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showed a trend

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showed a trendP = 0.0501.0× alpha
Overall, the results did not reveal statistically significant associations in any of the tested models, with the marginal exception of SNP rs743572 ( CYP17A1 ) under the dominant model, which showed a trend toward association (OR = 1.56; 95% CI: 1.00–2.45; P = 0.050), despite moderate heterogeneity ( I 2 = 55.6%).
6 variants, 1 located in the signal peptide (p.M1I), and 5 non-synonymous variants (p.A36T, p.Y57C, p.W69R, p.R101Q, p.I169T) showed a trend towards reduced responses to IL-10 stimulation, but these differences did not reach statistical significance of p < 0.05 in the HEK293 cell system (Fig. 2A ; Supplementary Fig. 3A ).