However, Young’s modulus of OHCs actually showed a trend towards increased stiffness in hypothyroid conditions between E16 and P3 (Figure 5 B) with this difference becoming statistically significant at P3 (p-value < 0.05).
Notably, the thermal hypersensitivity showed a trend to recover over weeks 2 to 4 (slope: 0.21 ± 0.02, t-value: 7.94, p < 0.05); see also the changes expressed as the MPE ( Figure S4A in Supplementary Materials ).
In Met, LoDG and MetDG compared to CTRL, hexose showed a trend towards lower levels ( p > 0.05, Fig. 5 ).
Catalase ( cat ) genes of LMB sperm showed a trend of decreasing and then increasing under low temperature, reaching a minimum value in May ( p < 0.05) and then increasing, reaching a maximum value in August ( p < 0.05) ( Figure 7 C).
Despite this, relative abundance comparisons of individual microbes at the ASV level showed a trend towards increased abundance ( P <0.05, P FDR = 0.74; Supplementary Table 2 ) of Bacteroides vulgatus , Holdemanella biformis and Lachnospiraceae spp. in the fecal microbiome ( Supplementary Figure 2C ).
Analysis of our data did not reveal a statistically significant association between physical or mental multimorbidity and rates of irreversible organ damage (SDI ≥ 1), although the total number of physical comorbidities showed a trend for correlation with the SDI (Spearman’s rho = 0.126, p = 0.050).
From the cleaved PARP level, although with a high variation, 20 μM carvedilol showed a trend of reducing UV-induced apoptosis in the 3D culture ( Figure 5 C) ( p > 0.05).
Furthermore, ITGB4 high patients showed a trend toward poorer survival (log-rank p < 0.05, Figure 4C ).
Additionally, it showed a trend-level positive correlation with defecation difficulty (r = 0.19, p = 0.05), and a trend toward a negative correlation with solid stool leakage (r = −0.19, p = 0.05).
Conversely, D -Fructose concentrations showed a trend towards higher levels in the glucose-loaded group compared to the non-loaded group ( p = 0.05) (Fig. 3B ).
3C ) showed a trend toward increased tau 4R expression (exon inclusion) in 2-month-old ADNP+/− mice compared to ADNP+/+ controls ( p <0.05, one tail, t-test comparing only tau 4R expression), which disappeared in older, 9-month-old mice, showing similar tau species expression in the ADNP+/+ and ADNP+/− mice ( Fig. 3C ).
We identified 449 transcripts that showed a trend with age (adjusted p-value < 0.05) of which 426 show increasing expression with age and only 23 are decreasing.
Transcriptomic analysis showed that 48 steroidogenesis pathway genes in the livers of HC mice exhibited significant expression changes ( p < 0.05), and 42 of these genes showed a trend of reversal after GP treatment, with 32 genes being significantly reversed ( p < 0.05).
Interestingly, two SNPs ( SORT1 /rs602633, UBE2Z /rs46522) including the one that showed a trend of association in the additive model became significant ( p < 0.05) and two ( COL4A1-COL4A2 /rs4773144, CYP17A1-CNNM2-NT5C2 /rs12413409) showed a trend of association ( p < 0.10) ( Table 3 ).
Reference men with b2/b4 duplication compared to subjects with no AZFc rearrangements showed a trend for lower follicle-stimulating hormone (FSH) (median 2.3 [5–95% range 1.4–7.5] vs 3.2 [1.3–7.1] IU/l; p<0.05) and luteinizing hormone (LH) (3.1 [1.7–5.0] vs 3.8 (1.7–7.2) IU/l; p<0.05).
The low-dose resveratrol treatment (20 mg/kg) also showed a trend towards reducing LDH levels in diabetic rats, although the difference between two dosages did not reach statistical significance ( p > 0.05).
Urinary Hg showed a trend of decrease ( p < 0.05) with increasing pre-pregnancy BMI.
Notably, the Streptococcus genus had higher mean relative abundance (not significant) in PacBio than in Illumina platform in saliva and subgingival plaque biofilm samples whereas other relevant genera known to be oral pathogens like Fusobacterium, Leptotrichia and Treponema showed a trend for lower relative abundance ( p < 0.05, adjusted p -value > 0.05) (Fig. 3 ).
Lesions with positive HU showed a trend toward a prevalent spine distribution as compared to those with negative HU (60% vs 38%, respectively ( p < 0.05), whereas lesions with negative HU were more represented at the site of pelvis, although not significantly (45% vs 26%, p = 0.067).
Vice versa, after 8 weeks, cardiac masses, volumes, and output showed a trend for lower values in sham operated rats compared to controls in absolute measures (782.2±57.2/260.2±33.2 vs. 805.9±84.8/310.4±48.5 mg, p<0.05 for left/right ventricular mass), but not normalized to body weight.
Overall treatment time (OTT) ≥45 days showed a trend for a lower PFS ( p = 0.050) and was significantly associated with lower EFS ( p = 0.030) and histological grade 3 with a lower LC ( p = 0.025).
No significant differences were noted in the UPDRS III motor scores, even though women showed a trend towards having worse bradykinesia ( P = 0.05) and axial motor ( P = 0.07) scores compared to men during ON.
Moreover, patients with incident spine fractures during follow-up interval showed a trend towards lower VD L1–3 (143.48 HU ± 46.16 HU) compared with patients without incident spine fractures (187.42 HU ± 57.16) ( P = 0.05).
Overall, although postoperative Qmax and IPSS showed a trend toward better outcomes in the F21 group, these differences did not reach statistical significance ( p > 0.05).
With the increase of Phe level, the contents of valine (Val), arginine (Arg), and histidine (His) all showed a trend of first decreasing and then increasing, and all reached the minimum at 7.51 g/kg Phe level ( P < 0.05).