“nominally significant”

In eyes with serous PED at baseline, faricimab resulted in a greater decrease in maximum PED thickness throughout head-to-head dosing compared with aflibercept ( Fig 1 B), with nominally significant differences (nominal P < 0.05) at weeks 4 and 12.

The resulting nominally significant genes ( p ‐value ≤ 0.05 and absolute log2FC ≥ 3) were clustered based on their expression patterns using degPatterns from the DEGreport package (v 1.32.0).

Log scale metabolites for GDM and CON were summarized as means ± SDs with differences nominally significant at P < 0.05 since the metabolites had a normal distribution on the log scale.

Nominally significant associations ( p < 0.05) were observed between higher maternal levels of IL-8 during early pregnancy with lower gross motor (β: −0.902, 95%CI: −1.697, −0.107, p = 0.026) and fine motor (β: −0.880, 95%CI: −1.500, −0.259, p = 0.006) skills score at age one.

Results Fourteen of 34 SNPs showed a nominally significant association ( p < 0.05) with at least one diagnostic group.

Moreover, a nominally significant association threshold ( p < .05) was set in the replication stage to ensure that the overall significant association is robust across populations.

However, there are over 200 nominally significant between-breed genetic correlations but less than 50 phenotypic correlations compared with an expected error of 20 at p < 0.05.

Moreover, we identified 834 variant-trait associations primarily driven by the inclusion of participants from non-EUR populations; these associations were not even nominally significant in the EUR group (P > 0.05, table S9 ).

Through Model 1, there was a tendency towards a positive association between birth weight PGS and plasma levels of 5 proteins FABP2 (fatty acid-binding protein, intestinal), LPL, TNF (tumour necrosis factor), TNFB (TNF beta), GIF (gastric intrinsic factor) and a negative association with 3 proteins PRSS8 (prostasin), KIM1 (hepatitis A virus cellular receptor 1), and AMBP (protein AMBP), which were nominally significant ( P < 0.05) ( Fig. 3 b; Supplementary Table S10 ).

After false discovery rate ( FDR ) correction, pathway enrichment analyses for genes harboring nominally significant ( p < 0.05) probes identified 44 significant pathways ( q < 0.05), and 5 pathways were related to lipid metabolism.

No significant or nominally significant (P < 0.05) associations with glucose or insulin traits including fasting or 2 hour glucose and insulin from the OGTT, Insulin AUC, Glucose AUC, Matsuda Index or HOMA-IR were found for any of the SNPs in the Amish after adjustment for age and sex.

Nominally significant differences ( P < 0.05) were deemed ‘transgene-altered’ correlations.

3.4 Multivariate regression to maximize the association with subjective cognitive decline scores All variables which were nominally significant (p < 0.05) in the competitive model analysis, in addition to covariates, were then selected as input variables in a backwards stepwise multiple regression analysis to maximize the R adj 2 value ( Fig. 3 A ).

Separately, an excess significance test was conducted using the χ 2 test to investigate whether the observed number of studies with nominally significant results (O;”positive” studies, P < 0.05) differed from the expected number of significant results (E).

In unadjusted analyses, 26 SNPs from nine loci were associated with TC, 22 SNPs from 10 loci with LDL, 58 SNPs from 13 loci with HDL, and 40 SNPs from 14 loci with logTG at the nominally significant level ( P < 0.05).

Many of our networks had nominally significant (p < 0.05) overlaps with the cell-type-specific DEGs in neuronal cell types, which include both upper and deep layer excitatory neurons and inhibitory interneurons ( Figure 3 C and Table S12 ).

Causal estimates produced by the different methods had consistent direction of effect compared to the IVW estimate and all save MR-Egger were nominally significant (i.e. p < 0.05).

The majority of associations were nominally significant (raw P <0.05), and many also remained FDR significant.

A confirmatory look at candidates previously proposed to be involved in ECT mechanisms found CpG sites associated with response only at the nominally significant level ( p < 0.05).

The levels of all proteins (regardless of storage-time) with nominally significant ( p < 0.05) contributions were subsequently adjusted for age and/or plasma/serum by removing the contribution using the beta (β)-coefficient(s) from the linear models.

Therefore, only nominally significant (unadjusted p -value <0.05) rG are reported in the figure.

Sentinel variants (defined as the variant in an association signal where no other variants within 1 Mb showed a stronger association) of the novel signals reaching genome-wide significance in the meta-analysis ( P < 5 × 10 −8 ), and nominally significant ( P < 0.05) with consistent direction of effect in each study, were further tested in the replication samples.

Moreover, sensitivity gene-burden tests considering only those additional carriers identified by WGS (that is, not identified by WES data), 16 of the 23 gene masks with at least five carriers showed a nominally significant association ( P < 0.05) with the target phenotype, indicating that the additional coding variants identified by WGS are likely to be functionally relevant.

Regarding descriptive statistics on rumination, gender, age, lifetime psychiatric problems, and present somatic disorders, Supplementary Table 1 shows that except for frequency of pain problems there are differences between the Budapest and Manchester subsamples in all variables at either a nominally significant ( p ≤ 0.05) or trend (0.05 < p ≤ 0.10) level.

All discovery SNP-CpG associations ( n = 497,689) were nominally significant at baseline ( P < 0.05), and 99.5% ( n = 497,443) were nominally significant during the course of the disease ( P < 0.05).