Excerpts

The SI of T1w, T2 w, and contrast-enhanced T1w images only showed a trend toward higher values for the treatment group ( p > 0.5, p > 0.3, and p > 0.4, respectively).

Nonetheless, our analysis suggests a possible trend towards increased recurrence in Luminal B1 tumors (37.21% in the recurrence group vs. 24.71%, p = 0.51), warranting further investigation into its clinical implications [ 27 ].

While there was a numerical trend towards OS benefit with olaparib (median OS 19.3 months versus 17.1 months), this was not statistically significant (HR 0.90; 95% CI 0.66–1.23; p = 0.513) [ 6 ].

For the ROM analyses, the weighted regression test (Egger’s test) indicated mild asymmetry in the true control comparison (t(16) = −2.84, p = 0.012), while the meta-regression test did not support a significant trend ( p = 0.520) ( Supplementary Figure S1A ).

Similarly, having fewer depressed cytokines correlated with slightly improved EFS, which approached significance for osteosarcoma ( Figure 3 C: Ewing sarcoma p = 0.52; osteosarcoma p = 0.082).

As expected and in contrast to the highly significant association between the IRFMS signature and patient outcome with ER-positive breast cancers, we did not observe a significant association (Logrank p = 0.585) between our IRFMS signature and overall survival in patients with TNBC.

A slight trend was identified between the strength loss question and the ECOG stage ( p = 0.585).

Median OS was 58 months, with a slightly non-significant positive trend in OS for patients who were non-smokers and those who did not develop G3–4 AEs ( p = 0.786 and 0.799, respectively).

Unlike the findings for TGF-beta and WNT pathway alterations, the survival analysis for the EOCRC H/L patients based on RTK/RAS pathway alterations ( Figure 1 ) indicated a possible trend toward worse survival outcomes in those with RTK/RAS mutations ( p = 0.87).

Patients with intermediate BAG3 scores (score 1 and score 2) had mean disease-free survival times of 23.8 and 23.2 months, respectively—both shorter than BAG3-negative patients—implying a possible trend which needs further investigation. 4.

A nearly significant value was reported comparing the median duration of HHI treatment between locally advanced BCC patients who experienced tumor relapse (15 months [range: 7–20 months]) versus locally advanced BCC patients who did not recur (18 months [range: 1–37 months], p : 0.06).

Although its association with disease-free recurrence did not reach significance, a clear trend was observed.

Most MSI cases (91%, Table 1 ) had endometrioid histology, were early-stage I–II (86.4%, Table 1 , Figure 1 B), and showed a trend toward a high grade, significantly greater than the NSMP group (grade MSI vs.

The analysis of the Gleason score groups revealed a clear trend, wherein higher scores were significantly associated with an increased likelihood of treatment change.

Statistical analysis showed that HSV-1 serology is a highly significant independent predictor of survival [ 72 ].

These findings are highly significant, as they suggest a broader applicability of allo-HSCT to a greater number of HIV-infected patients with cancer, including lymphoma, potentially improving their clinical outcomes.

In the ITT population, the OS data also showed a trend in favor of atezolizumab but it was not statistically significant and remains immature [ 28 ].

Instead, we identified a highly significant correlation between BMD and muscle density or radiation attenuation, and as expected, a significant negative correlation with patient age.

Conclusions: Despite the rising incidence of melanoma in Hungary, the annual median Breslow thickness in our studied patient group showed a decreasing trend, accompanied by improved mortality outcomes.

identified a significant trend shift, with melanoma incidence and mortality decreasing in the past few years [ 10 ].

Although no significant association was found between TLR4 and AGER expression and lymph node involvement, we detected a marginal significance of these markers in IBC compared to non-IBC subjects.

Bowel resection (HR: 1.438, p = 0.124), stoma formation (HR: 1.739, p = 0.080), and diaphragm stripping (HR: 1.430, p = 0.150) showed a trend toward increased hazard but did not reach statistical significance.

Using the list of 392 commonly regulated genes, a total of 97 upstream regulators met statistical significance with the two most highly significant factors being beta-estradiol and ERβ ( Figure 4 L–O, Supplemental Figure S5, Supplemental Table S5 ).

In a previous study, patients affected by PC showed a trend through longer operative time and higher blood loss, even if not statistically relevant, as compared with those affected by other periampullary tumors [ 18 ].

We found an increasing trend in the incidence of early-onset ovarian cancer among NHAIAN women from 2001 to 2021, despite observing a decline in IRs among women from other race and ethnic groups.