“showed a trend”

183 TWIST1 silencing in an in vivo xenograft model showed decreased metastatic burden, and regardless of metastasis status in patients, positive expression of TWIST1 showed a trend toward lower survival. 183 Another recent discovery was the oncogenic potential of KDM3A , a histone demethylase, in ES. 184 KDM3A silencing in vitro showed a 50% decrease in migration and invasion and a tenfold decrease in metastatic burden compared to controls (in mice). 184 MCAM , which is also involved in metastasis in other cancers, is a direct downstream target of KDM3A , and when silenced, recapitulated impaired proliferation and metastasis are observed with KDM3A silencing.

MPNSTs with aberrant ATRX expression showed a trend toward worse OS in comparison to MPNSTs with retained ATRX expression, though statistically not significant (Figure 4A , p = 0.2091, log rank test).

1 ), and CCA IMT showed a trend toward a significant decrease.

Visual evoked potential-VEP and median nerve SEP (N13-N20) also showed a trend of stabilization or amelioration of latencies over time in treatment groups, although these differences didn ́t reach statistically significance over the time, as well as between groups;(p.F = 0,59; p.kW = 0,89).

No significant differences were seen between the methods for DNA library yield, neither for the libraries before capturing nor the final libraries, although the QIAGEN methods showed a trend towards more yield (Tables 3 and S1 ).

In in vivo studies, the changes of Asp levels in the five brain regions of rats during the process of anaesthesia showed a trend of a decrease followed by an increase, suggesting that xylazine may inhibit Asp synthesis and release, reducing excitatory neurotransmitter and receptor binding, ultimately reducing the excitability of neurons and producing anaesthetic effects.

In a hamster model of idiopathic paroxysmal dystonia, the higher dose of CBD showed a trend to delay the progression of dystonia (Richter and Loscher, 2002 ).

The results showed a trend for reduction in the incidence of primary CV outcomes in metformin-treated patients contrasting with a trend for an increase in MACE in patients not receiving metformin. 73 As the between-group was statistically significant, it was considered that metformin may act as a CV moderator of DPP-4 inhibitors, but obviously these hypothesis-generating findings require further confirmation. 74 Indeed, possible bias could not be excluded, especially because a major reason for not prescribing metformin may have been CKD, a condition known to be associated with higher CV risk as already mentioned.

In CMM, there was also significantly greater pS6+/S6+ cell density in the Trained-Novel group compared to the Trained-Familiar group (CMM: P = 2.26E −5 ; NCM: P = 0.42); NCM showed a trend for Trained-Familiar mTOR activation levels to be intermediate between those of both the Trained-Silence and Trained-Novel conditions (mean ± SEM: Trained-Silence: 0.061 ± 0.01; Trained-Familiar: 0.18 ± 0.024; Trained-Novel: 0.24 ± 0.035).

Following a 4-second optic nerve crush, intranasal ST266 increased RGC survival and showed a trend toward reduced RGC axon and myelin damage.

However, patients treated with Ada showed a trend towards more activated T cells (median 26.5%, IQR 14.4–33.6% for CD4 + and median 12.5%, IQR 6.9–18.3% for CD8 + ) as compared to those treated with Eta (median 14.6%, IQR 7–27.2% for CD4 + and median 4.8%, IQR 2.5–13.9% for CD8 + ) (p = 0.16 for CD4 + and p = 0.25 for CD8 + ; Fig. 2c ).

The c parameter increased in a linear manner with increasing E -field, whereas the a parameter decreased straightforwardly, but also showed a trend toward saturation at higher E -fields.

Pristanoyl-LPC(19:0) levels showed a trend to correlate with total pristanic acid levels as determined by GC-MS.

3 ), but showed a trend to increase by up to 5 mmHg in vasoconstrictors (Fig. 3 ).

Pigs vaccinated with B 2 T showed a trend towards increased levels of specific IgG1 and IgG2 relative to pigs vaccinated with B 4 T.

Overall, the rNIC showed a trend similar to the CIE a* values in current study.

59 A recent review of 11 articles looking at the topic of hysteropreservation during prolapse surgery showed a trend towards higher success rates and lower reoperation rates in patients with concomitant hysterectomy.

The repressive effects of the ligands were not significant on the regulatory regions near repressed genes, but they showed a trend towards repressed RNAPII-pS2 binding (Figure 6B and Supplementary Figure S6A ).

In the previously published study by Langan et al., increased expression of the ALDH1A1 protein showed a trend towards decreased patient survival, but this relationship did not show statistical significance (P=0.16) [ 13 ].

The inhibition effect of RT on overall GWP showed a trend that increase with tillage duration.

The basal spikelets showed a trend of increase in expression of CDKs and CYCs from 6 to 12 DAA upon cytokinin treatment in contrast to the apical spikelets.

Interestingly, in a subgroup analysis, abciximab showed even more benefit over tirofiban in patients with acute coronary syndromes, whereas tirofiban showed a trend towards a better outcome in patients without acute coronary syndromes [ 106 ].

“pC4W”) increased only in animals that received combination of plasmids while delivery of each growth factor alone showed a trend to increase compared to “pC4W” negative control ( Fig 2B , middle graph) without statistical significance.

The allele frequency of VEGFR-2 rs2305948T and of VEGF-A rs2010963C showed a trend of higher frequency than in general population (12.1% vs. 8.0% and 34.5% vs. 31.2%, respectively).

MitoQ and Nac, when administered alone, showed a trend similar to the untreated condition in both timings (12 h: MitoQ: 117 ± 19.81; Nac: 99.33 ± 5.16; Untr: 100.1 ± 10.47; ns) (48 h: MitoQ: 105.1 ± 13.48; Nac: 93.67 ± 12.53; Untr: 100 ± 10.01; ns) ( Figure 2 B,C).