HER2 positivity showed a trend toward improved OS on multivariable analysis (HR 0.68, 95% CI 0.40–1.13; p = 0.138), though this did not retain statistical significance, likely due to the limited number of HER2-positive patients (n = 23).
The generalized HCR group showed a trend toward lower cumulative MACCE rates than did the OPCABG group (9.9% vs. 16.2%; HR, 0.567; 95% CL, 0.268–1.201; P = 0.138), but the differences were not statistically significant.
Multiple-injured patients with A-type spinal injuries showed a trend towards a lower overall injury severity compared to multiple-injured patients with B-/C-type spinal injuries (ISS: 22.75 vs. 26.36, respectively; p = 0.138).
Changes in the Expression of Inflammatory Pathway Proteins In the liver homogenates, we showed a trend toward an increase in the expression of NF-κβ at the end of the experiment (fifth week: p = 0.1380; Figure 5 A).
Patients with no less than 54.4ng/ml in AFP BL showed a trend with better RFS than those who did not ( p = 0.138, Supplemental Materials Figure 1D ).
Although ADC mean showed a trend toward higher values in responding lesions ( P = 0.1386), no statistically significant association was found.
The median age of participants in these trials ranged from 62 years to 78.5 years and showed a trend upwards over time ( p = 0.1388).
Additionally, a multivariable Cox regression analysis showed a trend toward association with poorer overall survival (HR = 1.695, 95% CI: 0.842–3.414, p = 0.139), with several individual genes such as RNF24 (HR = 1.887, CI: 1.378–2.583, P = 7.55 × 10 −5 ) and CEP170 (HR = 1.681, CI: 1.147–2.465, P = 7.55e × 10 −3 ) being independently associated with prognosis ( Figure 6D ).
Group B had a higher rate of aortic root replacement (44% vs 35%, P = .008), lower ascending aorta and hemiarch replacement (40% vs 53%, P = .013) and showed a trend towards more extensive distal aortic repairs: total arch replacement (27% vs 20%, P = .139) and frozen elephant trunk (20% vs 14%, P = .171).
In renal tumors, HNF1B positivity showed a trend towards increased thromboembolic events ( P = 0.14, two-tailed Fisher’s exact test) ( Table 1 ).
The group with stage IB1 tumors >2 cm had statistically deeper cervical stromal invasion (9.99±5.04 mm, p<0.001, Kruskal-Wallis test), higher incidences of LVSI (45.3%, p = 0.002, chi-square test), and greater lymph node metastasis (24.2%, p = 0.002, chi-square test) compared to the other 2 groups (stage IA2 and stage IB tumors ≤2 cm).The group with stage IB1 tumors >2 cm showed a trend toward a higher incidence of parametrial invasion (9.5%, p = 0.14, chi-square test) compared with the other two groups (stage IA2 tumor, 0%;stage IB1 tumor ≤2 cm, 4%), though it did not reach statistical significance.
Depression Before proton beam therapy, the study cohort had a mean depression score of 4.36 (CI 3.63–5.09) and showed a trend for improvement of depression to 3.67 (CI 2.93–4.41) at 2 years ( β = 0.693; SE = 0.47; p = .140; Table 2 ).
The low dosage (Low) group showed a trend of inhibitory effect on paw swelling when compared with the model group ( p = 0.14), as shown in Figure 1 B,C.
Social gathering restrictions were strongly positively correlated with percent at-risk for depression (r = 0.47, P = 4.3E-05) and poor subjective wellbeing (r = 0.56, P = 4.8E-07) but showed a trend toward negative correlation with anxiety (r = -0.18, P = 0.14), which was significant when Spring Break weeks were excluded (r = -0.26, P = 0.036).
While S1 showed a trend towards worse prognosis when compared to S2, this difference was not statistically significant in cox regression analysis ( p = 0.14).
In 37 patients with newly diagnosed ENKTL, low PET/CT scores (0–2) showed a trend for better overall ( P = 0.14) and progression free survival ( P = 0.34) compared to high scores (Supplementary Fig. 1 .
Amplitudes at this latency for correct and incorrect trials were reliably different for the II distribution ( F (1,11) = 6.3, p = 0.03, η p 2 = 0.37) and showed a trend in the opposite direction for the RB distribution ( F (1,11) = 2.6, p = 0.14, η p 2 = 0.19).
The results were similar when multiple imputation was performed (RR, 1.23; 95% CI, 0.80–1.88, P = 0.35). The frequency of treatment failure was significantly associated with TNM stage (Table 2 ) and showed a trend towards an association with tumour differentiation ( P = 0.14).
Transposon expression (p < 0.0001) was elevated, and intron retention showed a trend toward elevation (p = 0.14), in the liver of 26-month-old mice, suggesting these age-related transcriptional defects might be conserved between species ( Figure 1—figure supplement 4A, B ; Figure 1—figure supplement 5 ).
In a multivariate Cox regression model adjusted with age, gender and indication angiography, DM treated with insulin showed a trend as predictor for both MACE and TLF (HR 2.01; 95% CI 0.80–5.04; p = 0.14 and HR 2.54; 95% CI 0.93–6.97; p = 0.07 respectively), while absence of postdilatation showed a trend as predictor for TLF (HR 0.40; 95% CI 0.15–1.07; p = 0.07) as is presented in Table 4 .
Overall Gprc5b levels, determined with a primer set (A/a) that amplifies a region common to both Gprc5b_v1 and v2, showed a trend towards an increase on day 17 (1.8 fold; p = 0.14) after normalization to beta-actin levels ( Fig. 4A , 3 rd panel from top ).
Compared with CDH13 -unmethylated cancers, CDH13 -methylated cancers showed a trend towards preferentially invasive ( P =0.140) and short time alive ( P =0.167) in oesophageal cancers.
Interestingly, the proliferative ability of zamto-cel as assessed by CD27 and CD127/IL-7R expression showed a trend for increased expression in patients with CR (CAR + CD4 + CD27 + in CR [mean, 86.2; 95% CI, 73.57-91.59] vs non-CR [mean, 60.98; 95% CI, 8.93-92.14; P = .14], CAR + CD4 + CD127/IL-7R + in CR [mean, 82.09; 95% CI, 76.97-88.93] vs non-CR [mean, 59.34; 95% CI, 29.87-82.48; P = .035], CAR + CD8 + CD27 + in CR [mean, 88.85; 95% CI, 82.09-94.46] vs non-CR [mean, 66.33; 95% CI, 16.55-94.01; P = .05] and CAR + CD8 + CD127/IL-7R + in CR [mean, 26.72; 95% CI, 15.52-43.95] vs non-CR [mean, 12.36; 95% CI, 1.93-49.96; P = .1]; Figure 3 A-B; supplemental Figure 6 C).
The high/intermediate-TIL group showed a trend toward better DFS ( p = 0.14, Fig. 3 b) and significantly better OS ( p = 0.03, Fig. 3 d) than the low-TIL group by the average method, although analysis using the hot-spot data did not show any significant difference either in DFS or OS (Fig. 3 a, c).
In regions with low VEGFR2 expression, this difference was not significant but again showed a trend toward higher expression in HPV-negative tumors ( Figure 3 A; p = 0.140).