Excerpts

The 5-gene risk score calculated as PC1 was associated with the partial significance of worse prognosis (HR: 1.27, 95% CI: 1.0–1.61, p -value = 0.052), and the low-risk group was partially associated with better disease prognosis (HR: 0.72, 95% CI: 0.51–1.03, p -value = 0.073), as shown in Figure 2 A. 3.3.

After multivariate analysis, only combined nodal status and preoperative CEA ( p = 0.033), no postoperative s-CT ( p = 0.001), positive margins ( p = 0.008), and, with borderline significance, age ( p = 0.052) were independently associated with PM. 4.

A notable trend in differences in iPGV prevalence between patients identifying as Hispanic/Latinx and those identifying as Ashkenazi Jewish ( p = 0.052) was detected.

UICC-stage thereby missed statistical significance, however, a clear trend could still be observed for advanced UICC-stages (III & IV) to impair the OS of tumor patients (HR 1.486; 95% CI 0.996–2.217, p = 0.052).

Unexpectedly, although with borderline significance ( p = 0.052), there was lower FREM2 expression in LGG patients who progressed during first-line temozolomide treatment and had an IDH mutation versus patients with IDH -mutant stable/responsive disease; whereas there was no difference in IDH -WT patients ( Figure 6 ).

Compared to non-DCB patients, patients who exhibited DCB showed a trend towards increased Jaccard similarity, i.e., greater proportion of shared CDR3 sequences between PRE and FR samples ( p = 0.052; Figure S7 and Table S5 ).

The k PL showed borderline significance in predicting the variance in tumor MCT1 expression at the biopsy level ( p = 0.052; Supplementary Figure S8 ) and was independent of the cell density in tumor biopsies ( p = 0.95, Supplementary Figure S7 ).

Tumor location in the lower limb showed a trend toward longer time to diagnosis compared with abdomen/pelvis (39.4%; 95% CI −0.3% to 94.8%; p = 0.052), whereas other locations were not significantly associated with diagnostic interval.

In the T2CTC dataset ( Figure 8 ), a baseline effect of Trop2 expression was found for the bone metastatic condition ( p = 0.04255), with a marginally significant difference in slope between those with bone metastasis and without ( p = 0.052).

However, as shown in Supplementary Figure S3B , a possible trend toward significance showing an association between SETDB1 expression and NSCLC patients carrying mutations for the TP53 gene was observed (SMD: 0.15; 95% CI: −0.004–0.31; p = 0.052), with low heterogeneity ( I 2 = 0%; p = 0.60).

We found this association between the FOXL2 p.C134W mutation status and FOXL2 positivity by IHC to be marginally statistically significant (mid- p -value = 0.052).

Stage of disease had a statistically significant impact on PFS (HR:0.338; CI95%:0.161–0.709, p value = 0.004), and a borderline significant impact on OS (HR:0.474; CI95%:0.224–1.006, p value = 0.052).

DSS showed nearly significant difference ( p = 0.052): the 5-year disease-specific survival rate of SLN-negative cases was 92.7%, while that of SLN-positive cases was 77.5%.

Lymphatic invasion tended to be less frequent in the PBK -high group, but the difference was of borderline significance ( p = 0.052).

The correlation of CA125 to disease recurrence was marginally significant ( p = 0.0522) without enough statistical power to make a definitive statement about it.

Probability of OS was almost significantly higher in period V compared with period IV (1.0 vs. 0.74, p = 0.05239), and no significant differences were found in the probability of EFS and RFS between periods IV and V (0.61 ± 0.07 vs. 0.71 ± 0.1 and 0.67 ± 0.08 vs. 0.71 ± 0.12; Figure S6 ).

Moreover, for the SKOV3 cell line, CXB treatment was borderline significant compared to its control ( p -value= 0.0524) ( Figure 9 B).

Lesion Measurability and CiRT Status Lesion measurability exhibited a borderline significant association with CiRT classification ( p = 0.0525).

One study indicated that there is a borderline significant (trend p = 0.053) in the time spent watching TV to increase the risk of breast cancer in Japanese women [ 38 ].

There were no cytokines with baseline levels associated with rPFS in Cohort 2a (Cox regression p ≥ 0.05, Figure S1c, File S1 ), although IL6 almost reached statistical significance with p = 0.053 (HR = 1.16, 95% CI = 0.998–1.34). 3.4.

As the BCLC staging system is the most widely used algorithm for treatment allocation and determination of prognosis of patients with HCC [ 2 ], we also performed subgroup analyses stratified according to BCLC stage, and found a significant prognostic effect of the combined score on overall survival only in the BCLC A group, although in BCLC B and C patients, a strong trend was observed ( p = 0.053 and 0.052, respectively) ( Figure 5 c).

A marginally significant association was further observed in the validation stage with 47 cases and 48 controls using pre-diagnostic samples (OR = 1.28; 95%CI: 0.98, 2.97; p = 0.053).

Correlation between CHIP/RIPK3 Expression and Clinicopathologic Parameters Highly positive CHIP expression was significantly associated with squamous histology ( p < 0.001), histologic grade 2–3 ( p = 0.001), and stage II–III with borderline significance ( p = 0.053) ( Table 1 ).

Multivariate Analysis of Dosimetric and Non-Dosimetric Data for Acute Grade 2–3 Diarrhea The multivariate analysis ( Table 4 ) showed that V100% ( p = 0.005) and MRD ( p = 0.008) were significant factors for Grade 2–3 diarrhea, while CCRT had a statistical trend ( p = 0.053).

A similar correlation was found in the case of nuclear Gal-8, though statistically this association was of borderline significance ( p = 0.053) only ( Figure 2 and Figure 3 D).