“nominally significant”

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1

23 We specifically identified outcomes for which meta-analyses of observational studies showed nominally significant associations (at P≤0.05), did not have large between study heterogeneity, were based on evidence from more than 500 cases (or more than 5000 total participants if the type of metric was continuous), and showed no evidence of small study effects or excess significance.

Nominally significant associations (directionality and strength shown by beta estimates) are bolded (p < 0.05) and significant associations after correcting for testing 6 modules and 22 traits (FDR) are bolded and in red.

Nominally significant association (P<0.05) was observed for markers in: TCF7L2, RBMS1, CDKAL1, ZNF239, KCNQ1 and TCF1 and a significant bias (P<0.05) towards OR>1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans.

Fourth, a nominally significant association (p-value < 0.05) was considered “weak” evidence.

We included 412 heritable traits with nominally significant p -value ( P < 0.05) from the common variant-based h 2 estimation (as implemented in ldsc) in the downstream analyses.

Differentially abundant proteins in each group were defined based on the following criteria: Proteins identified in at least 60% of samples in at least one group and nominally significant difference in protein abundance (unadjusted p < 0.05).

Nominally significant ( p < 0.05) negative association was seen between PRS SCZ and EY in the NPSYCH group, but not in the PSYCH group (Fig. 3b ).

To determine if any annotations were enriched in both mouse and human, even though individual genes were not shared, separate lists of genes nominally significant in human (915 genes p ≤ 0.05) and human homologues of the 42 mouse genes with p ≤ 0.05 were entered into DAVID.

Despite the much narrower range of ages in this cohort, nine (29.03%) of the 31 transcripts for which data were available displayed a nominally significant ( P < 0.05) association between transcript abundance and brain development (Supplemental Table 2), with several transcripts showing highly significant associations with developmental age (Supplemental Fig. 3).

Results Allelic associations The European Caucasian sample set revealed nominally significant ( P <0.05) associations with gout at two block-3 SNPs: rs475688 and rs7932775 (SLC22A12; OR = 1.26, P = 0.043; OR = 1.32, P = 0.033, respectively) (Table 1 ).

The ANCOVA for age was significant (HLA-DRB1 and HLA-DPA1 p < 0.0005, while CD74 was nominally significant p = 0.05).

Of the 629 candidate genes associated with circulating vitamin D in the Phase 1 gene-set, 55 had nominally significant expression change after supplementation ( P < 0.05).

Of the 21 loci, 13 were nominally significant (p<0.05) in UKBB, including one variant (rs4388642 in CFH, p=1.82×10 -17 ) reaching Bonferroni-corrected significance (Supplementary file Table S3).

study 7 , 147 pQTLs (52.88%) were nominally significant ( P < 0.05) and accessible for comparisons.

A number of nominally significant ( p -value < 0.05) causal effects that did not survive multiple testing adjustments were detected (Fig. 5 ).

We also identified 35 nominally significant differentially abundant proteins ( P < .05), with 84% of these detected at higher abundance after HS exposure.

Briefly, drugs were ranked by their frequency of being at least nominally significant ( p < 0.05) across the four time windows and eight models ( Table 4 ).

The following criteria were used to determine the differential abundance of proteins in the septic/aseptic group: (i) proteins that were identified in at least 60% of the samples in at least one group and (ii) for which a nominally significant difference in protein abundance was observed between conditions (unadjusted p < 0.05).

A few traits exhibited nominally significant associations ( p < 0.05), but the effect directions were inconsistent across traits and sensitivity analyses (weighted median, MR Egger) did not uniformly support these findings.

On the other hand, among the 986 SNPs with estimated PPR >99%, 47% were nominally significant with p < 0.05 in the replication cohort 23andMe, and 79% with consistent direction of effects.

Seven of the 14 CKD-associated CpG sites showed nominally significant associations ( P < .05) with eGFR, of which one surpassed multiple testing correction (cg18633191 located in C4orf50, P < .004).

However, 8 factors were nominally significant ( p <0.05): city, age, obesity, physical appearance, parenting style, studying communication skills with children, confidence, and working hours.

Results for the well-being score were all directionally consistent but none were nominally significant ( P < 0.05). 4. 2-sample MR with non-overlapping depression GWAS Using the PA and ST instruments identified in our MRLap analysis we provide further evidence for the role of PA in depression using the summary statistics from the Wray et al.

More specifically, out of 4,350,741 SNPs that indicated no heterogeneity between studies, those 185,986 SNPs that were nominally significant (p<0.05) and showed the same effect direction in all three studies were considered for the pathway enrichment analysis.