Excerpts

A comparison of these results with a random walk model indicated highly significant differences between experiment and simulation.

A borderline non-significant association was reported between EVTF activity and VTE in patients with pancreatic cancer but not in patients with brain, stomach, and colorectal cancer [ 69 ].

Again, highly significant differences between the cell lines were seen ( Supplementary Figures S2 and S3 ).

Interestingly, although not reaching significance, we observed a clear trend showing that the presence of nNav1.5 had a negative impact on PFS when analysed in combination with all the other biomarkers.

Furthermore, by considering lymph node metastasis in the p53 aberrant GAC, a better prognostic stratification was achieved which finally allowed us to separate the GAC highly significant in a group with poor and good-to-intermediate prognosis, respectively.

In agreement with our result, a meta-analysis of 46 retrospective observational studies also demonstrated a borderline significant relationship between telomere length and overall prevalent cancer [ 48 ]. 4.1.2.

BLI tracking over the course of the experiment demonstrated that tumor load between the three groups started segregating around day 30, with maximal differences noted at about day 47, with the CAM1615HER2 TriKE demonstrating highly significant and superior tumor control ( Figure 6 C,D).

In advanced NSCLC patients, neither the tumor stage nor the grading were able to accurately identify cases at higher risk of early disease recurrence, although a slight trend toward statistical significance was obtained when grouping according to the tumor stage ( Supplementary Table S4 ).

Combined therapy with crizotinib+decitabine or crizotinib+trametinib resulted in a significantly higher inhibition of tumor growth compared to single treatments, while tumors treated with crizotinib+CHO showed a trend toward better inhibition compared to single drugs ( Figure 3 E). 3.4.

While many of the inflammatory cytokines assayed did not exhibit statistically significant differences, there was a notable trend for cytokine levels to be higher in the plasma of immunized mice.

Female CCSs who had received alkylating agents showed a decreasing trend in AMH levels.

Similarly, xCell showed significantly higher levels of CD8+ T cells in patients with pCR than in those with non-pCR; this difference was marginally significant according to CIBERSORT.

Interestingly, a strong association between G allele presence at MOR A118G and increased breast cancer incidence in females has been reported and is interpreted as a highly significant risk factor in breast cancer development [ 18 ].

We observed that the bioluminescent intensity of the tumor in the control group generally showed an increasing trend similar to that of the tumor volume ( Figure 6 A,C,D).

At 11 months post-DEN injection, LmiR21KO tend to have a higher liver weight than their control littermates (miR21fx—CTRL), while miR21KO mice display highly significant hepatomegaly ( Figure 2 A).

Despite a high variability between mice, inherent to these analytical methods, a positive trend for ERK1, p38, and JNK over-activation was observed in DEN-treated LmiR21KO or miR21KO mice as compared to CTRL mice ( Figure 4 C).

Similarly, β-catenin protein expression was also decreased in tumors of mice treated with the combination therapy ( Figure 4 I,J); however, this difference did not quite reach significance. β-catenin is involved in cell–cell adhesion through interaction with the E-cadherin cell-adhesion complex [ 44 ], and gastrin has been shown to increase metastases by inducing β-catenin nuclear translocation [ 45 ].

There was a clear trend between larger motion amplitudes and greater distances from the spine for lung, kidney, adrenal gland, and lymph node lesions, but not for hepatic lesions.

Among the highly significant differentially methylated position (DMP)-associated genes, we identified that the miR-33b gene is hypermethylated and may be involved in the dissemination of ovarian cancer cells in the omentum ( Figure 1 A).

Moreover, patients receiving AC showed a trend towards a higher tumor burden as reflected by higher LDH serum levels upon ICI initiation.

0; significant improvement in PFS2, and a strong trend of improved OS) [ 13 , 14 ].

Likewise, a systematic review and meta-analysis reported an increased risk of ovarian cancer with higher BMI, and a marginally significant positive association with WC, but no association with hip circumference or WHR [ 42 ].

The incidence showed a downward near-significant trend for the younger age group (<18 years) (AAPC: −3.1% (95%CI −6.4 to +0.2), whereas estimation of a reliable AAPC was not possible for the young adults due to the low incidence in this group ( Figure 2 C).

Notably, patients with a preoperative L3SMI above the 75th percentile (>40.0375 cm 2 /m 2 ) of all patients showed a clear trend toward improved postoperative overall survival, when compared to the other patients (1435 (95% CI: 0–3222) days vs. 473 (95% CI: 218–728) days and 403 (95% CI: 109–697) days; log rank X 2 (2) = 5.303, p = 0.071; Figure 4 B).

Somewhat in contrast to the overall series, female sex correlated with better survival and volumetric findings were of borderline significance i.e., a larger tumor load predicted an adverse prognosis.