Excerpts

Comparison of survival for patients with high levels of IGF1R versus low levels of IGF1R approached significance with a p -value of 0.0723.

We correlated the expression of CSF1R with the tumor-associated macrophage gene set and observed a highly significant positive correlation for all 37 genes ( Supplementary Table S1 ).

Patients with strong expression of CXCR-4 end VEGF receptor-3 showed a trend toward better OS when treated with FPL.

Therefore, it seems that post-RT extractions no longer involve this risk, unlike pre-RT extractions, which despite a decreasing trend, still show a certain percentage of ORN, and this has been observed in recent studies too (e.g., 7.6% in Schuurhuis, 2011 and 13% in Batstone, 2012) [ 32 , 33 ].

showed at least a weakly significant advantage of combined doxorubicin-based over doxorubicin alone chemotherapy in 5044 patients [ 47 ].

While OS showed a trend towards superiority in the higher testosterone group, the results were not statistically significant.

In contrast to previous work where UDCA treatment showed a trend toward attenuation of tissue loss in the rat Yoshida hepatoma model [ 76 ], we observed a significant drop in the tibialis weight in C26-UDCA mice.

They found that a high number of nitric oxide synthase 2 (INOS+) M1-like macrophages, both inside the tumor and at the invasive margins, was significantly associated with better OS, whereas the presence of CD163+ M2-like macrophages, inside the tumor, showed a trend toward poor prognosis [ 46 ].

Cap-chaperones, including CBC and eIF4E, are likely to be significant contributors to APA regulation as well as its dysregulation in malignancies. 2.4.

Figure 1 B illustrates other, highly significant differences in mutation frequencies between the Notch-mutated and the non-mutated subgroups.

Patient-specific models of apoptosis execution, based on the concentrations of these molecules determined in samples of stage II and III colorectal tumors, showed a trend towards impaired apoptosis execution with advanced disease stage and correlated with disease relapse after adjuvant chemotherapy.

A recent systematic review on the effect of prehabilitation on postoperative complications after hepatopancreatobiliary surgery showed a trend towards complication reduction.

However, there was a clear trend towards overexpression of TM4SF1 and IGFBP3 in patients with poor outcome.

Considering genomic disruption levels of disease-free CTCs and relapsed patients CTCs, we observed a highly significant difference between the two groups.

Since the purity corrected p -values were still highly significant for CD74, it is indicated that CD74 is marker of immune infiltration in breast cancer, but from these results, it is hard to pinpoint a certain immune cell type it is associated with.

As expected, there was a highly significant overlap between differentially expressed genes, either from CTCF overexpression ( Supplementary Figure S7A,B ) or CTCF knockdown ( Supplementary Figure S7C,D ) and genes nearby to CTCF binding motifs within accessible chromatin from untreated cells ( Supplementary Figure S7A,C ) or from cells treated with TGFβ for 10 days ( Supplementary Figure S7B,D ).

A more precise analysis of the immune cell subtype showed a trend towards increased infiltration of cytotoxic T lymphocytes and of TAMs within the EE group ( Figure 5 C).

IL-5 was significantly decreased in the tumours of the EE group compared to the SE group ( Figure 6 B), IL-4 also showed a decreasing trend ( Figure 6 D).

Engagement of OX40/CD134 on human NK cells with an agonistic MoAb augmented ADCC capacity and IFN-γ secretion and showed a trend towards greater TNFα release.

In addition, both scores in each group showed a decreasing trend over time. 3.3.

Furthermore, when involved versus extended field radiation therapy or different levels of radiation dose (<2000 cGy, 2000 to <3600 cGy, or >3600 cGy) were analyzed, there was a trend toward significance for radiation field extent.

Two independent public mRNA expression datasets from HR-positive EBC (210 patients from GSE26971 and 209 patients from GSE2034 ) showed a trend toward an association of PLK1 overexpression and a higher risk of distant recurrence ( Figure S4G ).

Due to the extremely significant diversity of all lung NET subtypes (based on clinical, histopathological or epidemiological differences), the selection of an appropriate therapeutic approach is an extremely difficult challenge for a multidisciplinary team of treating physicians including: gastroenterologist, pneumologist, endocrinologist, thoracic surgeons, pathologists, radiologists or nuclear medicine doctors, as well as oncological surgeons, clinical oncologists and radiation oncologists.

This assumption was strongly supported by clinical data from large-scale gene expression data sets (TCGA database), which revealed a highly significant correlation between FOXO3 and ITGA5 expression in ERα+, but not in ERα−, BC patients ( Figure 3 i).

Further, significant portions of TRMs expand during murine PDAC progression and exhibit a pro-fibrotic transcriptional profile and a strong trend towards poor survival when mapped to human PDAC datasets.