“showed a trend”

Importantly, the only notable change in this RCT-only analysis was observed for minor bleeding events (BARC type 1).Whereas de-escalation was associated with a significantly lower risk of BARC 1 bleeding in the overall analysis (previously RR: 0.52, 95% CI: 0.32–0.86), the RCT-restricted analysis still showed a trend toward reduced minor bleeding with de-escalation but this difference was no longer statistically significant (RR: 0.65, 95% CI: 0.28–1.50, p = 0.311).This attenuation of significance is most likely due to the reduced sample size and statistical power after excluding the observational cohorts, rather than a true reversal of effect.Overall, the RCT-only sensitivity analysis confirms the robustness of our primary findings.

High frailty showed a trend toward delayed adjuvant initiation but did not reach statistical significance after multivariable adjustment (adjusted OR 0.14, 95% CI 0.02–1.35; p = 0.089) (Table 7 ).

The viral load showed a trend of increasing first and then decreasing, reaching a shedding peak at 9–11 dpi, with the maximum value up to 10 4.35 ± 10 0.67 PFU/mL (10 10.30 ± 10 0.37 copies/mL).

Consistent with this postulate, the ECC group showed a trend toward a higher temporal increase in APRI and FIB-4 at 7 years although these changes did not achieve statistical significance.

Similarly, older children showed a trend toward lower angulation in both planes at six-month follow-up, but the amount of correction was not statistically significant.

For food-related stimuli, the Group × Time interaction for LPP amplitude did not reach statistical significance but showed a trend in the same direction.

In the Cox regression model, HPV16 positivity showed a trend toward an increased hazard of progression to CIN3, although the estimate was imprecise and did not reach statistical significance ( p = 0.146) ( Table 2 ).

In sex-stratified analyses, among women, perceived stress showed a moderate negative correlation with sleep quality, weak negative correlations with age and total cholesterol, and a very low negative correlation trend toward 8-hydroxy-2′-deoxyguanosine; in addition, perceived stress correlated positively (very low) with platelet count and illicit drug use and showed a trend toward a positive correlation with morbidity count.

This observation may reflect a reduction in systemic inflammatory activity, as indicated by the hs-CRP/albumin ratio and NLR, which showed a trend toward post-treatment decreases.

Higher M2 TAMs infiltration was associated with deeper tumor invasion (pT) and showed a trend toward advanced pTNM stage.

The spirulina pretreatment showed a trend toward an improved lipid profile in the HFD + IR condition, where TC was significantly less prominent.

Second, higher levels of ubiquinone showed a trend towards an association with higher all-cause mortality risk, which reached statistical significance only in the unadjusted model.

Patients with a Sister Mary Joseph nodule showed a trend toward better survival outcomes.

Compared with MTAP wild-type tumors (median 63 years, IQR 55–69), patients with MTAP deletion showed a trend toward older age; however, this difference did not reach statistical significance (Wilcoxon rank-sum test, p = 0.069).

In a prespecified exploratory analysis of the CD16A-158 polymorphism (V, high-affinity; F, low-affinity), patients with the CD16A-158FF genotype showed a trend toward improved OS with margetuximab compared with trastuzumab (median, 23.6 vs. 19.2 months; HR, 0.72; 95% CI, 0.52–1.00).

In groups 6–9 and 10–13, as fiber content increased, N 1 and N 2 showed a trend of initial increase followed by a decrease.

In the ordination plot, samples from Group C and Group M showed a trend of differential distribution along the coordinate axes.

As shown in Figure 2 , as the initiator amount increased, the gelation time of the supramolecular gel gradually shortened, while the viscosity showed a trend of first increasing and then decreasing.

Tumor-related factors: Tumor ulceration and necrosis showed a trend toward worse survival but did not reach statistical significance (HR = 0.52 for absence vs. presence; 95% CI: 0.23–1.16 and p = 0.112).

Paired comparisons showed a trend toward lower thresholds with CE-Chirp, although statistical significance was not reached due to the limited sample size.

Mice treated with resveratrol showed a trend toward increased time and distance on the rotarod compared to the D-gal-induced aging mice ( Figure 1 L,M).

Results The trial (N = 260) showed a trend towards fewer major renal or cardiovascular events in the integrated care group, particularly fewer heart failure hospitalisations.

In the FLT3 m subgroup ( n = 66), oral azacitidine improved relapse-free survival (RFS) and showed a trend toward improved OS [ 15 ].

Among the variables included in the model, nitrous oxide use showed a trend toward association with anxiety reduction.

The cooking loss of the samples showed a trend analogous to that of drip loss ( Figure 4 B).