Excerpts

Compared with the Huh7-LR-NC control group, the Huh7-LR-Sh group showed a trend toward a significantly decreased positive rate of Ki67 and a significantly increased positive rate of Caspase-3 ( Figure 4 H).

Both groups showed comparable survival patterns, with a slight trend toward reduced survival in WNT-altered patients at later follow-up, though this was not statistically significant.

All p -values are two-tailed, and significance was represented in p -values < 0.001 (*** highly significant), <0.01 (** very significant), <0.05 (* significant), and >0.05 ( ns non-significant). 3.

Cumulative reporting of individual DEs revealed an overall trend of increased DE reporting as the years progressed ( Figure 2 ).

For the time main effect, our result showed a decreasing trend of self-reported low energy score across 84 consecutive days, suggesting that the intervention may have contributed to improvements in perception of energy over time.

The study specifically examined records from the previous decade, providing a detailed review of trends and patterns between 2010 and 2019, and predicts that the incidence of GC is on a decreasing trend in the majority of countries, including high-incidence countries such as Japan (age-standardized rate (ASR): 36 in 2010 vs.

Similarly, the well-established adverse prognostic indicators of SRC histology, LVI, and PNI, all of which were highly significant in univariate analyses, did not retain independent predictive power for OS after adjustment for clinicopathological confounders, most notably pathological TNM.

While exposure to SCP showed a trend toward improved adherence, gaps remain in SCP implementation, especially regarding written follow-up instructions.

second-line between cannabis users and non-users resulted in: • Chi-square value (χ 2 ): 3.78 • p -value: 0.0518 • Degrees of freedom (dof): 1 • Expected frequencies: ○ First line: [26, 13] ○ Second line: [42, 21] The p -value of 0.0518 is very close to the 0.05 threshold, suggesting a borderline significance in the difference between cannabis users and non-users regarding whether immunotherapy was given as a first or second-line treatment.

A negative trend can be observed over time ( Figure 2 ) despite the increasing body of evidence in later years (2014–2024) compared to earlier periods (1995–2014).

[ 46 ] noted that higher BMI, particularly in obese patients (BMI ≥ 25 kg/m 2 ), was associated with a 25% lower risk of disease progression (HR = 0.75; 95% CI: 0.62–0.92), with a significant trend of decreasing progression risk with increasing BMI.

We found that mFOLFIRINOX was associated with significantly improved disease-free survival and a favorable trend toward better overall survival, independent of histological subtype.

Similarly, patients with low hemoglobin levels, below 12 g/dL, indicating anemia, also showed a trend toward earlier disease progression.

However, odds ratios were generally <1, indicating a possible trend toward lower response rates in frailer individuals, although these findings were not statistically significant ( p > 0.05).

On UVA, GTV ≥ 30 cm 3 ( p = 0.038), and PTV ≥ 150 cm 3 ( p = 0.010) were associated with an absolute drop in platelet count by ≥50,000/mm 3 within six weeks of SBRT, while prior focal liver treatment ( p = 0.097) showed a trend toward significance.

Underlying viral cirrhosis ( p = 0.033), A6 or higher pre-SBRT Child–Pugh score ( p = 0.010), and pre-SBRT platelet count <100,000/mm 3 ( p = 0.017) were significant for a rise in Child–Pugh score of 2 points or more, and the volume of liver-GTV <1000 cm 3 ( p = 0.093) approached significance.

Following initiation of therapy, both patient-reported and parent-reported outcomes showed a trend towards improvement and subsequently remained stable throughout the duration of treatment. 4.

For AML, there appeared to be a decreasing trend in risk with higher TREC levels suggested by the plot for California, whereas the trend for Texas was essentially flat.

A comparison of the Beta values representing methylation levels of all probes showed an overall trend of hypomethylation in DLBCL compared to control cases ( Figure 2 B), suggesting global methylation associated with DLBCL pathogenesis.

IM-type DR and the presence of lymph node metastasis showed a trend toward poorer OS, although they were not statistically significant in the multivariate model (HR: 1.744, p = 0.387; and HR: 2.057, p = 0.172, respectively). 4.

In one study, a DNA microanalysis of samples from adult AML patients showed a trend for high levels of PRAME mRNA to correlate with improved overall survival (OS) [ 8 ].

H&E staining of tumor sections and computational image analyses of tiles containing muscle, adipose cells, and blood vessels surrounded by cancer cells showed a clear trend of increased cancer cell invasion into the mesenchyme and muscle tissue in TSK mice, although it did not achieve statistical significance ( Figure 3 e,f).

>3 cm) had a trend towards significance.

Only the variant chr22:g.29695793:A>C, proximal to CHEK2, showed a numerical trend toward HRD enrichment.

Included studies showed a trend of increased reporting since the turn of the last decade, with 77% of included studies published after 2011 ( Table 1 ).