Barely Significant
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“showed a trend”

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In the literature

In post hoc analyses, sacubitril/valsartan showed a trend towards improved outcomes in patients who initiated treatment in proximity to the index hospitalisation or had an EF ≤57% and eGFR ≤45 mL/min/1.73 m 2 , although these findings remain exploratory and should be interpreted with caution. 75 76) Pooled analyses of PARADIGM-HF and PARAGON-HF, which included patients across the full EF spectrum, further support that the therapeutic effects of sacubitril/valsartan on HF hospitalisation vary by EF, with the greatest benefits observed in patients with EF below the normal range (approximately ≤55%). 77) Based on these findings, the U.S.
In comparison with our previous study, where BMI was stratified up to 29 kg/m 2 (Niinuma et al., 2025[ 31 ]), EGFR differed in both studies; fibroblast growth factor 8 (FGF8), FGFR1, IGF1 differed in the previous study and here they were either significantly different (IGF1, p=0.05) or showed a trend (FGF8, FGFR1) towards significance (0.06 and 0.07, respectively), but none remained significant after FDR testing.
23 24 In addition, a recent multicentre randomised controlled trial in cardiac surgery patients reported that perioperative liraglutide administration improved glycaemic control and showed a trend towards reduced POD incidence, although statistical significance was not achieved, possibly due to younger patient age, lower baseline surgical risk and a lower than expected delirium incidence in the control group. 25 Importantly, liraglutide was well tolerated, with no significant increase in gastrointestinal adverse events (AEs) compared with placebo.