Age showed a trend for association with individuals with both diseases (p = 0.00001; OR = 3.6, 95% C.I. 0.9-10.7) and chronic periodontitis alone (p = 0.002; OR = 3.0; 95% C.I. 0.8-10.52), suggesting that the difference in the distribution of BRINP3 alleles between healthy and individuals affected by peri-implantitis is confounded by the difference in the age of both groups (healthy individuals were on average 8 years younger than the affected individuals; Table 1 ).
Using rtCGM showed a trend towards a larger effect (MD −3.95 mmol/mol [−0.36 pp], 95% CI −5.46, −2.44 mmol/mol; p <0.00001) than using isCGM (MD −1.79 mmol/mol [−0.16 pp], 95% CI −5.28, 1.69 mmol/mol; p =0.31).
Males (0.249 ± 0.023, mean ± 95%CI) showed a trend towards higher BOLD activation than females (0.167 ± 0.028, p = 0.000012 by unpaired two-tailed t -test) when all nodes and subjects were assessed.
When applying a less restrictive threshold (nominal p -value < 10 −4 ), a second gene showed a trend of association: Neurocan (NCAN, p -value = 1.58 × 10 −5 ), as shown in Figure 4 .
Another correlated SNP in the same region (rs269101, r 2 = 0.42 in 1000 genomes phase3 Finnish individuals) showed a trend toward association in our GWAS ( p = 4.2 × 10 −5 ) and in the replicate ( p = 0.054), further supporting the result.
In this database, only one SNP (rs331142) in the ROBO1 gene showed a trend for association to ROBO1 expression ( p = 4.6 × 10 −5 ), but it did not reach genome-wide statistical significance (Tran et al. 2014 ).
In addition, although it was not statistically significant after correction of multiple comparison, rs2074262 showed a trend of association with mRNA expression of RAR related orphan receptor A (RORA, P = 0.00007) and somatostatin receptor 3 (SSTR3, P = 0.0001) gene in expression quatitative trait loci (eQTL) analysis using ENCODE dataset ( https://www.encodeproject.org ).
Odds ratios (ORs) for high SBP, high DBP and high BP were significantly greater in OW and OB children than NW group, and showed a trend increase correlating with obesity stages (all P <0.0001).
The A/California strain showed a trend characterized by two different peaks: the first in 2010/2011 (49.0%, 95% CI 39.0–59.0; p < 0.0001 vs. 2009/2010 for HI results) and the second one in 2014/2015 (53.0%, 95% CI 43.0–62.0; p = 0.004 vs. 2013/2014 for HI results).
This pattern was also true of the linear trend where this level of association was particularly apparent in relation to the high intensity angry expressions, such that the mean number of FRAXE repeats showed a trend - the more FRAXE repeats, the more likely was the boy to recognise extreme anger (P<0.0001).
The levels of IL-6, NF-κB, iNOS, and NGAL were significantly altered or showed a trend towards being altered by chronic noise and APP/PS1 overexpression (Fig. 5 a–d, ANOVA output: IL-6: exposure F (1,18) = 24.27, P = 0.0001, genotype F (1,18) = 0.5591, P = 0.4643, interaction F (1,18) = 0.005064, P = 0.9441, post hoc WT CON vs WT NOISE P = 0.0080 , WT CON vs APP/PS1 CON P = 0.9629 ,
Both backbone and IL7 coding virus-treated groups showed a trend for the reduction of tumor volumes, however IL7 coding virus-treated animals had notably smaller tumors than mock and Ad5/3-E2F-d24-treated animals ( p < .0001 and p = .0463, respectively) ( Figure 1h ).
Pelicans showed a trend (r 2 = 0.41, P<0.0001) toward earlier arrival between 1965 and 2008, with arrival dates advancing approximately 16 days ( Fig. 2 ; 21 April in 1965 vs. 5 April in 2008).
Correlation analysis showed a trend in increasing opening ICP with increasing ONSD, particularly when ONSD was >6.0 mm ( P < 0.0001, r = 0.40) [ Figure 2 ].
PF showed a trend toward increased IL‐1β (Figure 5K ), whereas SEMA induced a robust increase in IL‐6 ( p < 0.0001; Figure 5L ) and elevated TNF‐α compared to control ( p < 0.0001), though levels were significantly lower than in PF ( p < 0.0001).
HRD-positive PDACs showed a trend towards a higher mutation number (p < 0.0001), CNV burden (p = 0.0004) and SV number (p < 0.0001) per tumor when compared to HRD-negative PDACs.
Excluding coagulase-negative staphylococci, Enterobacterales was the most frequently isolated family (49% of the cases) for the period studied and this group showed a trend to increase along the years (p<0.0001).
CD73 − CD8 T cells from AML patients showed a trend of higher susceptibility to apoptosis manifested by significantly higher expression of CD95 expression ( P < 0.0001, Fig. 5 c).
Significant variation ( p < 0.05) in annual ceftolozane/tazobactam percent susceptible values was not observed for isolates from blood, intra-abdominal, and respiratory tract sources, while isolates from urine showed a trend of increasing ceftolozane/tazobactam susceptibility from 73.1% (2018, n = 145) to 90.6% (2023, n = 117) ( p < 0.0001).
After 5 days of aerobic exposure, WSCs showed a trend similar to that of day 0 ( p < 0.0001; 0.10, 0.13, 0.06, and 0.22 g/100g DM for MOL + HI, MOL, HI, and CTL, respectively) .
Results Immediately following the change to cascade reporting, FQ prescribing decreased by 38% (incidence rate ratio [IRR] 1.38; 95% confidence interval [CI] 0.50-0.77 p < 0.0001) and no change in trend was subsequently seen (IRR 1.01, 95% CI 0.98-1.04; p =0.59) (Figure 1).Cephalexin prescribing did not immediately change following the intervention (IRR 1.20, 95% CI 1.00-1.33; p =0.05) but subsequently showed a trend towards increase use (IRR 1.04, 95% CI 1.02-1.06; p < 0.0001) (Figure 1).
A generalized linear model, controlling for demographic and clinical characteristics and regimen, showed a trend toward higher total all‐cause cost PPPM as the number of incident AEs increased (cost ratio [CR] = 1.1, 95% CI 1.1‐1.2, P < .0001; Table S3 ).
solanacearum in the rhizosphere soil showed a trend of increased firstly and then decreased with the increase of soil pH (R 2 = 0.5569, P < 0.0001, Fig. 1A ).
Furthermore in the hanging wire grip test requiring strength and coordination the FE65/FE65L1-DKO mice had a significantly lower latency to fall compared to WT mice, while single KOs, which also showed a trend towards a lower latency to fall, were not significantly different from WT mice ( Fig. 1c , p = 0.0001).
3 ), health care use for schizophrenia disorders showed a trend increase across the pandemic (+ 2.92 per month; p < 0.0001) and a delayed start to increasing in the pandemic (− 18.31; p < 0.0001).