteins that were identified in at least 60% of the samples in at least one group and (ii) for which a nominally significant difference in protein abundance was observed between conditions (unadjusted p < 0.05).

On the other hand, among the 986 SNPs with estimated PPR >99%, 47% were nominally significant with p < 0.05 in the replication cohort 23andMe, and 79% with consistent direction of effects.

Briefly, drugs were ranked by their frequency of being at least nominally significant ( p < 0.05) across the four time windows and eight models ( Table 4 ).

To ensure a sufficiently large sampling distribution, we restricted our analysis to six nominally significant ( p < 0.05 952 ≈ 5.25 × 10 − 5 ) gene-trait combinations with at least 10 individuals who are either CH variant carriers or with ≥2 pLoF or damaging missense/protein-altering variants on the same haplotype ( STAR Methods ).

Results were considered nominally significant at p < 0.05 (two-tailed).

If one is interested in filtering a large list of nominally significant findings (p < 0.05) to identify a subset most worthy of follow-up, instead of characterizing the evidence for a single finding, our flexible scoring system can be utilized in this setting as well.

In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant ( p < 0.05) and retained the same positive direction, suggesting persistence of associations.

Nevertheless, in the Breslow–Day test, we detected that only two (rs72854462 and rs1438898 mapped to TEX41 gene) of the 821 tested SNPs were nominally significant ( p < 0.05), signaling heterogeneity in the odds ratios (OR) of these variants between Mexico and Colombia (see Supplementary Table 3 ).

Five of these 20 SNPs yielded at least nominally significant association with BMI ( P < 0.05) in the discovery cohort, representing four different independent loci.

Only those SNPs are shown that have a nominally significant ( p < 0.05 ) association with at least one of the latent variables.

After conducting heritability analysis across 139 immune traits, we identified 10 immune traits with significant heritability (FDR p < 0.05), and 23 other traits with nominally significant heritability (p < 0.05) in at least one ancestry group.

In females, we found a significantly higher proportion of CpGs showing increased variability with age among nominally significant ( p < 0.05) CpGs under inactivation, but not among CpGs escaping inactivation.

Among these CpGs, 129 were nominally significant ( p value < 0.05) in at least one of our models (total number of ACEs: 14 CpGs; total number of ACEs categorical, 1–3 vs. 0: 8 CpGs; 4–10 vs. 0: 12 CpGs; 4–10 vs. 1–3: 15 CpGs; mutually adjusted, emotional abuse: 13 CpGs; physical abuse: 11 CpGs; sexual abuse: 11 CpGs; emotional neglect: 19 CpGs; physical neglect: 10 CpGs; domestic violence: 15 CpGs; substance abuse: 20 CpGs; mental illness: 23 CpGs; incarceration: 13 CpGs; divorce: 9 CpGs), although none remained significant after adjusting for multiple comparisons in our EWAS (Additional file 2 : Table S1).