Barely Significant
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“showed a trend”

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In the literature

Preliminary studies showed a trend towards weaker response to interferon mono-therapy in the presence of occult HBV.[ 2 , 33 ] However, these were followed by several studies which differed in their views and emphasized a minimal role for occult HBV in occult contamination in response to interferon mono-therapy or its combination with ribavirin.[ 28 , 40 – 43 , 45 ] Due to the differing results obtained in various studies, and the absence of prospective controlled trials, it becomes imperative to perform such trials to clarify the role of occult HBV infection and its impact on anti-HCV treatment.
Nevertheless, cancer genes tend to expand across large genomic regions [30] , and examination of eight genes likely involved in breast cancer through low-penetrance mutations– CASP8 , COX11 , ESR1 , FGFR2 , LSP1 , MAP3K1 , RAD51L1 and TOX3 [2] – [6] , [13] , [14] –showed a trend for larger genomic loci (mean ( ) genomic extension = 211 kilo bases (kb) and standard deviation (σ) = 283 kb; compared to = 66 kb and σ = 128 kb for all annotated genes in the CGEMS GWAS rank).
59 Elderly patients treated in the pooled randomised trials showed a trend towards better adjusted outcomes (score on modified Rankin scale 0-2 v 3-6) than those who did nor receive thrombolysis (1.8, 0.73 to 4.3; n=137). 59 Previous studies have shown findings consistent with our results but on small datasets. 20 58 60 61 62 63 64 Despite these points, treatment allocation in our study was not randomised.
The PP analysis showed a trend of reduced risk of LBW, severe anaemia and premature delivery in the SP3 group, albeit the difference between two and three IPTp-SP did not reach statistical significance.