“showed a trend”

Development of domagrozumab was discontinued despite the fact that treated participants showed a trend of increasing muscle mass volume, assessed by MRI, and improvement on the North Star Ambulatory Assessment (NSAA) score ( Wagner et al., 2020 ).

Treatment with increasing concentration of LanC under ER stress showed a trend of moderate suppression of GRP94 expression level and higher doses of LanC (0.75μM and 1μM) significantly inhibited GRP94 protein level ( Fig. 4 B).

Concerning VEP repeatability over time, CoVw and RSEw were comparable between the two anaesthetic regimens for amplitude and latency, with the latter that showed a trend in favour of sevoflurane, especially for the P2 component, probably due to the different pharmacokinetics of volatile versus injectable agents.

Though not approaching statistical significance, Slc39a2 knockdown showed a trend to enhance the PE-induced STAT3 phosphorylation, P65 phosphorylation, and IκBα expression ( Figures 6A–D ).

Children with recent exposure to SARS-CoV-2 showed a trend toward a lower incidence of acute kidney injury, fewer organ dysfunctions, and a lower frequency of invasive ventilation.

The patient’s blood routine examination after antibiotic treatment on day 1 of admission showed a trend of continuous deterioration; cooling treatment and antibiotics treatment were also ineffective.

After a phase II trial showed a trend for superior PFS for Adagloxad simolenin (AS)/OBI-821 compared to placebo in patients with Globo-H-high BC, the GLORIA study was initiated [ 101 ].

In the embryonic cell line HEK293T, svn-dEX3 and svn-2B showed a trend toward preferential PM translocation compared to svn-wt, despite equivalent expression levels ( Fig. 1 B).

also showed a trend toward increased mortality in primary ARDS compared to secondary ARDS in their studies. 20 , 21 Other factors which showed a trend toward poor outcome in our study, include high Murray score and low P/F ratio prior to initiation of ECMO support.

Our results also showed a trend (without reaching statistical significance), whereby the mean choroidal thickness measures for the test eyes were thicker than the control eyes after the defocus sessions.

Osteoclasts cultured on cartilage secreted active MMP8 and MMP9 and siRNA-mediated inhibition of either MMP showed a trend towards reduced GAG release from cartilage by osteoclasts.

In contrast, the constructs with both the poly-E motif and the TLDc domain, Ncoa7 (751–943), Ncoa7 (593–943) and Tldc2 (2–212), showed a trend toward stronger interactions with the V-ATPase in comparison with the TLDc domain-only constructs, Ncoa7 (775–943) and Tldc2 (44–212) (Fig. 5 B,C).

While the area under the curve for joint angles (hip-knee and knee-knee) showed a trend toward a decrease with stimulation on vs off; these changes were not significant (Fig. 3 D), perhaps, because the overall angular excursions remained the same (Fig. 3 A).

Residents who were involved in this study showed a trend of mistaking partial-thickness rotator cuff tears for normal or full-thickness rotator cuff tears, which is similar to the results of a study by Murphy et al. 24) The mistaken identification of a partial-thickness tear as either normal or as a full-thickness tear led to decreased diagnostic accuracy in US examination among novice examiners in our study.

One study using objective measures of physical activity (hip‐based accelerometry) showed a trend for increased serum 25(OH)D at higher physical activity levels (Klenk et al . 2015 ).

However, these analyses showed a trend to increasing resource utilization over the follow-up period of this study.

Motor function (UPDRS Part III ON) also showed a trend toward improvement.

In Tlr2 -/- mutant mice infected with PDIM-mutant Mtb, infiltrates showed a trend toward more numerous and larger areas of involvement than was observed in C57BL/6J mice ( Figure 7—figure supplement 1B–C ).

Autosomal dominant polycystic kidney disease (ADPKD) patients with truncating PKD1 variants showed a trend towards a greater slope of the age-estimated glomerular filtration rate (eGFR) regression line than patients with (i) missense variants, (ii) any PKD2 mutations and (iii) no detected mutations, according to previous findings.

Although we failed to demonstrate the cardioprotection afforded by BMSCs, irisin showed a trend toward improvement when compared with DMEM.

Cognitive profile, represented by CERAD (word list), word fluency test, and delayed recall test, too showed a trend to decrease with increasing severity of dementia.

PDAC cells treated with CM from IL-17RB OE PSCs showed a trend towards increased OCR compared with control CM and a significant increase of the OCR compared with naive tumor cells ( Figure 5 A).

Of note, the use of HIPEC showed a trend in improving survival of these patients, even if a statistical significance was not reached.

Although the triple combination showed a trend toward a lower SBP than the control treatment, it was not statistically significant (MD = −1.23 mmHg; 95% CI = −4.83 to 2.38; P fixed-effects model = 0.50; I 2 = 0%, P heterogeneity = 0.65) ( Fig 9 ).

It is also of interest that while they did not reach significance, all genes (with the exception of ARO8 ) involved in Lys biosynthesis showed a trend for decreased expression in long-lived strains ( Supplementary file 2 ).