“nominally significant”

Step 5: We generate a ranked list of drug repositioning candidates and MOA categories that show enrichment of nominally significant ( p < 0.05) gene-based associations (MAGMA and S-PrediXcan) across compounds within each category.

Epigenome-wide association study of Frailty Index Testing 723,029 lsBINs in 50 FI discordant MZ twin pairs (Gr1) implementing paired t tests revealed overall N D = 27,485 bins that showed nominally significant associations ( P < 0.05), and of these, the top 20 association signals were ranged P = 7.01 −5 to 2.17 −6 .

Since the primary endpoints in both trials did not reach statistical significance, all other p-values <0.05 for both predefined subgroups and post hoc analyses are considered nominally significant and hypothesis-generating.

In light of this, we noted both CpGs that were nominally significant ( p < 0.05) and those that were significant after accounting for 13 tests ( p < 0.0038).

Identification of QTL and Their Confidence Intervals Although many marker x family combinations were nominally significant to highly significant (comparison wise p ≤ 0.05 to p ≤ 0.001), very few remained significant after PFP corrections for multiple tests.

However, the ADL scale had a nominally significant ( p ‐value <0.05) association with total cerebellar volume and cervical spinal cord CSA (Table S4 ).

Under conservative Bonferroni correction (α = 0.0033), the NLR–dyspnea ( p = 0.001) and MUST–appetite loss ( p = 0.001) associations remained statistically significant; the NLR–physical functioning, NLR–role functioning, and MUST–nausea/vomiting associations were nominally significant ( p < 0.05) but did not survive Bonferroni correction and are reported as exploratory.

We found nominally significant ( P <0.05) evidence of association for 22 variants (6 IBD, 10 CD, and 6 UC; Table 2 ).

We also discuss nominally significant results ( P < .05).

Pooled analyses were considered to be nominally significant if the effect estimate had a P value <0.05.

To be included as a training feature in the outer loop, we required that a given functional connection exhibit at least one nominally significant behavioral correlation ( p < .05) across all folds of the inner loop.

As an exploratory study, we also indicated associations that are nominally significant with a P-value <0.05.

Five of the 19 SNPs demonstrated a nominally significant association with neovascular AMD (P < 0.05), of which two (rs3173798 and rs3211883) withstood Bonferroni correction for multiple testing (rs3173798, nominal P = 9.96 × 10−4, allele-specific odds ratio = 0.55; rs3211883, nominal P = 2.09 × 10−4, allele-specific odds ratio = 0.50).

The differences in allele and genotype frequencies between ALL cases and controls were nominally significant (P < 0.05) for 20 SNPs.

The enrichment for the nominally significant association ( p < 0.05) was evaluated by a 10,000‐permutation test.

In subsequent analyses stratified by genotype, we observed nominally significant associations in both homozygous major and homozygous minor allele carriers ( p < 0.05).

Putative biological impact of differentially methylated genes The DMPs above the inflection point ( p < 0.002; n = 82; Table S 2 ) and nominally significant DMPs ( p < 0.05; n = 1957) were physically and functionally mapped to 66 and 1260 genes, respectively.

Among complete blood count, red cell distribution width, PLT, and PCT showed nominally significant pre–post differences ( P < .05).

1 Of the 208 unique genes associated with muscle strength in the meta-analysis all were significant in FHS alone (nominal P < 0.05), and 79 (38%) were also “independently” associated with muscle strength in the Illumina meta-analysis (nominally significant, P < 0.05).

However, nominally significant ( p < 0.05) associations were found for 15 pairs, 14 of which involved small or very small VLDLs and CpG sites in either SREBF1 or CPT1A .

To reduce the multiple testing burden, candidate TFs were tested for interaction with a given gene only if their marginal association with the target probe set was nominally significant ( p <0.05).

On each iteration, gene sets that were no longer nominally significant (unadjusted p ≥ .05) were excluded.

Larger magnitude nominally significant (p<0.05) genetic correlations were also found with depression-related phenotypes (range of r g 0.46–0.52), self-reported osteoarthritis ( r g = 0.63), and ICD-10-defined osteoarthritis ( r g = 0.49) phenotypes.

Of these 20 metabolites, only five showed nominally significant univariate differences between ME/CFS cases and controls (indole-3-propionic acid, aminomalonate, ornithine, leucine, and succinic acid; all p < 0.05), while the majority—including proline and indole-3-lactate, the constituents of the top-ranked interaction term—did not reach univariate significance in isolation ( p = 0.777 and p = 0.237, respectively).

While only nominally significant at p < 0.05, there was preliminary indication of differential methylation of genes involved in GTPase activity (GO ID:0090630) and cell-cell adhesion (GO ID:0098609) (See Supplementary material).