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showed a trend

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showed a trendP = 0.0531.1× alpha
Unadjusted analyses using the median cut point showed that the low HIF1α expression was significantly associated with better LRC [HR (95% CI) = 0.58 (0.38–0.89), P = 0.011] as well as OS [HR (95% CI) = 0.62 (0.42–0.91), P = 0.016], and showed a trend towards improved PFS [HR (95% CI) = 0.69 (0.47–1.01), P = 0.053, Fig. 2a–c ].