Results of the AST reveal that Tg mice performed significantly better than Wt mice on the compound discrimination reversal (CDR) phase (p = 0.01) ( Figure 6 A); they also showed a trend for improved performance on the simple discrimination (SD) phase (p = 0.06) and on the intradimensional reversal (IDR) phase (p = 0.08) ( Figure 6 A).
After adjusting by age, route of HIV infection, length of infection before cART and viral hepatitis coinfection, CCR2 rs1799864-AG genotype was significantly associated with INR status (OR [95% CI]: 1.80 [1.04–3.11]; p = 0.04), and CXCL12 rs1801157-TT genotype showed a trend (OR [95% CI]: 2.47 [0.96–6.35]; p = 0.06).
Age showed a trend to an independent prognostic factor as well (p = 0.06): Fig 4 .
The level of IL-1β showed a trend to be higher in the DMPA users when compared with the no HC users (median log 10 transformed: 0.15 vs. −0.4; p = .06).
Univariate and multivariate analyses showed that ZNF703 amplification was an independent prognostic factor ( Table S10 ), while RPS6KB1 amplification showed a trend towards predicting worse BCSS independently (P=0.060).
Lower lung function was associated with the male gender and longer duration of asthma (OR 3.9 and 5.1, respectively) and showed a trend for the association with nasal polyps (OR 2.9, p = 0.06).
Patients with high-level IL-6 plus PTGER2 plus PTGER4 showed a trend to reduced distant metastasis-free survival (DMSF, p < 0.06 , Fig. 7 d), and a significant reduction in OS ( p = 0.0045 , Fig. 7 e), compared to patients with low-level IL-6 plus PTGER2 plus PTGER4.
The results showed a trend towards reduced lipid peroxidation (3.5±2.4% vs 5.6±3.7%, p = 0.06, HMGB1 vs control) while superoxide production was significantly reduced in the HMGB1 group compared with control (219±32 units/mm 2 vs 1185±97 units/mm 2 , respectively, p<0.0001) ( Fig 8 ).
Regarding patients with BN, those with comorbid anxiety disorders showed a trend towards a higher caloric intake during the episode (2612.3 [SD = 1478.1] vs. 1929.9 [SD = 1143.6], p = 0.060 Kcal with a moderate effect size (0.51) ( Table 3 ).
Emotion regulation showed a significant indirect effect (β=.13; P =.009), whereas coping self-efficacy showed a trend (β=.07; P =.06).
Notably, GGT showed a trend favoring SGLT2i with a borderline p-value ( P = 0.06 in the anti-diabetic drug subgroup), while FBG reduction lacked statistical significance.
ERD showed a trend towards an association with mortality (adjusted HR = 2.22; 95% CI = 0.96 to 5.14; P = 0.06; additionally adjusted for age, and rebleed).
A 2017 meta-analysis by Kim et al [ 28 ] found that second-line targeted therapy, such as regorafenib, significantly improved progression time ( P < .0001) and showed a trend towards improved OS ( P = .06).
After heat stress, the abundance of p_Firmicutes decreased significantly ( P < 0.05), and the abundance of p_Bacteroidetes showed a trend of increase ( P = 0.06), while the administration of SB effectively mitigated these changes ( Fig. 4 F-G).
Nevertheless, total bilirubin showed a trend for better recovery after the ingestion of supplement C compared to placebo ( P = 0.06).
In Cox proportional hazards models, high biomarker levels showed a trend toward conferring a higher risk of “not getting off treatment” as compared to low biomarker levels (for Gal‐9, hazard ratio [HR] 0.32, P = 0.06; for TNFRII, HR 0.24, P = 0.08; for CXCL10, HR 0.39, P = 0.1; for Gal‐1, HR 0.41, P = 0.1).
The use of veteran transportation services showed a trend to decrease the rates of no-shows without reaching statistical significance (7% vs. 14.5%, p = 0.06).
Post hoc comparisons for the main effect of treatment showed a trend for a reduction in GluN2B in CAST + testosterone compared to CAST mice ( p = 0.06) ( Figure 3(e) ).
Pre-DDAVP VWF showed a trend towards lower levels in excellent responders (Ag: P =0.06, Act: P =0.07).
Sixteen year-olds performed better than the12-year-olds (mean differences = 2.50, 95% CI [0.32, 4.69], p < 0.05), yet 15 year-olds showed a trend of outperforming the 12-year-olds (mean differences = 2.27, 95% CI [−0.050, 4.58], p = 0.06).
Finally, the stratified analysis according to the stage of melanoma revealed that PDE5i use was associated with a significantly increased risk for in situ melanoma (two studies, 16 , 20 adjusted RR =1.31, 95% CI =1.01–1.69, P =0.04, I 2 =69%; Figure 4B ), showed a trend toward increased risk for localized melanoma (three studies, 16 , 20 adjusted RR =1.13, 95% CI =0.99–1.29, P =0.06, I 2 =23%; Figure 4B ), and showed a trend toward reduced risk for nonlocalized melanoma (three studies, 16 , 20 adjusted RR =0.79, 95% CI =0.62–1.01, P =0.06, I 2 =0%; Figure 4B ).
In the mSDMT, group differences in accuracy and reaction time were non-significant, although pwMS showed a trend toward slower responses ( p = 0.06).
The group with dyslexia showed a trend for higher activity to symbol strings than print (average contrast estimates for Print > Rest: DYS = 1.72; Symbols > Rest: DYS = 2.15, p = 0.06, η 2 = 0.03, see Fig. 3 ).
However, L-arginine showed a trend for lower levels at ≤ 24 h ( p = 0.060) and 3 days ( p = 0.063).
Patients with fatigue (grades ≥3) showed a trend towards reduced survival (breast cancer-specific survival: HR = 1.17; 95 % CI, 0.99–1.37; P = 0.06).