Barely Significant
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trending toward significance

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In the literature

Although only trending toward significance, likely due to the low number of patients in this subgroup analysis, these data suggest that there may be a clinically meaningful benefit from the IO score or the IO + /TMB high model (IO HR 0.3001, 95%CI 0.0773–1.165, p = 0.0819; IO + /TMB high HR 0.3432, 95%CI 0.09792–1.203, p = 0.0946) (Figure S2A).
The most significant GIF connections and network interactions in females involved VNs (dorsal and ventral stream, MT+ complex), medial temporal (trending toward significance; Table 2 ), lateral temporal, superior parietal, anterior cingulate, posterior cingulate ( high number of connections, although not significant in terms of relative density in Table 2 ) (Figures 2 and 3 , right panel; Table 2 ).
When stratified by QRS duration, women had a significant reduction in HF or mortality at all ranges of QRS duration, while men exhibited more benefit at ≥150 ms (although trending toward significance with QRS duration <150 ms). 9 , 128 A meta‐analysis 120 of 4076 patients from the RAFT, MADIT‐CRT, and REVERSE trials—comparing CRT‐D to ICD therapy in patients with predominantly NYHA class II HF—reported the sex‐specific benefit in HF or mortality in those with LBBB stratified by QRS durations in 10‐ms increments from 120 to ≥180 ms.
In a per-signature analysis, UPFL tumors were significantly enriched, as compared with UPPL tumors, for numerous subsets of T cells, including CD8 + , central memory, and effector memory, while trending toward significance for T follicular helper cells and γδ T cells (Bindea) ( Figure 4, C–G ), the latter of which are important for adaptive immunity at mucosal surfaces ( Figure 4G ).