Excerpts

Fatigue measured with EORTC QLQ-C15-PAL had a borderline significant effect in men (−0.33 (95%CI −0.67 to 0.03; p = 0.05)) but not in women ( p = 0.55).

Statistical results were considered significant (*) or highly significant (**) at p < 0.05 and p < 0.01, respectively.

Statistical results were considered significant (*) or highly significant (**) at p < 0.05 and p < 0.01, respectively.

Although none of these comparisons reached the significance threshold after adjustment for multiple comparisons (3.69 × 10 −5 ), 179 were nominally significant ( p < 0.05) ( Supplementary Table S6a ).

In the final month, the difference in chemotherapy use is borderline significant (8.5% in males and 6.6% in females; p = 0.05). 3.4.

Moreover, we found that higher expression of SST 5 showed a trend for a lower incidence of both local and regional recurrence ( p = 0.05) ( Table 1 ).

ΔSIRI showed borderline significance ( p = 0.050).

In the Italian comparative study of standard versus more aggressive surgery [ 15 ], the addition of RT, administered preoperatively or postoperatively, seemed to result in LR reduction ( p = 0.023) and a strong trend towards increased OS ( p = 0.050).

All statistical tests were two-sided, except the Jonckheere–Terpstra test, which was prespecified as one-sided to test for an increasing trend of Mel AI noma scores with higher MOLES categories; a significance level of p < 0.05 was used.

Variables showing significant or near-significant associations ( p ≤ 0.05) were subsequently included in multivariate models to adjust for potential confounders, including adiposity indices (BMI SDS, WHR), biochemical markers of metabolic syndrome (HDL cholesterol, triglycerides, insulin), cranial radiotherapy exposure, and the number of pituitary deficiencies.

Only lymph node status had a marginally significant effect on DFS (total number of cases: 1528; Z = 1.94; p = 0.05): positive lymph node status significantly worsened the prognosis (HR > 1) by reducing DFS.

Even though these differences were not statistically significant, there was a clear trend towards a delay in the liver tumor colonization in Id1 -deficient LLC-tumor-bearing mice ( p > 0.05).

A strong trend ( p = 0.05, χ 2 = 3.7) between p62 nuclear expression and the presence of lesser B cells was also noted.

Healthy nonsmokers exhibited the highest cumulative number of unique reads among all study groups ( Figure 1 D), with a borderline significance ( p = 0.05) compared to healthy smokers.

BRAF mutation burden ( p = 0.001- post estimation by Pearson χ2 goodness-of-fit test p = 0.4) depended significantly on age at diagnosis ( p = 0.001) and in borderline significance on the anatomical site where CM developed ( p = 0.05).

Our findings showed a statistical trend toward higher levels of serum calprotectin in patients with inflammatory activity ( p < 0.05).

examined CD25 expression in 88 pediatric ALK+ ALCL patients in a univariate analysis and found that patients with high CD25 ALK+ ALCL tended to have lower 5-year overall survival (OS) compared with those with low CD25 ALK+ ALCL; however, this difference did not reach statistical significance ( p = 0.05) [ 25 ].

In univariate analysis of pediatric ALK+ ALCL patients, high CD25 expression was associated with poorer clinical outcome, but this association was of borderline significance ( p = 0.05) [ 25 ].

However, there was a clear trend towards significance between OS and MSI status in IHC (HR= 2.11 (1.00–4.45), p = 0.05).

In the multivariate analysis of this group of patients, only VEGF-C overexpression showed an independent impact on worse prognosis, with a borderline significance value ( p = 0.05, CI 95%: −0.03–3.99, HR: 7.2). 4.

A total of 1587 SNPs showed a nominally significant association with ESCC ( p < 0.05 and 95% CI did not include OR = 1).

Thus, BCRP coverage decreases in the kidneys (from 67 to 58%, p < 0.05), but increases in the liver (from 33 to 49%, p < 0.001), and in the small intestine (from 42 to 51%, on the borderline of significance) and large intestine (from 39 to 52%, p < 0.05).

In contrast, a study conducted on breast cancer reported a marginally significant reduction ( p = 0.05) in FTO gene expression in the breast tissue of patients with the AA homozygous genotype [ 54 ].

Lastly, all fixed effects that proved at least borderline significant (p ≤ 0.05) were incorporated into a final LMM for FEV 1s and VC.

According to other studies [ 36 , 37 ], our patients whose tumor occurred with obstruction or perforation showed a worse DFS compared with the other tumor manifestations, although with a trend towards significance (HR = 2.65, 95% CI 1.00–7.01, p = 0.050).